Epithelial barrier function and atopic diathesis in rosacea and perioral dermatitis

Abstract

PD is characterized by a skin barrier disorder of facial skin. It differs from rosacea in that it involves a significantly increased TEWL and features of an atopic diathesis. However, it remains disputed as to whether PD is an individual skin disease or a subtype of rosacea in atopic patients.

Granulomatous Rosacea and Periorificial Dermatitis

“…45 (Table 3) Another study compared the skin of subjects with rosacea and PD and found an association between PD and atopic dermatitis, suggesting either impaired skin barrier or incidental transfer of topical steroid to the face as the underlying pathologic condition. 61 A commonality among most of these factors is their irritant nature to the skin and alteration of microflora in the pilosebaceous unit. 5 Based on the current available evidence, the authors think that PD is induced by exogenous factors, such as atopic dermatitis or hormonal disturbance, in a susceptible host.…”

The examination of biophysical skin parameters (transepidermal water loss, skin hydration and pH value) in different body regions in Polish ponies

“…condition in human medicine. In case of human patients, they are used, among others, is assessing skin dysfunction in the course of atopic dermatitis as well as in order to determine the efficiency of locally applied treatments, including those used in atopic dermatitis (Dirschka et al 2004, Rudolph and Kownatzki 2004, Aschoff et al 2008, Grupta et al 2008, Hon et al 2011. The measurement of the aforementioned parameters, mainly transepidermal water loss, has recently also attracted the attention of veterinary dermatologists.…”

Biophysical parameters of rats’ skin after the administration of methimazole

“…An increase in TEWL was observed in humans (6,7,12) and dogs with atopic dermatitis (14,23). An open chamber and a close chamber methods can be used.…”