Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

Broholm, Christa; Ribel‐Madsen, Rasmus; Hjort, Line; Olsson, Anna; Ahlers, J; Hansen, Ninna S.; Schrölkamp, Maren; Gillberg, Linn; Perfilyev, Alexander; Volkov, Petr; Ling, Charlotte; Jørgensen, Steffen; Mortensen, Bent Ole Gram; Hingst, Janne R.; Wojtaszewski, Jørgen F. P.; Schéele, Camilla; Brøns, Charlotte; Pedersen, Bente Klarlund; Vaag, Allan

doi:10.1080/07435800.2019.1669160

Cited by 9 publications

(6 citation statements)

References 44 publications

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“…The role of HDAC7 in controlling the stemness of both normal and cancer cells has been reported by different studies [7][8][9]36,37]. By contrast, the mechanisms and genes that are supervised by HDAC7 for the regulation of stemness features are less defined.…”

Section: Discussionmentioning

confidence: 99%

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A Regulative Epigenetic Circuit Supervised by HDAC7 Represses IGFBP6 and IGFBP7 Expression to Sustain Mammary Stemness

et al. 2021

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Background: In the breast, the pleiotropic epigenetic regulator HDAC7 can influence stemness. Materials & Methods: The authors used MCF10 cells knocked-out for HDAC7 to explore the contribution of HDAC7 to IGF1 signaling. Results: HDAC7 buffers H3K27ac levels at the IGFBP6 and IGFBP7 genomic loci and influences their expression. In this manner, HDAC7 can tune IGF1 signaling to sustain stemness. In HDAC7 knocked-out cells, RXRA promotes the upregulation of IGFBP6/7 mRNAs. By contrast, HDAC7 increases FABP5 expression, possibly through repression of miR-218. High levels of FABP5 can reduce the delivery of all-trans-retinoic acid to RXRA. Accordingly, the silencing of FABP5 increases IGFBP6 and IGFBP7 expression and reduces mammosphere generation. Conclusion: The authors propose that HDAC7 controls the uptake of all-trans-retinoic acid, thus influencing RXRA activity and IGF1 signaling.

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Section: Discussionmentioning

confidence: 99%

“…HDAC7 can also regulate stem cell functions, particularly in the breast. Its actions are mediated at the level of both the microenvironment and intrinsic stemness program regulation [7][8][9][10]. Several secreted factors that create and sculpt the microenvironment are under the repressive action of HDAC7 [9].…”

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confidence: 99%

A Regulative Epigenetic Circuit Supervised by HDAC7 Represses IGFBP6 and IGFBP7 Expression to Sustain Mammary Stemness

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Article A Genome-Wide Association Study To Identify Candidate Genes for Metabolic Disorders in Offspring by In Vitro Fertilization

2021

Preprint

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Background In vitro fertilization (IVF) processes increase offspring's short-term and long-term health risks, but their mechanisms remain unclear. Methods We conducted a bibliometric analysis to determine the landscape of IVF offspring health. Subsequently, a bioinformatics method was utilized to identify the co-genes properties and biological function mechanisms of IVF and type 2 diabetes mellitus (T2DM). Finally, we predicted compounds against key targets and performed multiple validations of the mechanisms underlying IVF offspring health risks. Results We identified 15 genes associated with T2DM, and their biological functions are primarily associated with lipid metabolism. We also identified the properties of co-genes, modified characteristics, confirmed a conserved motif, identified 3 SNPs sites, and determined the three core genes, APOA1, APOB, and APOE, which were mainly correlated with metabolic and cardiovascular diseases. In addition, we predicted drugs that may improve metabolic abnormalities in IVF offspring. Conclusion The impact of aberrant lipid metabolism in offspring after IVF therapy warrants additional investigation, particularly in terms of long-term health consequences and possible mechanisms.

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“…However, it is an indisputable fact that adverse intrauterine environments affect children's health, including metabolic diseases [43] . As a common cause of fetal growth restriction(FGR), LBW is a major public health problem having a higher risk of developing adipose tissue metabolic abnormalities, insulin resistance, and T2MD in adults compared to normal birth weight [44] . Fatty acid metabolism is closely related to adult metabolic diseases; abnormal fatty acid metabolism leads to lipid deposition, obesity, hepatic insulin resistance, and glucose overproduction [ 45 ] .…”

Section: Discussionmentioning

confidence: 99%

A Genome-Wide Association Study To Identify Candidate Genes for Metabolic Disorders in Offspring by In Vitro Fertilization

2021

Preprint

View full text Add to dashboard Cite

In vitro fertilization (IVF) processes increase offspring's short-term and long-term health risks, but their mechanisms remain unclear. We conducted a bibliometric analysis to determine the landscape of IVF offspring health. Subsequently, a bioinformatics method was utilized to identify the co-genes properties and biological function mechanisms of IVF and type 2 diabetes mellitus (T2DM). Finally, we predicted compounds against key targets and performed multiple validations of the mechanisms underlying IVF offspring health risks. We identified 15 genes associated with T2DM, and their biological functions are primarily associated with lipid metabolism. We also identified the properties of co-genes, modified characteristics, confirmed a conserved motif, identified 3 SNPs sites, and determined the three core genes, APOA1, APOB, and APOE, which were mainly correlated with metabolic and cardiovascular diseases. In addition, we predicted drugs that may improve metabolic abnormalities in IVF offspring. The impact of aberrant lipid metabolism in offspring after IVF therapy warrants additional investigation, particularly in terms of long-term health consequences and possible mechanisms.

show abstract

Epigenome- and Transcriptome-wide Changes in Muscle Stem Cells from Low Birth Weight Men

Cited by 9 publications

References 44 publications

A Regulative Epigenetic Circuit Supervised by HDAC7 Represses IGFBP6 and IGFBP7 Expression to Sustain Mammary Stemness

A Regulative Epigenetic Circuit Supervised by HDAC7 Represses IGFBP6 and IGFBP7 Expression to Sustain Mammary Stemness

Article A Genome-Wide Association Study To Identify Candidate Genes for Metabolic Disorders in Offspring by In Vitro Fertilization

A Genome-Wide Association Study To Identify Candidate Genes for Metabolic Disorders in Offspring by In Vitro Fertilization

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