2007
DOI: 10.1002/jcp.21066
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Epigenetic drugs as pleiotropic agents in cancer treatment: Biomolecular aspects and clinical applications

Abstract: In the last three decades huge efforts have been made to characterize genetic defects responsible for cancer development and progression, leading to the comprehensive identification of distinct cellular pathways affected by the alteration of specific genes. Despite the undoubtable role of genetic mechanisms in triggering neoplastic cell transformation, epigenetic modifications (i.e., heritable changes of gene expression that do not derive from alterations of the nucleotide sequence of DNA) are rapidly emerging… Show more

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Cited by 137 publications
(136 citation statements)
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“…Epigenetic modifications affect the arrangement in gene expression by two main mechanisms: methylation of CpG rich islands present in the genomic DNA (Romano, Micheli, Pacilio & Giordano, 2000;Sigalotti et al, 2007) and methylation and/or acetylation of histones H3 and H4 (Jones & Baylin, 2002;Sparmann & van Lohuizen, 2006). Both events do not affect the DNA sequence at all and, yet, they have important implications on the regulation of transcriptional activity.…”
Section: From Genetic To Epigenetic and Genomic Medicine: New Frontlimentioning
confidence: 99%
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“…Epigenetic modifications affect the arrangement in gene expression by two main mechanisms: methylation of CpG rich islands present in the genomic DNA (Romano, Micheli, Pacilio & Giordano, 2000;Sigalotti et al, 2007) and methylation and/or acetylation of histones H3 and H4 (Jones & Baylin, 2002;Sparmann & van Lohuizen, 2006). Both events do not affect the DNA sequence at all and, yet, they have important implications on the regulation of transcriptional activity.…”
Section: From Genetic To Epigenetic and Genomic Medicine: New Frontlimentioning
confidence: 99%
“…So far, four types of DNA methyltransferases (DNMT) that mediate the methylation of CpG islands have been identified: DNMT1, DNMT2, DNMT3a and DNMT3b (Sigalotti et al, 2007).…”
Section: From Genetic To Epigenetic and Genomic Medicine: New Frontlimentioning
confidence: 99%
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