Epigenetic Modulation by Methionine Deficiency Attenuates the Potential for Gastric Cancer Cell Dissemination

Graziosi, Luigina; Mencarelli, Andrea; Renga, Barbara; D’Amore, Claudio; Bruno, Angela M.; Santorelli, Chiara; Cavazzoni, Emanuel; Cantarella, Francesco; Rosati, Emanuele; Donini, Annibale; Fiorucci, Stefano

doi:10.1007/s11605-012-1996-1

Cited by 14 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have shown that human tumors, including those derived from the nervous system such as glioblastoma, medulloblastoma, neuroblastoma and gastric cancer are much more sensitive than normal tissues to L‐methionine starvation and L‐methionine is also required for polymanine synthesis (Kreis and Goodenow ; Thomas and Thomas ; Graziosi et al . ; Stone et al . ).…”

Section: Resultsmentioning

confidence: 99%

Thermal Stability of Chicken Keel Bone Collagen

Losso

Ogawa

2013

Journal of Food Biochemistry

View full text Add to dashboard Cite

Acid‐soluble and pepsin‐solubilized collagen were isolated from chicken keel bone and analyzed by electrophoresis and circular dichroism. The denaturation temperature of chicken keel bone was determined by circular dichroism and compared to denaturation temperature of black drum or alligator bone. Our results show that collagen from chicken keel bone is a mixture of type II and type I, has predominantly the amino acids glycine, proline and hydroxyproline, and its secondary structure is predominantly triple‐helix. The onset of the denaturation temperature is 37C; at 44C, 50% of the collagen is denatured and the denaturation is complete at 48.8C making it the highest of vertebrate collagen denaturation temperatures reported in the literature. The high heat stability of chicken keel bone collagen may be in part ascribed to its imino acid content. Because of the high heat stability and low methionine content, chicken keel bone collagen is a high value‐added product with several biochemical and biomedical applications. Practical Applications The denaturation temperature of chicken keel bone collagen is above body temperature and allows applications in cosmetics where other types of collagen may be denatured because of their low denaturation temperature. Chicken type II collagen is well tolerated by patients with rheumatoid arthritis and is effective in the treatment of rheumatoid arthritis. Methionine‐restricted diet inhibits the growth of solid tumor such as gastric cancer, glioblastoma, medulloblastoma and neuroblastoma. Chicken type collagen may be a medical food for patients with solid tumors mentioned above.

show abstract

Section: Resultsmentioning

confidence: 99%

Thermal Stability of Chicken Keel Bone Collagen

Losso

Ogawa

2013

Journal of Food Biochemistry

View full text Add to dashboard Cite

show abstract

“…Рацион с дефицитом метионина тормозил рост опухоли в модели перитонеального карциноматоза после трансплантации клеток рака желудка MNK45 и MNK74 мышам NOD-SCID. В каче-стве одной из причин полученного эффекта авторы считают угнетение метилирования промотора гена Е-кадгерина [90].…”

Section: возможность использования рациона со сниженным содержанием мunclassified

Pathological Metabolism of Methionine in Malignant Cells Is a Potential Target for the Antitumor Therapy

VS¹,

Davydov²,

Anufrieva³

et al. 2017

Клиническая онкогематология

View full text Add to dashboard Cite

This review presents the characteristics of the cellular metabolism of methionine, as well as known data on the mechanisms of the development of methionine dependence in malignant cells. The possibilities of using a non-methionine diet for the control of the tumor growth in patients with various forms of cancer are considered. The information about methionine Y-lyase, an enzyme providing elimination of methionine from plasma, is provided. Its role as a potential antitumor enzyme is disclosed. Data on cytotoxic activity of the enzyme, obtained from various sources, and information on tumor models and cell cultures, showing methionine dependence are summarised.

show abstract

“…Nonetheless, a study suggests that dietary methionine supplementation in rodents significantly increases methylation levels and prevents gamma-radiation-induced-global DNA hypomethylation [45]. A methionine-deficient diet modulates the growth of gastric tumor cells and in vitro deficiency of methionine increases apoptosis rate and decreases cellular adhesion and migration associated with decreased E-cadherin promoter methylation and increased gene expression, in vitro and in vivo [47]. A methionine-deficient diet modulates the growth of gastric tumor cells and in vitro deficiency of methionine increases apoptosis rate and decreases cellular adhesion and migration associated with decreased E-cadherin promoter methylation and increased gene expression, in vitro and in vivo [47].…”

Section: Methioninementioning

confidence: 99%