Epigenetic Regulation of Human Cytomegalovirus Latency: an Update

Kumar, Amit; Herbein, Georges

doi:10.2217/epi.14.41

Cited by 20 publications

(18 citation statements)

References 151 publications

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“…After primary infection, CMV undergoes latency in the human body through a series of immune escape strategies (6,7,21). CMV infection is well controlled in immunocompetent hosts.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus hepatitis in 49 pediatric patients with normal immunity

Tezer¹,

Yüksek²,

Gülhan³

et al. 2016

Turk J Med Sci

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Background/aim: Cytomegalovirus (CMV) hepatitis is generally asymptomatic or rarely can lead to severe complications in immunocompetent hosts. This study aims to evaluate CMV hepatitis in immunocompetent young children, which is discussed relatively rarely in the literature. Materials and methods:A retrospective review of 49 pediatric patients with CMV hepatitis from January 2005 to December 2010 was performed. Results:The median age of the patients was 5.81 ± 6.49 months and 57.1% were female. Complaints were prolonged jaundice, vomiting, diarrhea, and abdominal distension. Seventeen patients (34.6%) had congenital or probable congenital CMV infection, while 32/49 (65.3%) had perinatal CMV infection. CMV hepatitis was accompanied by other system findings in 22 patients (44.9%), and only liver involvement was present in 27/49 (55.1%). Alanine aminotransferase and aspartate aminotransferase were elevated together in all patients. Cholestatic hepatitis was present in 13 patients (26.5%). Four patients (8.16%) were treated with ganciclovir. Complete improvement of hepatitis occurred in 48/49 (97.95%). The recovery time of liver function tests was 7-180 days (mean: 53.92 ± 40.8). Conclusion:CMV hepatitis is usually mild and has a good outcome in immunocompetent individuals. However, cases should be carefully evaluated due to the important role of CMV in the etiology of infantile and neonatal hepatitis.

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“…After primary infection, CMV undergoes latency in the human body through a series of immune escape strategies (6,7,21). CMV infection is well controlled in immunocompetent hosts.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus hepatitis in 49 pediatric patients with normal immunity

Tezer¹,

Yüksek²,

Gülhan³

et al. 2016

Turk J Med Sci

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“…, and signaling coreceptors [67,82] Noncoding RNAs (including miRNAs) [41,42,48] Proteins interacting with oriLyts [51] Interferons and other cytokines [30,[32][33][34] Sensors of viral infection [23,83,84] Cell cycle proteins [62,85,86] Proteins regulating apoptosis [87][88][89][90] Transcription factors [91] DNA damage response proteins [5] Proteins involved in epigenetic gene regulation including chromatin assembly, histone modifications[ 3 _ T D $ D I F F ] , and DNA methylation [21][22][23][24][25][26][27][28]63,[92][93][94][95][96][97][98] Autophagy and xenophagy [99][100][101] Ubiquitination and NEDDylation [102][103][104][105] Chaperones [65] Post-translational modification proteins …”

Section: Key Figurementioning

confidence: 99%

Herpesviruses and Their Host Cells: A Successful Liaison

Adler

Christine

Adler

2017

Trends in Microbiology

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During a long history of coevolution, herpesviruses have reached a fine-tuned balance with their hosts, allowing them to successfully persist and spread to new hosts without causing too much damage. Only under certain circumstances, as in neonates or immunocompromised individuals, they may cause serious diseases. The delicate balance between herpesviruses and their hosts results from interactions of a great variety of viral and cellular factors which together shape the tropism for a particular host, tissue, or cell. Understanding these interactions will provide insight into the viral life cycle and cell biology in general. Moreover, it will also facilitate comprehension of herpesvirus pathogenesis, enabling the development of new strategies to combat herpesviruses in cases where they cause disease.

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“…Upon primary infection it establishes latent infection in a few cells. However, in certain situations where immunity is either immature or compromised, HCMV may reactivate and cause mortality and morbidity [35]. The mechamism of infection and reactivation of HCMV have been reported [35].…”

Section: Pathogenesis and Pathology Of CMVmentioning

confidence: 99%