Epileptic seizures induced by psychotropic drugs

Toone, Brian; Fenton, George W.

doi:10.1017/s0033291700029354

Cited by 58 publications

(22 citation statements)

References 12 publications

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“…This is in keeping with the findings of Toone & Fenton, (1977) who found a marked increase in drug prescribing in the week preceding the seizure.…”

Section: Predisposition To Mianserin-induced Convulsionssupporting

confidence: 91%

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Mianserin and convulsive seizures.

Edwards¹,

Glen-Bott²

1983

Brit J Clinical Pharma

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“…This is in keeping with the findings of Toone & Fenton, (1977) who found a marked increase in drug prescribing in the week preceding the seizure.…”

Section: Predisposition To Mianserin-induced Convulsionssupporting

confidence: 91%

“…They adopt two different approaches. The first was based on the 10 patients who had convulsions during treatment with amitriptyline and the seven who had seizures during treatment with imipramine reported by Toone & Fenton (1977). These were inpatients at the Maudsley and Bethlem Royal Hospitals during the seven year period 1967-73.…”

Section: Investigationsmentioning

confidence: 99%

Mianserin and convulsive seizures.

Edwards¹,

Glen-Bott²

1983

Brit J Clinical Pharma

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“…However, convul sions also occur at therapeutic doses, especially in pa tients with already decreased seizure thresholds [Toone and Fenton, 1977]. A variety of animal models have been developed to determine the (pro)convulsive potency of drugs by determining their effects on: -thalamic discharges in rats and cats [Ito et al, 1977]; -photically evoked afterdischarges in hooded rats [Big ler.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the (Pro)convulsive Properties of Fluvoxamine and Clovoxamine with Eight Other Antidepressants in an Animal Model

1984

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Freely moving rats were implanted with cortical, caudal, thalamic, and reticular electrodes. Drugs were infused intravenously at a constant rate up to a final cumulative dose of 40, 50, or 60 mg/kg. Doses of 10 mg/kg imipramine, viloxazine, desmethylimipramine, mianserin, and maprotiline produced spike-wave complexes, spikes, and increased spindling. General sustained discharges occurred after 20 mg/kg of mianserin, viloxazine, imipramine, desmethylimipramine and amitriptyline, and after 30 mg/kg of maprotiline. An abnormal high-amplitude pattern was evident after mianserin, amitriptyline, imipramine, and desmethylimipramine. On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg). Ranking the tested antidepressants in decreasing order in accordance with their relative (pro)convulsive properties gives:amitriptyline > mianserin >> imipramine > desmethylimipramine > viloxazine >> maprotiline >> zimelidine > clovoxamine > nomifensine = fluvoxamine.

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“…4) All the investigated neuroleptics prolonged the dura tion of the EEG paroxysms. The ED300 was calculated in order to see whether it correlates to some extent with the clinically critical dose for an eventual seizure attack in susceptible patients [14,40], Thioridazine and chlor promazine prolonged the EEG paroxysms with ED300 of 27 and 15 mg/kg p.o., respectively. Haloperidol -with an ED300 of 2 mg/kg p.o.…”

Section: Resultsmentioning

confidence: 99%

Spontaneous EEG Paroxysms in the Rat: Effects of Psychotropic and Alpha-Adrenergic Agents

Kleinlogel¹

1985

Neuropsychobiology

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Approximately 20% of Charles River rats which were chronically implanted with brain electrodes for EEG recordings exhibited within half a year of the implantation spontaneous, paroxysmally occurring, steep EEG potentials of high amplitude (spikes and waves) whilst falling asleep. These EEG paroxysms were dose dependently antagonized by the ‘petit mal drugs dipropylacetate, ethosuximide and trimethadione as well as by the anticonvulsant drugs diazepam and nitrazepam. The neuroleptics chlorpromazine, haloperidol and thioridazine prolonged the EEG paroxysms. The α₁-adrenoceptor antagonist prazosin and the α₂-adrenoceptor agonists guanfacine and clonidine prolonged, whereas the α₂-adrenoceptor antagonist yohimbine shortened, the EEG paroxysms. The effect of guanfacine was antagonized by yohimbine. The convulsant drugs bicuculhne, 3-mercaptopropionic acid and pentetrazol had only a slight influence on the EEG paroxysms. The results are discussed with respect to the anti- and proconvulsant and convulsant activity of psychotropic drugs and their underlying mechanisms of action, particularly with regard to their interaction with central α-adrenergic mechanisms.

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Epileptic seizures induced by psychotropic drugs

Cited by 58 publications

References 12 publications

Mianserin and convulsive seizures.

Mianserin and convulsive seizures.

Comparison of the (Pro)convulsive Properties of Fluvoxamine and Clovoxamine with Eight Other Antidepressants in an Animal Model

Spontaneous EEG Paroxysms in the Rat: Effects of Psychotropic and Alpha-Adrenergic Agents

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