Epilepsy and cognition

Kesselmayer, Rachel Friefeld; Morel, Gloria M.; Bordenave, Jessica M.; Jones, Jana E.; Hermann, Bruce P.

doi:10.1016/b978-0-12-814877-8.00013-1

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…Several lines of investigation have earlier reported that epileptic zebrafish exhibited memory impairment ( Kundap et al, 2017 ; Kundap et al, 2019a ) which is in agreement with the fact that memory impairment is associated with epilepsy ( Kesselmayer et al, 2019 ; Laurent et al, 2020 ). This reflects that the future therapeutic strategies against epileptic seizures should not only exert the disease supression but also ameliorate the related memory impairment.…”

Section: Discussionsupporting

confidence: 82%

Anti-High Mobility Group Box-1 Monoclonal Antibody Attenuates Seizure-Induced Cognitive Decline by Suppressing Neuroinflammation in an Adult Zebrafish Model

2021

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Epilepsy is a chronic brain disease afflicting around 70 million global population and is characterized by persisting predisposition to generate epileptic seizures. The precise understanding of the etiopathology of seizure generation is still elusive, however, brain inflammation is considered as a major contributor to epileptogenesis. HMGB1 protein being an initiator and crucial contributor of inflammation is known to contribute significantly to seizure generation via activating its principal receptors namely RAGE and TLR4 reflecting a potential therapeutic target. Herein, we evaluated an anti-seizure and memory ameliorating potential of an anti-HMGB1 monoclonal antibody (mAb) (1, 2.5 and 5 mg/kg, I.P.) in a second hit Pentylenetetrazol (PTZ) (80 mg/kg, I.P.) induced seizure model earlier stimulated with Pilocarpine (400 mg/kg, I.P.) in adult zebrafish. Pre-treatment with anti-HMGB1 mAb dose-dependently lowered the second hit PTZ-induced seizure but does not alter the disease progression. Moreover, anti-HMGB1 mAb also attenuated the second hit Pentylenetetrazol induced memory impairment in adult zebrafish as evidenced by an increased inflection ration at 3 and 24 h trail in T-maze test. Besides, decreased level of GABA and an upregulated Glutamate level was observed in the second hit PTZ induced group, which was modulated by pre-treatment with anti-HMGB1 mAb. Inflammatory responses occurred during the progression of seizures as evidenced by upregulated mRNA expression of HMGB1, TLR4, NF-κB, and TNF-α, in a second hit PTZ group, which was in-turn downregulated upon pre-treatment with anti-HMGB1 mAb reflecting its anti-inflammatory potential. Anti-HMGB1 mAb modulates second hit PTZ induced changes in mRNA expression of CREB-1 and NPY. Our findings indicates anti-HMGB1 mAb attenuates second hit PTZ-induced seizures, ameliorates related memory impairment, and downregulates the seizure induced upregulation of inflammatory markers to possibly protect the zebrafish from the incidence of further seizures through via modulation of neuroinflammatory pathway.

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Section: Discussionsupporting

confidence: 82%

Anti-High Mobility Group Box-1 Monoclonal Antibody Attenuates Seizure-Induced Cognitive Decline by Suppressing Neuroinflammation in an Adult Zebrafish Model

2021

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“…acidentes vasculares e doenças degenerativas (KESSELMAYER, et al, 2019). A cirurgia de epilepsia é um tratamento eletivo e o declínio cognitivo é a morbidade mais comum associada ao procedimento.…”

Section: Introductionunclassified

Caracterização De Amostra E Perfil Neuropsicológico De Pacientes Com Epilepsia Fármaco-Resistente

Aleixo¹,

Fiorotto²,

Borges³

2020

A Psicologia Com Foco Nas Múltiplas Práticas Em Saúde Mental

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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“…Thus, the impact of epilepsy is not only determined by the clinical aspects of the disease such as frequency and severity of seizures, psychological and social factors also cause great damage to the patient's life.Estima-se que existam 50 milhões de pessoas no mundo com epilepsia.Para mais de 30% desses pacientes, a condição é classificada como refratária, com convulsões não controladas, contínuas apesar da administração de drogas antiepilépticas(ELVERMAN et al, 2019). infecções do SNC, trauma cranioencefálico, neoplasias do SNC, acidentes vasculares e doenças degenerativas(KESSELMAYER, et al, 2019).O diagnóstico de epilepsia, na maioria das vezes é possível realizar clinicamente, através da obtenção da história detalhada do paciente e do exame físico, com forte ênfase nas áreas neurológicas e psiquiátricas. A idade de início, frequência, duração, bem como a existência de aura, sensação que precede a crise e dos possíveis desencadeantes são informações importantes.…”

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Relato De Experiência Em Estágio Obrigatório No Curso De Psicologia Em Um Projeto Institucional De Inclusão Da Pessoa Idosa

Melo¹,

Carvalho²,

Araújo³

et al. 2020

A Psicologia Com Foco Nas Múltiplas Práticas Em Saúde Mental

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Epilepsy and cognition

Cited by 5 publications

References 47 publications

Anti-High Mobility Group Box-1 Monoclonal Antibody Attenuates Seizure-Induced Cognitive Decline by Suppressing Neuroinflammation in an Adult Zebrafish Model

Anti-High Mobility Group Box-1 Monoclonal Antibody Attenuates Seizure-Induced Cognitive Decline by Suppressing Neuroinflammation in an Adult Zebrafish Model

Caracterização De Amostra E Perfil Neuropsicológico De Pacientes Com Epilepsia Fármaco-Resistente

Relato De Experiência Em Estágio Obrigatório No Curso De Psicologia Em Um Projeto Institucional De Inclusão Da Pessoa Idosa

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