Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca

E, Josué R Bermeo; L, Blanca S González; G, Eva Ramón; Z, Hugo Mendieta

doi:10.4067/s0034-98872012000800009

Cited by 2 publications

(1 citation statement)

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“…Toki’s criteria are used for the diagnosis of cervical HPV, and due to the simplicity of the system, its application has been extended to the field of dentistry ( 14 ). However, the results of this study imply that its use may be inadequate in oral lesions.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Toki s criteria and determination of variables for identification of HPV L1 protein in oral lesions

Bermeo-Escalona¹,

González-López²,

Ramón-Gallegos³

et al. 2014

Med Oral

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Objectives: To evaluate the effectiveness of Toki’s criteria in identifying the HPV L1 protein in oral lesions with the use of immunohistochemistry (IHC) and to determine which criteria optimize such identification. Study Design: Retrospective study of 277 cases diagnosed as HPV lesions at 22 years. Tests of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), kappa coefficients, and chi2 values, as well as two logistic regression analyses (p≤0.05), were conducted. Results: Of the lesions studied, 96.4% (267 of 277) were positive for HPV using Toki’s criteria and 28.5% (79 of 277) were positive for L1 by IHC. Toki’s criteria showed sensitivity=93.67%, specificity=2.53%, PPV=6.99%, and NPV=46.55%. Neither concordance nor statistically significant associations were observed between both tests. The logistic regression of Toki’s criteria was useful in the diagnosis of L1, correctly classified 71.8% of the lesions positive for L1, and showed a Hosmer-Lemeshow adjustment of p=0.614 and a Nagelkerke’s coefficient of determination of 6.8%. The explanatory variables statistically significant at p≤0.05 were dyskeratosis (p=0.01) and papillomatosis (p=0.04). Forty-nine independent variables (clinical and histopathologic) were involved in the second regression analysis. The model correctly classified 85.2% of the lesions and showed a Hosmer-Lemeshow adjustment of p=0.696 and a Nagelkerke’s coefficient of determination of 60.2%. The explanatory variables statistically significant atp≤0.05 were: age younger than 35 years (p=0.001), multiple lesions (p=0.031), hyperorthokeratosis (p=0.019), focal intracellular edema (p=0.002), and the presence of 1 to more than 5 cells with degenerative changes in their nucleus (p=0.048). Conclusions: Toki’s criteria are not adequate to make a diagnosis of lesions by HPV in the mouth, but the logistic regression analysis showed clinical and histopathologic variables which optimize the identification of lesions through the L1 protein. However, a PCR study is advisable when the presence of high-risk HPV is suspected. Key words:HPV, Toki’s criteria.

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Section: Discussionmentioning

confidence: 99%

Effectiveness of Toki s criteria and determination of variables for identification of HPV L1 protein in oral lesions

Bermeo-Escalona¹,

González-López²,

Ramón-Gallegos³

et al. 2014

Med Oral

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Risk factors associated with arterial hypertension in university students in southern Sonora

FAVELA-RAMÍREZ,

BOJÓRQUEZ-DÍAZ,

CASTRO-ROBLES

et al. 2023

JNT

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The aim of this study was to identify the risk factors associated with hypertension (HT) using a logistic regression model in university students from southern Sonora. A total of 296 students took part (60.1 % female sex, 18.7 ± 0.8 years, 69.5 ± 12.5 kg) who had their blood pressure evaluated for preclinical (≥120-140/<90) and clinical (≥140/≥90) range classification and were administered the risk factor questionnaire participated. The association between explanatory factors and HT was performed by stepwise binary logistic regression. The model developed indicated that the probability of preclinical and clinical HT was 4.65 times in overweight and obese students, 7.94 times those who reported one to two histories of chronic noncommunicable diseases (NCD), 8.29 times those who indicated three to four family histories of NCD, 2.66 times those who indicated intermittent sleep, and as a protective factor a lower probability of 2.89 times those who drink coffee regularly at breakfast. It is concluded that overweight and obesity in combination with family history, poor sleep quality, and non-consumption of coffee are risk factors for HT in university students.

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Modelo de regresión logística binaria para el diagnóstico morfológico de lesiones por virus del papiloma humano (VPH) en la boca

Abstract: (Rev Med Chile 2012; 140: 1028-1034.

Cited by 2 publications

References 10 publications

Effectiveness of Toki s criteria and determination of variables for identification of HPV L1 protein in oral lesions

Effectiveness of Toki s criteria and determination of variables for identification of HPV L1 protein in oral lesions

Risk factors associated with arterial hypertension in university students in southern Sonora

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