Epileptic seizures and survival in early disease of grade 2 gliomas

Danfors, Torsten; Ribom, Dan; Berntsson, Shala Ghaderi; Smits, Anja

doi:10.1111/j.1468-1331.2009.02599.x

Cited by 48 publications

(41 citation statements)

References 27 publications

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“…In line with this consideration, oligodendroglioma carry a higher risk of epilepsy than astrocytoma, thus suggesting that functional rearrangement involving synaptic plasticity should be required in peritumoral tissue epileptogenicity (Schaller and Ruegg 2003). In a retrospective chart review, 81% of patients with G2G presented with at least one seizure (Chang, Potts et al 2008), while in another study 88 among 101 patients with G2G had seizure at disease onset (Danfors, Ribom et al 2009). In approximatively half of the patients with G2G and seizures, epilepsy appeared to be drug resistant (Chang, Potts et al 2008) (Danfors, Ribom et al 2009).…”

Section: -1 Grade II Glioma Epilepsymentioning

confidence: 94%

Brain tumor epilepsy: A reappraisal and six remaining issues to be debated

Vercueil

2011

Revue Neurologique

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Epilepsy associated with brain tumors presents with specific features deserving medical attention : 1) although commonly reported in patients with brain tumor, either as revealing mode or as a remote complication, limited knowledge is available regarding their epidemiology, clinical evolution, surgical outcome, physiopathology and treatment, providing only clues for clinical management. 2) seizures appear even more threatening for patients and care-givers, providing seizures could meant tumor progression and recurrence. This factor adds to the negative impact epilepsy carry on quality of life measures. 3) pharmacotherapy is complicated by the use of chemotherapy and interaction between antiepileptic drugs and antineoplastic agents are frequent and potentially harmful. 4) the high incidence of epilepsy enlights the question of prophylaxy with antiepileptic drugs, in patients without seizures, or during the perioperative period, and after surgery, when gross total resection has been achieved. This article attempts to provide the reader with an overview of brain tumor epilepsy in its specific aspects and to comment on some remaining issues.

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Section: -1 Grade II Glioma Epilepsymentioning

confidence: 94%

Brain tumor epilepsy: A reappraisal and six remaining issues to be debated

Vercueil

2011

Revue Neurologique

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“…High-grade glioma patients with seizures experienced significantly longer overall survival compared to those without seizures across both univariate and multivariate analyses, but this trend was not observed in individuals with low-grade glioma. However, several other groups have also found a positive association between seizure history and overall survival in low-grade glioma patients (Bartolomei et al, 1997;Stupp et al, 2003;Blumcke et al, 2004;Krzyszkowski et al, 2004;Danfors et al, 2009). …”

Section: Seizures As a Prognostic Indicator In Gliomasmentioning

confidence: 97%

“…However, some have noted that peripherally located or slower-growing tumors that are more likely to be associated with epilepsy are also easier to treat, accounting for the association (Danfors et al, 2009). Others have proposed that gliomas causing seizures may represent a unique histopathologic tumor subtype (Bartolomei et al, 1997;Blumcke et al, 2004).…”

Section: Seizures As a Prognostic Indicator In Gliomasmentioning

confidence: 99%

“…Others have proposed that gliomas causing seizures may represent a unique histopathologic tumor subtype (Bartolomei et al, 1997;Blumcke et al, 2004). Furthermore, while seizures at the time of glioma diagnosis are associated with a survival advantage, seizure recurrence after treatment portends a poor prognosis, possibly due to the association between tumor regrowth and recurrent epilepsy Danfors et al, 2009). In low-grade gliomas, relapse of seizures after a period of 6 months or more of seizure freedom is an indicator of tumor progression in about 50% of patients (Chang et al, 2008b;You et al, 2012).…”

Section: Seizures As a Prognostic Indicator In Gliomasmentioning

confidence: 99%

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Epilepsy and Brain Tumors

Newton

Maschio²,

Pritikin³

2015

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Seizures are common in patients with brain tumors, and epilepsy can significantly impact patient quality of life. Therefore, a thorough understanding of rates and predictors of seizures, and the likelihood of seizure freedom after resection, is critical in the treatment of brain tumors. Among all tumor types, seizures are most common with glioneuronal tumors (70-80%), particularly in patients with frontotemporal or insular lesions. Seizures are also common in individuals with glioma, with the highest rates of epilepsy (60-75%) observed in patients with low-grade gliomas located in superficial cortical or insular regions. Approximately 20-50% of patients with meningioma and 20-35% of those with brain metastases also suffer from seizures. After tumor resection, approximately 60-90% are rendered seizure-free, with most favorable seizure outcomes seen in individuals with glioneuronal tumors. Gross total resection, earlier surgical therapy, and a lack of generalized seizures are common predictors of a favorable seizure outcome. With regard to anticonvulsant medication selection, evidence-based guidelines for the treatment of focal epilepsy should be followed, and individual patient factors should also be considered, including patient age, sex, organ dysfunction, comorbidity, or cotherapy. As concomitant chemotherapy commonly forms an essential part of glioma treatment, enzyme-inducing anticonvulsants should be avoided when possible. Seizure freedom is the ultimate goal in the treatment of brain tumor patients with epilepsy, given the adverse effects of seizures on quality of life.

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“…Approximately 40%-90% of patients with LGG have epilepsy. 4,13,27 Thus, they often require prophylactic anticonvulsant medication. Anticonvulsants are known for their teratogenic effects and could be a major impediment for pregnancy, causing possible birth defects.…”

Section: Discussionmentioning

confidence: 99%

The effect of pregnancy on survival in a low-grade glioma cohort

Rønning

Helseth

Meling

et al. 2016

JNS

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A dult low-grade gliomas (LGGs; World Health Organization [WHO] Grade II) are progressive brain tumors with diffuse borders against normal brain tissue and have a propensity to spread in an infiltrative manner throughout the brain. 16 These tumors demonstrate a tendency to evolve into more aggressive highgrade gliomas (HGGs). WHO Grade I tumors are also usually termed "LGG." However, the nature of these lesions is quite different from their Grade II counterpart in that the Grade I tumor is not infiltrative and usually demonstrates more compact growth characteristics, making it more amenable to complete resection.LGGs compose approximately 15% of all gliomas. 26 Patients most often present with seizures, but they can also demonstrate neurological and cognitive deficits or complain of headache.2,26 There is a clear tendency for patients with these tumors to present earlier in life than those with higher-grade tumors, with the median age at diagnosis being between 40 and 50 years. 11Therefore, female patients are often diagnosed with LGG while within their reproductive years. As clinicians, we are often questioned and expected to counsel female patients on the issue of how pregnancy and delivery affects the biology of their LGG and, ultimately, their own survival. To our knowledge, only 2 other reports detail the effects of pregnancy on patients with LGG. These reports originate from the French glioma study group and feature information on the clinical symptoms and speed of tumor growth in 11 patients and 12 pregnancies.19, 21 The results indicate that there is a peri-gestational increase in lesion growth rates witnessed on MR images. However, is it still unknown how this affects outcome and survival.Since patients often present with seizures, they are

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Epileptic seizures and survival in early disease of grade 2 gliomas

Abstract: The presence and termination of early seizure manifestations may be favourable prognostic factors in patients with low-grade gliomas.

Cited by 48 publications

References 27 publications

Brain tumor epilepsy: A reappraisal and six remaining issues to be debated

Brain tumor epilepsy: A reappraisal and six remaining issues to be debated

Epilepsy and Brain Tumors

The effect of pregnancy on survival in a low-grade glioma cohort

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