Epigenetics Approaches toward Precision Medicine for Idiopathic Pulmonary Fibrosis: Focus on DNA Methylation

Effendi, Wiwin Is; Nagano, Tatsuya

doi:10.3390/biomedicines11041047

Cited by 5 publications

(4 citation statements)

References 147 publications

(161 reference statements)

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“…In addition to D f , our study also investigated the relationship between FF density and disease progression in IPF. FFs are aggregates of activated fibroblasts that are thought to play a key role in the pathogenesis of IPF by driving aberrant tissue remodeling [24][25][26]. Our finding of a significant correlation between FF density and D f is consistent with previous studies that have shown that FFs are a strong predictor of disease progression in IPF [14,27,28].…”

Section: Discussionsupporting

confidence: 90%

Histologic Analysis of Idiopathic Pulmonary Fibrosis by Morphometric and Fractal Analysis

Mancini¹,

Bargiacchi²,

Vitis

et al. 2023

Biomedicines

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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disorder, ultimately leading to respiratory failure and death. Despite great research advances in understanding the mechanisms underlying the disease, its diagnosis, and its treatment, IPF still remains idiopathic without known biological or histological markers able to predict disease progression or response to treatment. The histologic hallmark of IPF is usual interstitial pneumonia (UIP), with its intricate architectural distortion and temporal inhomogeneity. We hypothesize that normal lung alveolar architecture can be compared to fractals, such as the Pythagoras tree with its fractal dimension (Df), and every pathological insult, distorting the normal lung structure, could result in Df variations. In this study, we aimed to assess the UIP histologic fractal dimension in relationship to other morphometric parameters in newly diagnosed IPF patients and its possible role in the prognostic stratification of the disease. Clinical data and lung tissue specimens were obtained from twelve patients with IPF, twelve patients with non-specific interstitial pneumonia (NSIP), and age-matched “healthy” control lung tissue from patients undergoing lung surgery for other causes. Histology and histomorphometry were performed to evaluate Df and lacunarity measures, using the box counting method on the FracLac ImageJ plugin. The results showed that Df was significantly higher in IPF patients compared to controls and fibrotic NSIP patients, indicating greater architectural distortion in IPF. Additionally, high Df values were associated with higher fibroblastic foci density and worse prognostic outcomes in IPF, suggesting that Df may serve as a potential novel prognostic marker for IPF. The scalability of Df measurements was demonstrated through repeated measurements on smaller portions from the same surgical biopsies, which were selected to mimic a cryobiopsy. Our study provides further evidence to support the use of fractal morphometry as a tool for quantifying and determining lung tissue remodeling in IPF, and we demonstrated a significant correlation between histological and radiological Df in UIP pattern, as well as a significant association between Df and FF density. Furthermore, our study demonstrates the scalability and self-similarity of Df measurements across different biopsy types, including surgical and smaller specimens.

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Section: Discussionsupporting

confidence: 90%

Histologic Analysis of Idiopathic Pulmonary Fibrosis by Morphometric and Fractal Analysis

Mancini¹,

Bargiacchi²,

Vitis

et al. 2023

Biomedicines

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“…According to certain recent studies, epigenetic control of structural and immunological cells within wounds may affect the healing process and cell phenotypes in individuals with diabetes [ 11 ]. Epigenetics will help with precision medicine approaches to diabetic wound healing [ 12 , 13 ]. Epigenetics is the study of non-heritable and heritable genetic coding [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic modification: A novel insight into diabetic wound healing

Ju,

Liu,

Liu

et al. 2024

Heliyon

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“…Changes in DNMT activity due to H 2 S dysregulation have been associated with altered DNA methylation patterns in neurons, contributing to the aberrant gene expression observed in NDs. For instance, H 2 S-mediated changes in DNA methylation have been linked to the dysregulation of genes involved in neuroinflammation, oxidative stress, and neuronal survival [ 70 , 71 , 72 , 73 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

Dogaru

Munteanu

2023

IJMS

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This review explores the emerging role of hydrogen sulfide (H2S) in modulating epigenetic mechanisms involved in neurodegenerative diseases. Accumulating evidence has begun to elucidate the multifaceted ways in which H2S influences the epigenetic landscape and, subsequently, the progression of various neurodegenerative disorders, including Alzheimer’s, Parkinson’s, and Huntington’s disease. H2S can modulate key components of the epigenetic machinery, such as DNA methylation, histone modifications, and non-coding RNAs, impacting gene expression and cellular functions relevant to neuronal survival, inflammation, and synaptic plasticity. We synthesize recent research that positions H2S as an essential player within this intricate network, with the potential to open new therapeutic avenues for these currently incurable conditions. Despite significant progress, there remains a considerable gap in our understanding of the precise molecular mechanisms and the potential therapeutic implications of modulating H2S levels or its downstream targets. We conclude by identifying future directions for research aimed at exploiting the therapeutic potential of H2S in neurodegenerative diseases.

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Epigenetics Approaches toward Precision Medicine for Idiopathic Pulmonary Fibrosis: Focus on DNA Methylation

Cited by 5 publications

References 147 publications

Histologic Analysis of Idiopathic Pulmonary Fibrosis by Morphometric and Fractal Analysis

Histologic Analysis of Idiopathic Pulmonary Fibrosis by Morphometric and Fractal Analysis

Epigenetic modification: A novel insight into diabetic wound healing

The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review

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