2018
DOI: 10.1371/journal.pone.0196667
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Epiisopilosine alkaloid has activity against Schistosoma mansoni in mice without acute toxicity

Abstract: Schistosomiasis is a disease caused by parasites of the genus Schistosoma, currently affecting more than 200 million people. Among the various species of this parasite that infect humans, S. mansoni is the most common. Pharmacological treatment is limited to the use of a single drug, praziquantel (PZQ), despite reports of parasite resistance and low efficacy. It is therefore necessary to investigate new potential schistosomicidal compounds. In this study, we tested the efficacy of epiisopilosine (EPIIS) in a m… Show more

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Cited by 37 publications
(27 citation statements)
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“…This finding could be attributed to a high reduction in the worm burden as a result of treatment with spironolactone and/or inhibition of oviposition by adult helminths. A significant reduction in eggs collected from the intestine (oogram) or feces has been described with other antischistosomal compounds (21)(22)(23). In addition, the pathology normally associated with the deposition of schistosome eggs in the spleen and liver was clearly ameliorated, mainly when spironolactone was administered for 5 days.…”
Section: Discussionmentioning
confidence: 93%
See 1 more Smart Citation
“…This finding could be attributed to a high reduction in the worm burden as a result of treatment with spironolactone and/or inhibition of oviposition by adult helminths. A significant reduction in eggs collected from the intestine (oogram) or feces has been described with other antischistosomal compounds (21)(22)(23). In addition, the pathology normally associated with the deposition of schistosome eggs in the spleen and liver was clearly ameliorated, mainly when spironolactone was administered for 5 days.…”
Section: Discussionmentioning
confidence: 93%
“…For scanning electron microscopy, control and treated adult parasites were fixed for at least 3 h in 2.5% glutaraldehyde (Sigma) at room temperature. Experimental protocols for scanning electron microscopy were published previously (22,23). Samples were metalized with gold using a Desk II sputter coater (Denton Vacuum LLC, Moorestown, NJ) and then observed using a JEOL SM-6460LV high-resolution scanning electron microscopy (JEOL, Ltd., Tokyo, Japan).…”
Section: Methodsmentioning
confidence: 99%
“…A study conducted by Guimarães et al (2018) demonstrated the efficacy of epiisopilosine (EPIIS) in a murine model of schistosomiasis. A single dose of EPIIS (100 or 400 mg/kg) administered orally to mice infected with adult S. mansoni resulted in reduced worm burden and egg production.…”
Section: Discussionmentioning
confidence: 99%
“…Schistosoma ' tegument of is well-recognized as an important drug target and model of study in schistosomiasis [ 41 ]. In this regard, tegument is pivotal for the survival of Schistosoma not only because it is one of the major route for nutrient absorption, but also because it is important for the protection of schistosomes, since tegumental changes might result in exposure of parasite antigens to the host immune system [ 41 , 42 ].…”
Section: Resultsmentioning
confidence: 99%