“…Patients with both conditions often show greater deficits in visual-spatial perception, verbal reasoning, episodic memory, motor, and reaction times than individuals with either HIV infection or alcoholism alone, and this has suggested a synergistic effect [62,[64][65][66]. Alcohol-use disorders are common in those living with HIV and in injection drug users (IDUs) and, as is well documented, heavy alcohol use has many adverse effects on people living with HIV, including increased risk of HIV transmission to others by increased risk behaviors, poor retention in care, poor adherence to treatment, impaired ability to suppress HIV, and acceleration of hepatic fibrosis, especially if there is co-infection with HCV and in the setting of prescribed ART [67][68][69][70].…”