Epigenetics of Alzheimer’s Disease

Perković, Matea Nikolac; Paska, Alja Videtič; Konjevod, Marcela; Kouter, Katarina; Štrac, Dubravka Švob; Erjavec, Gordana Nedić; Pivac, Nela

doi:10.3390/biom11020195

Cited by 82 publications

(92 citation statements)

References 283 publications

(179 reference statements)

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“…Furthermore, from the direct impact of Aβ on mitochondria, some authors also demonstrated that mitochondrial DNA is altered in elderly and AD patients [ 57 ]. Various factors can influence mitochondrial activity, contributing to AD progression.…”

Section: Aβ Vs Oxidative Stressmentioning

confidence: 99%

Oxidative Stress and Beta Amyloid in Alzheimer’s Disease. Which Comes First: The Chicken or the Egg?

et al. 2021

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The pathogenesis of Alzheimer’s disease involves β amyloid (Aβ) accumulation known to induce synaptic dysfunction and neurodegeneration. The brain’s vulnerability to oxidative stress (OS) is considered a crucial detrimental factor in Alzheimer’s disease. OS and Aβ are linked to each other because Aβ induces OS, and OS increases the Aβ deposition. Thus, the answer to the question “which comes first: the chicken or the egg?” remains extremely difficult. In any case, the evidence for the primary occurrence of oxidative stress in AD is attractive. Thus, evidence indicates that a long period of gradual oxidative damage accumulation precedes and results in the appearance of clinical and pathological AD symptoms, including Aβ deposition, neurofibrillary tangle formation, metabolic dysfunction, and cognitive decline. Moreover, oxidative stress plays a crucial role in the pathogenesis of many risk factors for AD. Alzheimer’s disease begins many years before its symptoms, and antioxidant treatment can be an important therapeutic target for attacking the disease.

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Section: Aβ Vs Oxidative Stressmentioning

confidence: 99%

Oxidative Stress and Beta Amyloid in Alzheimer’s Disease. Which Comes First: The Chicken or the Egg?

et al. 2021

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“…Although the emergence of Omics technologies has allowed to better characterize epigenetic modifications in the context of AD, these studies, that have been the subject of recent reviews ( Monti et al, 2020 ; Coppedè, 2021 ; Nikolac Perkovic et al, 2021 ), are outside the scope of the present manuscript which is focused on the putative influence of the early environment on AD programming.…”

Section: Epigenetic Mechanisms Mediate Long-term Influence Of Environ...mentioning

confidence: 99%

Early-Life Environment Influence on Late-Onset Alzheimer’s Disease

Gauvrit

Benderradji

Buée

et al. 2022

Front. Cell Dev. Biol.

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With the expand of the population’s average age, the incidence of neurodegenerative disorders has dramatically increased over the last decades. Alzheimer disease (AD) which is the most prevalent neurodegenerative disease is mostly sporadic and primarily characterized by cognitive deficits and neuropathological lesions such as amyloid -β (Aβ) plaques and neurofibrillary tangles composed of hyper- and/or abnormally phosphorylated Tau protein. AD is considered a complex disease that arises from the interaction between environmental and genetic factors, modulated by epigenetic mechanisms. Besides the well-described cognitive decline, AD patients also exhibit metabolic impairments. Metabolic and cognitive perturbations are indeed frequently observed in the Developmental Origin of Health and Diseases (DOHaD) field of research which proposes that environmental perturbations during the perinatal period determine the susceptibility to pathological conditions later in life. In this review, we explored the potential influence of early environmental exposure to risk factors (maternal stress, malnutrition, xenobiotics, chemical factors … ) and the involvement of epigenetic mechanisms on the programming of late-onset AD. Animal models indicate that offspring exposed to early-life stress during gestation and/or lactation increase both AD lesions, lead to defects in synaptic plasticity and finally to cognitive impairments. This long-lasting epigenetic programming could be modulated by factors such as nutriceuticals, epigenetic modifiers or psychosocial behaviour, offering thus future therapeutic opportunity to protect from AD development.

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“…With the progress of population aging, the medical burden of AD patients increases, and AD related research expands rapidly. The etiological theory of AD is gradually getting rid of the simple hypothesis of linear causality proposed by the original amyloid hypothesis, and more and more attention is paid to the important role of epigenetics, aging and lifestyle (16,17), etc. Until now, all the drugs for treating AD can only improve the symptoms of AD, such as slowing the AD patient, etc., and cannot change the pathogenesis of the AD patient to cure AD.…”

Section: Discussionmentioning

confidence: 99%

Global Public Interest and Seasonal Variations in Alzheimer's Disease: Evidence From Google Trends

Mao

Wang

et al. 2021

Front. Med.

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Background: As the world's population ages, Alzheimer's disease (AD), a common neurodegenerative disease, is a major challenge to human health in the future. Understanding the information needs on AD of the global public can contribute to the prevention and control of AD. The purpose of this study was to explore global public interest and seasonal variations in AD using Google Trends (GT).Methods: GT was used to obtain relative search volume (RSV) of the keyword “Alzheimer's disease” in six English-speaking countries (Australia, New Zealand, the USA, the UK, Canada, and Ireland) and the world from January 2004 to December 2020. Cosinor analysis was applied to detect the seasonality of AD-related RSV. Time series plot was used to observe the trend of annual mean AD-related RSV. Globally, hot topics and top rising topics related to AD were also analyzed. In addition, we also explored the geographical distribution characteristics of AD-related RSV.Results: AD-related RSV declined steadily from January 2004 to December 2013 and rose steadily from January 2014 to December 2020. Search popularity of AD is low in the southern hemisphere, compared to the northern hemisphere. Cosinor analysis showed that there were significant seasonal variations in AD-related RSV in six English-speaking countries (all P < 0.05). Interestingly, regardless of the hemisphere, peaks were observed in the winter months and trough in the summer months. Topics related to the characteristics and etiology of AD, early onset AD, AD-related associations, care of AD patients, and diseases that can easily be confused with AD had received special attention.Conclusions: There is increasing global public interest for AD and a significant seasonal variation in AD. A better understanding of the seasonal variations and public interest of AD by governments, health workers and patients can contribute to the prevention, management, and treatment of AD.

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Epigenetics of Alzheimer’s Disease

Cited by 82 publications

References 283 publications

Oxidative Stress and Beta Amyloid in Alzheimer’s Disease. Which Comes First: The Chicken or the Egg?

Oxidative Stress and Beta Amyloid in Alzheimer’s Disease. Which Comes First: The Chicken or the Egg?

Early-Life Environment Influence on Late-Onset Alzheimer’s Disease

Global Public Interest and Seasonal Variations in Alzheimer's Disease: Evidence From Google Trends

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