Epigallocatechin gallate potentially abrogates fluoride induced lung oxidative stress, inflammation via Nrf2/Keap1 signaling pathway in rats: An in-vivo and in-silico study

Thangapandiyan, S.; Miltonprabu, Selvaraj; Senthilraja, P.

doi:10.1016/j.intimp.2016.07.022

Cited by 71 publications

(47 citation statements)

References 36 publications

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“…In addition, EGCG pretreatment significantly enhanced the activation of Nrf2 and its target genes HO‐1, NQO1 and γ ‐GCS, and inhibited Keap1 in the testis . One year later, they demonstrated that EGCG might also abolish FI‐induced oxidative lung injury through activating the Nrf2/Keap1 pathway in rats as well . Cumulative studies have shown that EGCG can be identified as a novel Nrf2 activator to provide strategies for the prevention and treatment of oxidative stress and inflammation‐related diseases.…”

Section: Natural Polyphenols Nrf2 Activators In Multiple Disease Modelsmentioning

confidence: 99%

“…FI-induced lung injury rats "Nrf2 nuclear translocation [51] Chem. Biodiversity 2019, 16, e1900400 www.cb.wiley.com (9 of 18) e1900400 [40] In the study by Pang et al, it is demonstrated that CA inhibited the binding of Keap1 to Nrf2 by decreasing Keap1 expression, thereby activating Nrf2 and leading to increased expression of antioxidant signals including HO-1 and NQO1 to prevent Acetaminophen (APAP)-induced hepatotoxicity.…”

Section: Caffeic Acid and Caffeic Acid Phenethyl Estermentioning

confidence: 99%

“…[50] One year later, they demonstrated that EGCG might also abolish FI-induced oxidative lung injury through activating the Nrf2/Keap1 pathway in rats as well. [51] Cumulative studies have shown that EGCG can be identified as a novel Nrf2 activator to provide strategies for the prevention and treatment of oxidative stress and inflammation-related diseases. In the clinical study, EGCG may be beneficial to intraocular retinal function in patients with early to moderate glaucoma damage, but it does not provide evidence for its long-term role.…”

Section: Other Polyphenolsmentioning

confidence: 99%

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Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Zhou

Jiang

et al. 2019

Chemistry & Biodiversity

142

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The Keap1‐Nrf2/ARE signaling pathway is an important defense system against exogenous and endogenous oxidative stress injury. The dysregulation of the signaling pathway is associated with many diseases, such as cancer, diabetes, and respiratory diseases. Over the years, a wide range of natural products has provided sufficient resources for the discovery of potential therapeutic drugs. Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1‐Nrf2 protein–protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway. In fact, with the continuous improvement of natural polyphenols separation and purification technology and further studies on the Keap1‐Nrf2 molecular mechanism, more and more natural polyphenols monomer components of Nrf2 activators have been gradually discovered. In this view, we summarize the research status of natural polyphenols that have been found with apparent Nrf2 activation and their action modes. On the whole, this review may guide the design of novel Keap1‐Nrf2 activator.

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Section: Natural Polyphenols Nrf2 Activators In Multiple Disease Modelsmentioning

confidence: 99%

Section: Caffeic Acid and Caffeic Acid Phenethyl Estermentioning

confidence: 99%

Section: Other Polyphenolsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Zhou

Jiang

et al. 2019

Chemistry & Biodiversity

142

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“…Antioxidant supplementation is known to increase the risk of lung cancer, and EGCG as an exemplary antioxidant reported to induce significant cell death and DNA damage in human lung cells through a reductive mechanism (43). KEGG pathway enrichment analysis indicated that EGCG inhibited lung cancer by affecting DNA replication, complement and coagulation cascades, cell cycle, and other signaling pathways, including the Wnt/β-catenin, unclear respirator factor2/Kelch-like ECH-associated protein 1, mitogen-activated kinase/ERK, EGFR, STAT3, and AKT signaling pathways (38,(44)(45)(46)(47). However, the precise co-regulatory functions and mechanisms of lncRNA-mRNA require further investigation.…”

Section: Discussionmentioning

confidence: 99%

Epigallocatechin‑3‑gallate modulates long non‑coding RNA and mRNA expression profiles in lung cancer cells

Guo

et al. 2019

Mol Med Report

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Epigallocatechin-3-gallate (EGCG), a major constituent of green tea, is a potential anticancer agent, but the molecular mechanisms of its effects are not well-understood. The present study was conducted to examine the mechanism of EGCG in lung cancer cells. Alterations in long non-coding RNAs (lncRNAs) and mRNAs were investigated in lung cancer cells treated with EGCG by lncRNA microarray analysis. Furthermore, the functions and signaling pathways regulated by EGCG were predicted by bioinformatics analysis. A total of 960 lncRNAs and 1,434 mRNAs were significantly altered following EGCG treatment. These lncRNAs were distributed across nearly all human chromosomes and the mRNAs were involved in the cell cycle and the mitotic cell cycle process. Through a combination of microarray and bioinformatics analysis, 20 mRNAs predicted to serve a key role in the EGCG regulation were identified, and certain regulatory networks involving EGCG-regulated lncRNAs were predicted. In conclusion, EGCG affects the expression of various lncRNAs and mRNAs in the cells, therefore affecting cell functions. The results of the present study provide an insight into the mechanism of EGCG, which may be useful for therapeutic development.

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“…Chronic toxicity of fluoride is more common than acute toxicity. Excessive intake of fluoride may result in skeletal and dental fluorosis in humans and animals (Irigoyencamacho, García, Mejía, & Huizar, 2015) and changes in the structure and function of soft tissues, including liver (Mukhopadhyay, Srivastava, & Chattopadhyay, 2015), brain (Zheng, Sun, Ke, Ouyang, & Zhang, 2016), lung (Shanmugam, Selvaraj, & Poomalai, 2016), spleen (Kuang et al, 2017), thymus (Stawiarska-Pięta et al, 2013), heart (Oyagbemi et al, 2017), intestine (Luo et al, 2013), and reproductive organs (Wei, Luo, Sun, Wang, & Wang, 2016). Also, the kidney is very sensitive to fluoride toxicity (Song et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective effects of the garlic (Allium sativum) in sodium fluoride-treated rats

Abdel-Baky

Abdel-Rahman

2020

JoBAZ

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Background: Excessive intake of fluoride may result in the development of cardiotixicity in the rats. The objective of this study was to investigate the possible cardioprotective effect of the garlic (G) on sodium fluoride (NaF)treated rats. Methods: Twenty-four male albino rats (100-120 g), 2 months old, were equally divided into control, NaF, G, and NaF + G groups. Group 1 was control group, the animals without any treatment. Group 2 was administrated with NaF orally (10 mg/kg BWT) daily. Group 3 received orally G alone (63 mg/kg BWT) daily. Group 4 was administrated with NaF + G at the same time (with the same previous doses) daily. The experimental period was for 4 weeks. Results: NaF significantly elevated the levels of serum creatinine kinase (CK), creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), Aalanine aminotransferase (ALT), and cardiac troponin I (cTnI). Also, there was a significant increase in the total cholesterol (TC), triglycerides (TAG), low-density lipoprotein (LDL-c) fractions, and the atherogenic effect (the mean ratios of TC/LDL-c and LDL-c/ (high-density lipoprotein) HDL-c), whereas a significant decrease in HDL-c occurred in the NaF-treated group compared with the control animals. The treatment with G+NaF ameliorated all the biochemical parameters tested. Conclusion: These results indicate that garlic has a cardioprotective effect against NaF cardiotoxicity.

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Epigallocatechin gallate potentially abrogates fluoride induced lung oxidative stress, inflammation via Nrf2/Keap1 signaling pathway in rats: An in-vivo and in-silico study

Cited by 71 publications

References 36 publications

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Recent Advances of Natural Polyphenols Activators for Keap1‐Nrf2 Signaling Pathway

Epigallocatechin‑3‑gallate modulates long non‑coding RNA and mRNA expression profiles in lung cancer cells

Cardioprotective effects of the garlic (Allium sativum) in sodium fluoride-treated rats

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