Epigallocatechin gallate promotes GLUT4 translocation in skeletal muscle

Ueda, Mami; Nishiumi, Shin; Nagayasu, Hironobu; Fukuda, Itsuko; Yoshida, Ken-ichi; Ashida, Hitoshi

doi:10.1016/j.bbrc.2008.09.128

Cited by 106 publications

(100 citation statements)

References 19 publications

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“…Recently, epigallocatechin, which is a major polyphenol in green tea, has been reported to decrease blood glucose levels and to increase glucose uptake through GLUT4 translocation in rat skeletal muscles (Ueda et al 2008). …”

Section: Ir Mrna Expression and Akt Phosphorylation By Fx In Soleus Amentioning

confidence: 99%

Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A mice

2012

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Fucoxanthin (Fx) isolated from Undaria pinnatifida suppresses the development of hyperglycemia and hyperinsulinemia of diabetic/obese KK-A y mice after two weeks of feeding 0.2% Fx-containing diet. In the soleus muscle of KK-A y mice that were fed Fx, glucose transporter 4 (GLUT4) translocation to plasma membranes from cytosol was promoted. On the other hand, Fx increased GLUT4 expression levels in the extensor digitorum longus (EDL) muscle, although GLUT4 translocation tended to increase. The expression levels of insulin receptor (IR) mRNA and phosphorylation of Akt, which are in upstream of the insulin signaling pathway regulating GLUT4 translocation, were also enhanced in the soleus and EDL muscles of the mice fed Fx. Furthermore, Fx induced peroxisome proliferator activated receptor  coactivator-1 (PGC-1), which has been reported to increase GLUT4 expression, in both soleus and EDL muscles. These results suggest that in diabetic/obese KK-A y mice, Fx improves hyperglycemia by activating the insulin signaling pathway, including GLUT4 translocation, and inducing GLUT4 expression in the soleus and EDL muscles, respectively, of diabetic/obese KK-A y mice.

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Section: Ir Mrna Expression and Akt Phosphorylation By Fx In Soleus Amentioning

confidence: 99%

Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A mice

2012

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“…Previous studies have shown that catechins such as EGCG promote glucose uptake in skeletal muscle by increasing glucose transporter 4 (Glut4) translocation via the AMPK or phosphatidylinositol 3-kinase (PI3K)/Akt pathway (Fig. 4) (Ueda et al, 2008;Zhang et al, 2010). A basic di-peptide, Trp-His, also has the potential to promote glucose uptake by Ca 2 þ -CaM/AMPK activation through peptide/histidine transporter 1 (PHT1) incorporation into L6 cells .…”

Section: Activity Of Theasinensins In Musclementioning

confidence: 98%

Condensed catechins and their potential health-benefits

Matsui

2015

European Journal of Pharmacology

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“…Several in vitro studies have provided evidence supporting the anti-diabetic effect of green tea catechins. It has been shown that EGCG increases glucose transporter 4 translocation in rat skeletal muscle cells 20) and suppresses gluconeogenesis in rat hepatoma cells. 21) In addition, ECG has been shown to suppress glucose absorption in the rabbit small intestine.…”

Section: )mentioning

confidence: 99%

Structure-Dependent Inhibitory Effects of Green Tea Catechins on Insulin Secretion from Pancreatic β-Cells

Kaneko

Takii

Kojima

et al. 2015

Biological & Pharmaceutical Bulletin

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The effects of green tea catechins on glucose-stimulated insulin secretion (GSIS) were investigated in the β-cell line INS-1D. Epigallocatechin gallate (EGCG) at 10 µM or gallocatechin gallate (GCG) at 30 µM caused significant inhibitory effects on GSIS, and each of these at 100 µM almost abolished it. In contrast, epicatechin (EC) or catechin (CA) had no effect on GSIS at concentrations up to 100 µM. We thus investigated the structure-activity relationship by using epigallocatechin (EGC) and gallocatechin (GC) containing a trihydroxyl group in the B-ring, and epicatechin gallate (ECG) and catechin gallate (CG) containing the gallate moiety. EGC, GC, and ECG caused an inhibition of GSIS, although significant effects were obtained only at 100 µM. At this concentration, EGC almost abolished GSIS, whereas GC and ECG partially inhibited it. In contrast, CG did not affect GSIS at concentrations up to 100 µM. EGCG also abolished the insulin secretion induced by tolbutamide, an ATP-sensitive K channel blocker, and partially inhibited that induced by 30 mM K . Moreover, EGCG, but not EC, inhibited the oscillation of intracellular Ca 2 concentration induced by 11.1 mM glucose. These results suggest that some catechins at supraphysiological concentrations have inhibitory effects on GSIS, the potency of which depends on their structure; the order of potency was EGCG>GCG>EGC>GC≈ECG. The inhibitory effects seem to be mediated by the inhibition of voltagedependent Ca 2 channels, which is caused, at least in part, by membrane hyperpolarization resulting from the activation of K channels.

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Epigallocatechin gallate promotes GLUT4 translocation in skeletal muscle

Cited by 106 publications

References 19 publications

Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A mice

Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A mice

Condensed catechins and their potential health-benefits

Structure-Dependent Inhibitory Effects of Green Tea Catechins on Insulin Secretion from Pancreatic β-Cells

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