Epileptic seizures in subcortical vascular encephalopathy

Schreiner, A.; Pohlmann‐Eden, Bernd; Schwartz, Armin; Hennerici, Michael G.

doi:10.1016/0022-510x(95)00020-3

Cited by 32 publications

(26 citation statements)

References 22 publications

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“…In a previous study [26], the incidence of epileptic seizures in subcortical vascular encephalopathy was more related to a higher rate of lacunae within the subcortical white matter rather than in the basal ganglia and brain stem. The higher incidence of epilepsy in this group was explained by diaschisis resulting in suppression of the inhibitory cortical activity.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and Outcomes of Patients with Seizures according to the Time of Onset in Relation to Stroke

Reuck

Sieben²,

Maele³

2008

Eur Neurol

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Background/Aim: Although most late-onset seizures (LS) appear within 2 years after stroke, some of them occur later and their characteristics are unknown. The aim of this study was to compare the characteristics of patients with very-late-onset seizures (VLS) to those with early-onset seizures (ES) and those with LS. Patients: The study group consisted of 204 patients with stroke-related seizures (29 ES, 128 LS and 47 VLS). Results: Intracranial haemorrhage was a more frequent cause of ES than of LS and no cause at all of VLS. On the other hand, 25% of the VLS were related to lacunar strokes. Status epilepticus occurred in 20.7% of the ES, in 11.7% of the LS and in 2.1% of the VLS patients. Seizure recurrences were 13.8% in the ES, 54.7% in the LS and 34.0% in the VLS group. Neurological impairment, at stroke onset, and the degree of disability were more severe in patients with ES compared to those with LS and were very mild in the VLS group. The EEG findings as a whole did not show significant differences between the three groups, although a normal EEG was more frequent in the VLS group. Conclusion: VLS occur in patients with minor ischaemic strokes with good recovery and benign disease course.

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Section: Discussionmentioning

confidence: 99%

Characteristics and Outcomes of Patients with Seizures according to the Time of Onset in Relation to Stroke

Reuck

Sieben²,

Maele³

2008

Eur Neurol

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“…Blood cells from 21 patients (12 men and 9 women) with subcortical vascular encephalopathy (SVE) [13,[18][19][20] following the diagnostic criteria for research studies (NINDS-AIREN) [21] were used as a second group of demented patients, to elucidate differences in pathogenesis. Patients underwent a structured medical and neurological examination as well as neuropsychological interviews following a research protocol with particular emphasis on the presence of motor and gait disturbances, urinary incontinence, memory and attention disorders, frontal release signs, and aspontaneous episodes.…”

Section: Subjectsmentioning

confidence: 99%

Elevated Levels of Fragmented DNA Nucleosomes in Native and Activated Lymphocytes Indicate an Enhanced Sensitivity to Apoptosis in Sporadic Alzheimer’s Disease

Eckert¹,

Oster²,

Zerfass³

et al. 2001

Dement Geriatr Cogn Disord

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Apoptotic cell death is thought to be the most likely mechanism of cell death contributing to neurodegeneration in Alzheimer’s disease (AD). Here, we provide evidence that in sporadic AD cases the vulnerability of peripheral cells to undergo apoptosis is increased compared to non-demented elderly controls and, very importantly, to patients with subcortical vascular encephalopathy (SVE) as another, but demented control group. Quiescent ‘native’ and ‘activated’ lymphocytes from AD patients that were predisposed to commit apoptotic cell death by priming the cells with interleukin-2, are shown to accumulate apoptosing cells to a significantly higher extent in spontaneous and in oxidative stress-induced in vitro apoptosis. Our results demonstrate robust differences in cell death sensitivity between AD and vascular dementia. In none of the conditions investigated, lymphocytes from SVE patients were significantly different from non-demented controls. The comparable findings of a higher extent of apoptotic features in neurons and in peripheral blood cells of AD patients are remarkable and may suggest a rather general modulation of apoptotic mechanisms by the disease, which even can be picked up at the level of peripheral lymphocytes under specific in vitro conditions.

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“…Some case series and stroke registries have already described the infrequent occurrence of epileptic seizures in subcortical ischaemia [4, 5, 6, 9, 10]. However, the predictive factors for this occurrence are unknown.…”

Section: Introductionmentioning

confidence: 99%

Epileptic Seizures following Subcortical Infarcts

Bentes

Pimentel

Ferro³

2001

Cerebrovasc Dis

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Stroke is one of the most frequent causes of seizures in adulthood. Subcortical infarcts have been associated with post-stroke epileptic seizures, although less frequently than cortical ischaemia. We studied 113 patients from a hospital stroke registry. The patients had subcortical non-lacunar infarcts (64 striatocapsular infarcts, 13 thalamic, 8 choroidal artery territory, 28 internal border zone and white matter medullary infarcts) and at least 1 year of follow-up. Only 4 patients (3.5%) with striatocapsular infarcts suffered an epileptic seizure. Two seizures occurred within the first 24 h, 1 within the first month and 1 within the first year of stroke onset. Emboligenic cardiac conditions were significantly more common in patients with seizures (difference 37%; 95% confidence intervals 2–72%). Subsequently to subcortical infarct, epileptic seizures are infrequent, tend to occur early after stroke and have a very low 1-year recurrence risk.

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Epileptic seizures in subcortical vascular encephalopathy

Cited by 32 publications

References 22 publications

Characteristics and Outcomes of Patients with Seizures according to the Time of Onset in Relation to Stroke

Characteristics and Outcomes of Patients with Seizures according to the Time of Onset in Relation to Stroke

Elevated Levels of Fragmented DNA Nucleosomes in Native and Activated Lymphocytes Indicate an Enhanced Sensitivity to Apoptosis in Sporadic Alzheimer’s Disease

Epileptic Seizures following Subcortical Infarcts

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