Epigenetic regulation of mammalian genomic imprinting

Delaval, Katia; Feil, Robert

doi:10.1016/j.gde.2004.01.005

Cited by 345 publications

(257 citation statements)

References 56 publications

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“…Those in the same cluster are usually regulated by the same imprinting control region (ICR) [3]. Several mechanisms are involved in the control of allelic expression, including DNA allelic methylation, noncoding RNA and/or histone modifications [4]. Genomic imprinting is an evolutionary puzzle because monoallelic expression can expose deleterious recessive mutations, which are normally protected by diploidy [5].…”

Section: Introductionmentioning

confidence: 99%

Effects of maternal nutrition on the expression of genomic imprinted genes in ovine fetuses

et al. 2018

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Genomic imprinting is an epigenetic phenomenon of differential allelic expression based on parental origin. To date, 263 imprinted genes have been identified among all investigated mammalian species. However, only 21 have been described in sheep, of which 11 are annotated in the current ovine genome. Here, we aim to i) use DNA/RNA high throughput sequencing to identify new monoallelically expressed and imprinted genes in day 135 ovine fetuses and ii) determine whether maternal diet (100%, 60%, or 140% of National Research Council Total Digestible Nutrients) influences expression of imprinted genes. We also reported strategies to solve technical challenges in the data analysis pipeline. We identified 80 monoallelically expressed, 13 new putative imprinted genes, and five known imprinted genes in sheep using the 263 genes stated above as a guide. Sanger sequencing confirmed allelic expression of seven genes, CASD1, COPG2, DIRAS3, INPP5F, PLAGL1, PPP1R9A, and SLC22A18. Among the 13 putative imprinted genes, five were localized in the known sheep imprinting domains of MEST on chromosome 4, DLK1/GTL2 on chromosome 18 and KCNQ1 on chromosome 21, and three were in a novel sheep imprinted cluster on chromosome 4, known in other species as PEG10/SGCE. The expression of DIRAS3, IGF2, PHLDA2, and SLC22A18 was altered by maternal diet, albeit without allelic expression reversal. Together, our results expanded the list of sheep imprinted genes to 34 and demonstrated that while the expression levels of four imprinted genes were changed by maternal diet, the allelic expression patterns were un-changed for all imprinted genes studied.

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Section: Introductionmentioning

confidence: 99%

Effects of maternal nutrition on the expression of genomic imprinted genes in ovine fetuses

et al. 2018

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“…histone methylation and acetylation). (7) Most ICRs are less than a few kilobases in size and comprise sequences that are rich in CpG dinucleotides (many are CpG islands). Their allele-specific DNA methylation is established in either the male or the female germline and, after fertilisation, is maintained throughout development.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic deregulation of imprinting in congenital diseases of aberrant growth

2006

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“…Imprinted genes usually occur in clusters of 3-11 genes. Two noncoding RNAs that silence their respective ICRs are Air in the Igf2r cluster and Kcnq1ot1 in the Kcnq1 cluster (Delaval and Feil, 2004). Genes in the Igf2r and Kcnq1 clusters are expressed on the maternal chromosome and encode a fetal growth regulator and cardiac potassium channel, respectively.…”

Section: Genomic Imprintingmentioning

confidence: 99%

Epigenetics in development

Kiefer

2007

Developmental Dynamics

234

144

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It has become increasingly evident in recent years that development is under epigenetic control. Epigenetics is the study of heritable changes in gene function that occur independently of alterations to primary DNA sequence. The best-studied epigenetic modifications are DNA methylation, and changes in chromatin structure by histone modifications, and histone exchange. An exciting, new chapter in the field is the finding that long-distance chromosomal interactions also modify gene expression. Epigenetic modifications are key regulators of important developmental events, including X-inactivation, genomic imprinting, patterning by Hox genes and neuronal development. This primer covers these aspects of epigenetics in brief, and features an interview with two epigenetic scientists. Developmental Dynamics 236: 1144 -1156, 2007.

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Epigenetic regulation of mammalian genomic imprinting

Cited by 345 publications

References 56 publications

Effects of maternal nutrition on the expression of genomic imprinted genes in ovine fetuses

Effects of maternal nutrition on the expression of genomic imprinted genes in ovine fetuses

Epigenetic deregulation of imprinting in congenital diseases of aberrant growth

Epigenetics in development

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