No abstract

female brown mice and male albino rats, audiogenic seizures using "Friedland" chimes and a three inch doorbell in genetically susceptible mice of both sexes, and photically induced seizures in adolescent Senegalese baboons of the species, Papio papio.' 2 9 Detailed recordings of the electrocorticogram in the cat encephale isok preparation after acute intravenous or chronic oral administration of viloxazine failed to reveal any overt epileptogenic activity.' "1 In rabbits showing spontaneous electroencephalographic epileptiform discharges viloxazine given intravenously caused the disappearance of paroxysmal features which become replaced by synchronous low frequency activity.'2 The recent work on viloxazine has shown that, in contrast to several other antidepressants, it has little effect on spike activity in perfused guinea pig hypocampal slices.'3 In contrast to these observations at low/therapeutic dose levels, abnormally high blood levels may be associated with a proconvulsant action.9In clinical trials of viloxazine in which epileptic patients were included (

Four cases of convulsive seizures occurring during treatment with nomifensine have been notified to the Committee on the Safety of Medicines of the United Kingdom, and 22 cases have been reported from other countries. The occurrence of convulsions is not in keeping with the results of animal experiments, studies of epileptic patients treated with nomifensine or observations made following overdoses of this drug. Nomifensine may thus not be entirely free from epileptogenic properties as previously presumed.