Epigenetics and Oxidative Stress in Aging

Guillaumet-Adkins, Amy; Yáñez, Yania; Peris‐Díaz, Manuel David; Calabria, Inés; Palanca-Ballester, Cora; Sandoval, Juan

doi:10.1155/2017/9175806

Cited by 142 publications

(100 citation statements)

References 88 publications

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“…Numerous research studies suggest that oxidative stress has an important role in the process of aging. Accumulation of oxidative damage to cell and tissue over the lifespan leads to aging . Several evidences show that antioxidant supplements including resveratrol, are useful in delaying the aging process .…”

Section: The Effect Of Resveratrol On Aging Biomarkersmentioning

confidence: 99%

Effect of resveratrol and pterostilbene on aging and longevity

2017

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Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as antiaging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence. In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and highcalorie diets. Moreover, we also discuss the positive effect of Abbreviations: ABTS, 2,2 0 -Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid; Akt, v-akt murine thymoma viral oncogene; AMPK, AMP-activated kinase; ARE, antioxidant response element; C. elegans, Caenorhabditis elegans; cAMP, cyclic adenosine monophosphate; CCL3, C-C motif chemokine ligand 3; CNS, central nervous system; CREB, cAMP response element binding protein; CRP, c-reactive protein; DPPH, 2,2-diphenyl-1-picryl-hydrazyl; eNOS, endothelial nitric oxide synthase; ERK, extracellular-signal-regulated kinase; ER-a, estrogen receptor alpha; FOXO1, forkhead box protein O1; FOXO3, forkhead box O3A protein; GSH, glutathione; GSH-Px, glutathione peroxidase; GSK3b, glycogen synthase kinase 3 b; hTERT, human telomerase reverse transcriptase; HtrA2, HtrA serine peptidase 2; IDH2, dehydrogenase 2; IFN-c, interferon gamma; IL-18, interleukin-18; IL-1b, interleukin 1 b; IL-6, interleukin-6; LDL, low-density lipoprotein; LPS, lipopolysaccharides; MAPK, mitogen-activated protein kinase; MLC, myosin light chain; MMP-1, matrix metalloproteinase-1; MMP-2, matrix metalloproteinase-2; MMP-9, matrix metalloproteinase-9; MnSOD, manganese superoxide dismutase; mRNA, messenger RNA; mtROS, mitochondrial reactive oxygen species; NADPH, nicotinamide adenine dinucleotide phosphate; NALP-3, NACHT 5 LRR and PYD domainscontaining protein 3; NAMPT, nicotinamide phosphoribosyltransferase; NFAT, nuclear factor of activated T-cells; NF-rB, nuclear factor-jB; NO, nitric oxide; Nrf2, nuclear factor erythroid 2-related factor 2; NS, Nutritional Supplement; OA, osteoarthritis; oxoLDL, oxidized low-density lipoprotein; PARK7, Parkinson disease protein 7; PARKIN, parkinson juvenile disease protein; PGC-1a, peroxisome proliferator-activated receptor gamma coactivator 1-a; PINK1, PTEN-induced putative kinase 1; PKB, protein kinase B; RhoA, Ras homolog gene family 5 member A; ROCK2, Rho-associated 5 coiled-coil containing protein kinase 2; ROS, reactive oxygen species; SAMP8, senescence accelerated mouse-prone 8; SCID, severe combined immunodeficiency; SHR, spontaneously hypertensive rat; SIRT1, sirtuin 1; SIRT4, sirtuin 4; SOD, superoxide peroxidase; STZ, streptozotocin; T2D, type 2 diabetes; TIMP-1, TIMP metallopeptidase inhibitor 1; TLR5, toll-like receptor 5; TNF-a, tumor necrosis factor alpha; UVB, ultraviol...

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Section: The Effect Of Resveratrol On Aging Biomarkersmentioning

confidence: 99%

Effect of resveratrol and pterostilbene on aging and longevity

2017

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“…The current advancement in precision medical research has paved the way to explore aging and epigenetic modification of aging-related genes [35]. For instance, serum levels of LEP were found to be high in aging and obesity-related diseases like obstructive sleep apnea (OSA) and Alzheimer's disease [36,37].…”

Section: Discussionmentioning

confidence: 99%

Interaction of Osteoarthritis and BMI on Leptin Promoter Methylation in Taiwanese Adults

Yang

Chen

et al. 2019

IJMS

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Leptin (LEP) regulates glucose metabolism and energy storage in the body. Osteoarthritis (OA) is associated with the upregulation of serum LEP. LEP promoter methylation is associated with obesity. So far, few studies have explored the association of BMI and OA with LEP methylation. We assessed the interaction between body mass index (BMI) and OA on LEP promoter methylation. Data of 1114 participants comprising 583 men and 558 women, aged 30–70 years were retrieved from the Taiwan Biobank Database (2008–2015). Osteoarthritis was self-reported and cases were those who reported having ever been clinically diagnosed with osteoarthritis. BMI was categorized into underweight, normal weight, overweight, and obesity. The mean LEP promoter methylation level in individuals with osteoarthritis was 0.5509 ± 0.00437 and 0.5375 ± 0.00101 in those without osteoarthritis. The interaction between osteoarthritis and BMI on LEP promoter methylation was significant (p-value = 0.0180). With normal BMI as the reference, the mean LEP promoter methylation level was significantly higher in obese osteoarthritic individuals (β = 0.03696, p-value = 0.0187). However, there was no significant association between BMI and LEP promoter methylation in individuals without osteoarthritis, regardless of BMI. In conclusion, only obesity was significantly associated with LEP promoter methylation (higher levels) specifically in osteoarthritic patients.

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“…Oxidation of 5-methylcytosine (5mC) due to Ten-Eleven Translocation (TET) proteins leads to 5-hydroxymethylcytosine (5hmC) formation which is deaminated to 5hydroxymethyluracil and then replaced with unmethylated cytosine [68]. Oxidative stress can also inhibit the NAD + dependent deacetylase SIRT1 that controls inflammatory responses, lipid storage, telomerase activity, mitochondrial respiration and ROS production [69,70]. In this context, a highfat/glucose diet that decreases NAD + content can negatively regulate Sirtuin activity.…”

Section: Epigenetics and Posttranslational Protein Modification Modulmentioning

confidence: 99%

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Cherkas¹,

Holota²,

Mdzinarashvili³

et al. 2020

Preprint

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A human organism depends on stable glucose blood levels in order to maintain the metabolic needs. Glucose is considered as the most important energy source and glycolysis is postulated as a backbone pathway. However, when glucose supply is limited, ketone bodies and amino acids can be used to produce enough ATP. In contrast, for the functioning of pentose phosphate pathway (PPP) glucose is essential and cannot be substituted by other metabolites. PPP generates and maintains levels of NADPH needed for reduction of oxidized glutathione and protein thiols, synthesis of lipids and DNA as well as for xenobiotic detoxification, regulatory redox signaling and counteracting infections. Flux of glucose into a PPP, particularly under extreme oxidative and toxic challenges is critical for survival, whereas the glycolytic pathway is primarily activated when glucose is abundant, and there is lack of NADP+ that is required for activation of glucose-6 phosphate dehydrogenase. An important role of glycogen stores in resistance to oxidative challenges is discussed. Current evidences explain disruptive metabolic effects and detrimental health consequences of chronic nutritional carbohydrate overload and provides new insights into positive metabolic effects of intermittent fasting, caloric restriction, exercise, and ketogenic diet through modulation of redox homeostasis.

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Epigenetics and Oxidative Stress in Aging

Cited by 142 publications

References 88 publications

Effect of resveratrol and pterostilbene on aging and longevity

Effect of resveratrol and pterostilbene on aging and longevity

Interaction of Osteoarthritis and BMI on Leptin Promoter Methylation in Taiwanese Adults

Glucose as a Major Antioxidant: When, What for and Why It Fails?

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