Epigenetic: A new approach to etiology of infertility

Lestari, Silvia Werdhy; Rizki, Meidika Dara

doi:10.13181/mji.v25i4.1504

Cited by 7 publications

(6 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epigenetics is described as heritable changes in gene expression or cellular phenotype, which take place with no changes to the underlying DNA sequence mitotically and meiotically [ 160 ]. According to Lestari and Rizki [ 161 ], DNA methylation, histone modifications and chromatin remodeling are the primary epigenetic mechanisms, which also include gene expression regulation. DNA hypomethylation correlates with gene expression, while hypermethylation is correlated with gene silencing.…”

Section: Mechanisms Of Benzene-induced In Utero Carcinogenicity Invol...mentioning

confidence: 99%

Linking Benzene, in Utero Carcinogenicity and Fetal Hematopoietic Stem Cell Niches: A Mechanistic Review

Yusoff

Hamid

Budin

et al. 2023

IJMS

View full text Add to dashboard Cite

Previous research reported that prolonged benzene exposure during in utero fetal development causes greater fetal abnormalities than in adult-stage exposure. This phenomenon increases the risk for disease development at the fetal stage, particularly carcinogenesis, which is mainly associated with hematological malignancies. Benzene has been reported to potentially act via multiple modes of action that target the hematopoietic stem cell (HSCs) niche, a complex microenvironment in which HSCs and multilineage hematopoietic stem and progenitor cells (HSPCs) reside. Oxidative stress, chromosomal aberration and epigenetic modification are among the known mechanisms mediating benzene-induced genetic and epigenetic modification in fetal stem cells leading to in utero carcinogenesis. Hence, it is crucial to monitor exposure to carcinogenic benzene via environmental, occupational or lifestyle factors among pregnant women. Benzene is a well-known cause of adult leukemia. However, proof of benzene involvement with childhood leukemia remains scarce despite previously reported research linking incidences of hematological disorders and maternal benzene exposure. Furthermore, accumulating evidence has shown that maternal benzene exposure is able to alter the developmental and functional properties of HSPCs, leading to hematological disorders in fetus and children. Since HSPCs are parental blood cells that regulate hematopoiesis during the fetal and adult stages, benzene exposure that targets HSPCs may induce damage to the population and trigger the development of hematological diseases. Therefore, the mechanism of in utero carcinogenicity by benzene in targeting fetal HSPCs is the primary focus of this review.

show abstract

Section: Mechanisms Of Benzene-induced In Utero Carcinogenicity Invol...mentioning

confidence: 99%

Linking Benzene, in Utero Carcinogenicity and Fetal Hematopoietic Stem Cell Niches: A Mechanistic Review

Yusoff

Hamid

Budin

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…These enzymes include processes involving DNMTs, HDACs, histone acetylases (HATs), HMTs, and the methyl-CpG-binding protein (MeCP2). 8 Journal of South Asian Federation of Obstetrics and Gynaecology, Volume 15 Issue 1 (January-February 2023) lifestyle factors can have an impact on and alter their epigenome, DNA methylation status, and histone modifications. This is connected to the type of DNA methylation, for instance, during aging.…”

Section: Definitionmentioning

confidence: 99%

The Role of Epigenetics in Endometriosis

Widhusadi¹,

Anantasika²

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

View full text Add to dashboard Cite

Epigenetics is a field that studies that study the changing in the regulation of gene activity and expression that are independent of the DNA sequence of genes and can be inherited or inherited. This refers to a change in phenotypic status that is not based on a change in genotype. Epigenetics is known to have a part in the pathogenesis of endometriosis. Epigenetics can cause endometriosis is known through mechanisms such as DNA methylation, histone modification, and microRNA (miRNA). These various mechanisms are also related to environmental, immune, and hormonal factors that trigger endometriosis. Endometriosis is a gynecological problem involving the stroma of the endometrium and glands which normally line the uterine cavity but is found outside the uterine cavity (endometrial-like tissues). Until now, the etiopathogenesis of endometriosis is still under debate. Etiopathogenesis of endometriosis is said to be related to the genetic system and epigenetic abnormalities. Reversibility is the key to epigenetic change therefore it is used as a potential epigenetic therapy option. Enzymes that control epigenetic change are the goal of studies into pharmacological interventions in endometriosis. Therefore, the role of epigenetics requires further attention in the diagnosing, management, and prognosis of endometriosis condition so that the patient's quality of life will be better.

show abstract

“…The category of factors that influence infertility is a history of reproductive disorders where from the study data that Endometriosis and PCOS (PolyCystic Ovarian Syndrome) are associated with impaired spermatogenesis and oogenesis that can lead to infertility (Lestari SW, 2016). PCOS is a condition in which the ovaries produce abnormal amounts of androgens, male sex hormones that are usually present in women in small amounts, the name polycystic ovary syndrome describes the many small cysts (fluid-filled sacs) that form in the eggs (ovaries) (Hopkins, 2021).…”

Section: History Of Reproductive Disordersmentioning

confidence: 99%

Determinants of Male and Female Infertility: A Systematic Review

Puspitaningrum¹,

Nugraheni

2022

Jurnal Kebidanan

View full text Add to dashboard Cite

Infertility is a problem that is still a lot in the world. Infertility cases are fertility disorders in both women and men caused by reproductive disorders and environmental factors. The purpose of this study was to determine the determinants of infertility by using studies obtained from 8 national and international databases, namely Garuda portal national system, Google Scholar and Sinta, international system with Science Direct, Scopus, Cambridge Core, Proquest, Springer Link. Then processed and selected with a prism diagram. The relevant results are 10 studies through the national system and 10 studies through the international system. It was found that there are 4 categories that are the determinants of male and female infertility, including the history of reproductive disorders, prevention in infertility, Problem Solving the mental readiness of the couple and the lifestyle of the couple.

show abstract

Epigenetic: A new approach to etiology of infertility

Cited by 7 publications

References 49 publications

Linking Benzene, in Utero Carcinogenicity and Fetal Hematopoietic Stem Cell Niches: A Mechanistic Review

Linking Benzene, in Utero Carcinogenicity and Fetal Hematopoietic Stem Cell Niches: A Mechanistic Review

The Role of Epigenetics in Endometriosis

Determinants of Male and Female Infertility: A Systematic Review

Contact Info

Product

Resources

About