1989
DOI: 10.1097/00004032-198901000-00008
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Epithelial Damage in Rabbit Corneas Exposed to CO2 Laser Radiation

Abstract: Corneal injury thresholds are determined for conditions not previously explored for CO2 laser radiation, including multiple-pulse exposures and a systematic investigation of the effect of beam diameter on single-pulse damage thresholds. Multiple-pulse exposures from pulse trains up to 999 pulses, having pulse repetition frequencies between 1 and 100 Hz and individual pulse durations between 10(-3) and 0.5 s, were explored. Damage thresholds are discussed in terms of an approximate critical temperature model, t… Show more

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Cited by 42 publications
(31 citation statements)
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References 7 publications
(9 reference statements)
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“…The relationship between the number of pulses delivered (N) and the per-pulse energy (EN) necessary to produce angiographically visible damage of the RPE is roughly EN/ES = N-1/4 where ES is the threshold energy for a single pulse exposure ofequal damage. This is in agreement with other studies (13,14,27).…”
Section: Dicussionsupporting
confidence: 94%
See 1 more Smart Citation
“…The relationship between the number of pulses delivered (N) and the per-pulse energy (EN) necessary to produce angiographically visible damage of the RPE is roughly EN/ES = N-1/4 where ES is the threshold energy for a single pulse exposure ofequal damage. This is in agreement with other studies (13,14,27).…”
Section: Dicussionsupporting
confidence: 94%
“…Additivity has been demonstrated for multiple 40-p,s pulses at 488 nm and 647 nm on the retina (13) and for multiple 9-ms CO2 laser pulses on the cornea (14).…”
mentioning
confidence: 94%
“…This calculation used the absorption coefficient for physiological saline (i.e., ␣ ϭ 12.0 cm Ϫ1 ) because the location of interest was just under the tear layer (which was assumed to have a thickness of 7 m) (Maher 1978). Several studies at various infrared wavelengths (10.6 m, 2.02 m, and 1.54 m) corresponding to a wide range of absorption depths (10 m to greater than 1 mm) have shown that epithelial cell injury thresholds can be correlated with a critical temperature damage model with a predicted critical temperature increase near 40°C (Bargeron et al 1989;McCally et al 1992;McCally and Bargeron 2003;McCally et al 2004). Other studies have shown that stromal cell and endothelial cell injury thresholds for CO 2 laser exposures also can be correlated with a critical temperature damage model with a similar critical temperature ( Bargeron et al 1981a;McCally et al 1983).…”
Section: Resultsmentioning
confidence: 99%
“…[2,4,[6][7][8] There are several parameters that are contributing factors to the differences in damage such as wavelength, spot size, pulse width, and intensity. [5,9] To date, there has not been an all encompassing investigation at one wavelength to determine how the variances in these parameters affects the estimated dose to 50% injury (ED 50 ) as this would be cost and time prohibitive with the current method of live animal testing. [1,10,11] Background…”
Section: Statement Of Problemmentioning
confidence: 99%