Epileptiform state of rats and the protective effect of antiepileptic drugs: Dilantin, Depakin, and Zarontin

Abstract

The aim of the study is to investigate the direction of changes in the epileptiform state of the rat organism under the influence of antiepileptic drugs, and also to reveal the possibility of using simple criteria for the comparative assessment of the severity of their protective actions using the hardware complex «Bioscope». Materials and methods. Three series of experiments were carried out using anticonvulsants: Dilantin, Depakine, and Zarontin. In each series of experiments, the integrative state of animals was recorded in normal conditions, after administration of an anticonvulsant drug and after administration of corazole against the background of the effect of an anticonvulsant drug. For a comparative assessment of the effectiveness of the protective action of the antiepileptic drug, spectral distributions of the signals of the «Bioscope» were constructed and the power of the signals was compared in normal conditions and after administration of drugs. Results. For the relief of epileptiform states, Dilantin and Depakin are most effective - after the introduction of corazole against the background of these drugs, a higher correlation was observed between the values of the power of their spectrum compared with the norm. The injection of Dilantin has been shown to significantly change the nature of the «Bioskop» signals, while after the introduction of Depakin this does not happen. Zarontin was found to have a lower efficacy in relieving epileptiform states of the body compared to Dilantin and Depakin. Conclusion. The study revealed the feasibility of using the hardware complex «Bioscope» for the purpose of rapid assessment of the protective effect of antiepileptic drugs in epileptiform states of the body. At the same time, the possibility of using simple criteria for a comparative assessment of the severity of the protective action of drugs is shown.