Epigenetic aspects in schizophrenia etiology and pathogenesis

Popov, Nikolay T.; Stoyanova, Vili K.; Madzhirova, Nadezhda P.; Vachev, Tihomir

doi:10.2478/v10153-011-0082-x

Cited by 16 publications

(9 citation statements)

References 25 publications

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“…The covalent binding of a methyl group to the 5′ end of cytosine in DNA CpG dinucleotides can silence the gene and inhibit gene expression [7]. It has been proposed that measuring DNA methylation changes may provide a better measure of environmental impacts than evaluating environmental factors themselves [8, 9]. Due to their dependence on genetic and environmental factors, epigenetic markers integrate information from both causal contributors to phenotypes.…”

Section: Introductionmentioning

confidence: 99%

Associations between DNA methylation and schizophrenia-related intermediate phenotypes — A gene set enrichment analysis

Hass

Walton

Wright

et al. 2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Multiple genetic approaches have identified microRNAs as key effectors in psychiatric disorders as they post-transcriptionally regulate expression of thousands of target genes. However, their role in specific psychiatric diseases remains poorly understood. In addition, epigenetic mechanisms such as DNA methylation, which affect the expression of both microRNAs and coding genes, are critical for our understanding of molecular mechanisms in schizophrenia. Using clinical, imaging, genetic, and epigenetic data of 103 patients with schizophrenia and 111 healthy controls of the Mind Clinical Imaging Consortium (MCIC) study of schizophrenia, we conducted gene set enrichment analysis to identify markers for schizophrenia-associated intermediate phenotypes. Genes were ranked based on the correlation between DNA methylation patterns and each phenotype, and then searched for enrichment in 221 predicted microRNA target gene sets. We found the predicted hsa-miR-219a-5p target gene set to be significantly enriched for genes (EPHA4, PKNOX1, ESR1, amongst others) whose methylation status is correlated with hippocampal volume independent of disease status. Our results were strengthened by significant associations between hsa-miR-219a-5p target gene methylation patterns and hippocampus-related neuropsychological variables. IPA pathway analysis of the respective predicted hsa-miR-219a-5p target genes revealed associated network functions in behaviour and developmental disorders. Altered methylation patterns of predicted hsa-miR-219a-5p target genes are associated with a structural aberration of the brain that has been proposed as a possible biomarker for schizophrenia. The (dys)regulation of microRNA target genes by epigenetic mechanisms may confer additional risk for developing psychiatric symptoms. Further study is needed to understand possible interactions between microRNAs and epigenetic changes and their impact on risk for brain-based disorders such as schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Associations between DNA methylation and schizophrenia-related intermediate phenotypes — A gene set enrichment analysis

Hass

Walton

Wright

et al. 2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Epidemiological evidence suggests that the etiology of schizophrenia may involve both the influence of genetic factors specific to the individual and the impact of the environment. It is quite likely that a crucial role in disease development is played by molecular mechanisms mediating the interaction between genes and the environment [Popov et al 2012]. Until recently, little was known about the role of vitamin D in brain function.…”

Section: Introductionmentioning

confidence: 99%

Correlation between total vitamin D levels and psychotic psychopathology in patients with schizophrenia: therapeutic implications for add-on vitamin D augmentation

Yüksel

Altunsoy

Tıkır

et al. 2014

Therapeutic Advances in Psychopharmacology

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Even though important factors for vitamin D synthesis were similar, there was severe vitamin D deficiency in patients presenting with an acute episode, significantly different from those in remission. Is vitamin D deficiency the result or the cause of an acute episode? Our results contribute to the idea that vitamin D deficiency and schizophrenia may have interactions with an unknown pathway. Present data points out a possible influence at a genomic level. Future trials may investigate this association with longer follow up. We recommend that, serum vitamin D levels should be measured in patients with schizophrenia especially in long term care. Appropriate further treatment with add-on vitamin D supplements and diets that are rich in vitamin D should be considered.

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“…Abu-Elneel et al identified 28 miRNAs (out of 466 miRNAs examined) that were differentially expressed between autism and control in a postmortem brain analysis [256]. The differential expression of miRNAs in autistic individuals was also examined in whole blood and lymphoblastoid cell samples [257,258].…”

Section: Micrornasmentioning

confidence: 99%

Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder

Yoon

Choi

Lee

et al. 2020

JCM

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Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by difficulties in social interaction, language development delays, repeated body movements, and markedly deteriorated activities and interests. Environmental factors, such as viral infection, parental age, and zinc deficiency, can be plausible contributors to ASD susceptibility. As ASD is highly heritable, genetic risk factors involved in neurodevelopment, neural communication, and social interaction provide important clues in explaining the etiology of ASD. Accumulated evidence also shows an important role of epigenetic factors, such as DNA methylation, histone modification, and noncoding RNA, in ASD etiology. In this review, we compiled the research published to date and described the genetic and epigenetic epidemiology together with environmental risk factors underlying the etiology of the different phenotypes of ASD.

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Epigenetic aspects in schizophrenia etiology and pathogenesis

Cited by 16 publications

References 25 publications

Associations between DNA methylation and schizophrenia-related intermediate phenotypes — A gene set enrichment analysis

Associations between DNA methylation and schizophrenia-related intermediate phenotypes — A gene set enrichment analysis

Correlation between total vitamin D levels and psychotic psychopathology in patients with schizophrenia: therapeutic implications for add-on vitamin D augmentation

Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder

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