Correlation between total vitamin D levels and psychotic psychopathology in patients with schizophrenia: therapeutic implications for add-on vitamin D augmentation

Yüksel, Rabia Nazik; Altunsoy, Neslihan; Tıkır, Baise; Külük, Merve Cingi; Ünal, Kübranur; Goka, Sema; Aydemir, Çiğdem; Göka, Erol

doi:10.1177/2045125314553612

Cited by 61 publications

(56 citation statements)

References 21 publications

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“…This high proportion of patients with low S-25 OH D is of importance since this might influence morbidity both related to depressive (Berg et al, 2010), positive (Yuksel et al, 2014), negative (Graham et al, 2014) or atypical symptoms (Dealberto, 2013). There were no significant correlations between S-25 OH D and positive or negative symptomatology in the current study, but there was a moderate association between low S-25 OH D and increased depressive symptomatology in the FEP group.…”

Section: Discussioncontrasting

confidence: 61%

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

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Vitamin D deficiency is common among patients with psychotic disorders and could be due to unknown disease mechanisms or contingent factors. However most studies are performed in chronic patients and have often failed to address the influence of ethnicity on vitamin D levels in clinical samples. We investigated serum concentrations of 25-hydroxy vitamin D (S-25 OH D) in first episode patients compared to patients with multi episodes and healthy controls; with a specific focus on differences between visible ethnic minorities and participants from the majority population. A total of 284 participants were included in this cross-sectional study. First episode patients with a DSM-IV psychotic disorder were matched on age, gender and ethnicity to participants from a multi episode patient sample (1:1) and healthy controls (1:2). We did not find any differences between either patient groups or the healthy controls, but participants from visible ethnic minorities had significantly lower S-25 OH D than participants from the majority population. This implies that S-25 OH D should be routinely measured in persons from visible ethnic minorities since low levels are associated with higher levels of depressive symptoms.

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Section: Discussioncontrasting

confidence: 61%

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Nerhus

Berg

Dahl

et al. 2015

Psychiatry Research

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“…In fact, Lebanon is located at appropriate latitudes (33° 35'N) [38] for the synthesis of vitamin D [39] and thus, higher levels of total vitamin D would be expected [39]. Furthermore, our results indicated that patients with schizophrenia, as well as the healthy ones, had a vitamin D deficiency, similar to previous studies [2,4,36,37,40,41]. Other studies conducted in Lebanon had shown a hypovitaminosis D in the healthy population [35,[42][43][44][45].…”

Section: Discussionsupporting

confidence: 80%

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Azar¹

2017

Ann Nutr Disord & Ther

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Objectives: To compare the vitamin D status in schizophrenics to that of healthy controls; secondary objectives were to assess the correlation between severe vitamin D deficiency and the severity of schizophrenia symptoms and to evaluate the potential factors influencing this status. Methods:A case-control study, conducted between March and July 2016, recruited 100 patients with schizophrenia and 100 controls with no known psychiatric disorders and matched for age and sex.Results: Schizophrenic patients had a more severe vitamin D deficiency compared to healthy controls (9% vs. 3%). Vitamin D insufficiency was found in 28% of schizophrenic patients compared to 37% in healthy controls (p=0.053). BCRS and MRSS scales were significantly associated with a more severe vitamin D deficiency (p=0.006). We couldn't detect any association between the total PANSS score and its three subscales with vitamin D deficiency (p>0.05). Lebanon has a high prevalence of 25(OH)-D deficiency in adults and older adults [23,24] however, data regarding vitamin D levels in psychiatric patients is still lacking. Therefore, the primary objective of this study was to compare the vitamin D status in schizophrenics to that of healthy controls; secondary objectives were to assess the

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“…Interestingly, low serum vitamin D levels, correlating with the severity of phsychotic symptoms, have been found in SZ patients [Yüksel et al, 2014]. The molecular background of this link may rely on shared features of latitude adaptation observed in both SZ-and vitamin D-related genes, suggesting that SZ etiopathogenesis may encounter latitudedependent adaptive changes in vitamin D metabolism [Amato et al, 2010].…”

Section: Other Featuresmentioning

confidence: 99%

Schizophrenia and Human Self-Domestication: An Evolutionary Linguistics Approach

et al. 2017

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Schizophrenia (SZ) is a pervasive neurodevelopmental disorder that entails social and cognitive deficits, including marked language problems. Its complex multifactorial etiopathogenesis, including genetic and environmental factors, is still widely uncertain. SZ incidence has always been high and quite stable in human populations, across time and regardless of cultural implications, for unclear reasons. It has been hypothesized that SZ pathophysiology may involve the biological components that changed during the recent human evolutionary history, and led to our distinctive mode of cognition, which includes language skills. In this paper we explore this hypothesis, focusing on the self-domestication of the human species. This has been claimed to account for many human-specific distinctive traits, including aspects of our behavior and cognition, and to favor the emergence of complex languages through cultural evolution. The “domestication syndrome” in mammals comprises the constellation of traits exhibited by domesticated strains, seemingly resulting from the hypofunction of the neural crest. It is our intention to show that people with SZ exhibit more marked domesticated traits at the morphological, physiological, and behavioral levels. We also show that genes involved in domestication and neural crest development and function comprise nearly 20% of SZ candidates, most of which exhibit altered expression profiles in the brain of SZ patients, specifically in areas involved in language processing. Based on these observations, we conclude that SZ may represent an abnormal ontogenetic itinerary for the human faculty of language, resulting, at least in part, from changes in genes important for the domestication syndrome and primarily involving the neural crest.

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Correlation between total vitamin D levels and psychotic psychopathology in patients with schizophrenia: therapeutic implications for add-on vitamin D augmentation

Cited by 61 publications

References 21 publications

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Vitamin D status in psychotic disorder patients and healthy controls – The influence of ethnic background

Vitamin D Levels in Lebanese Patients with Schizophrenia: A Case-Control Study

Schizophrenia and Human Self-Domestication: An Evolutionary Linguistics Approach

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