Epigallocatechin Gallate Attenuates Behavioral Defects in Sodium Valproate Induced Autism Rat Model

Kumaravel, P.; Melchias, G.; Vasanth, Nayagam; Manivasagam, Thamilarasan

doi:10.5958/0974-360x.2017.00260.8

Cited by 9 publications

(4 citation statements)

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“…Repetitive behaviours were also observed at the lower doses. Specifically, stereotypic self-grooming, digging, jumping, and headshakes were increased at 300-600 mg/ kg VPA (Table 1; although self-grooming and hole-poking were decreased in one study [49]). Interestingly, Jaiswal [50] showed increased self-grooming with the very low doses of 25 and 50 mg/kg VPA.…”

Section: Core Asd Behaviour 2: Repetitive Behaviours Open Field Testsmentioning

confidence: 98%

A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism

et al. 2020

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Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. Unfortunately, few pharmacological treatments exist to alleviate these socio-behavioural impairments. Prenatal administration of valproic acid (VPA) has become an accepted animal model of ASD and has been extensively used to explore new pharmacotherapies in rodents. We conducted a systematic review of the behavioural impairments induced by the VPA model in rodents, with specific reference to 3 core socio-behavioural alterations associated with ASD: repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. We systematically reviewed studies attempting to alleviate these core behavioural alterations using pharmacological means. We include 132 studies exploring the prenatal effects of VPA in rodents. Gestational exposure to VPA in rodents has significant effects on rodent-equivalent measures of the 3 core behavioural traits characteristic of ASD in humans, inducing social impairments, repetitive behaviour, and cognitive rigidity/inflexibility after birth. This model's validity has seen it used to test potential drug treatments for ASD and is likely to continue doing so. We conclude the rodent VPA model may be suitable to examine future therapeutic interventions for ASD, providing an overview of the progress made so far.

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Section: Core Asd Behaviour 2: Repetitive Behaviours Open Field Testsmentioning

confidence: 98%

A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism

et al. 2020

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“…Daily intake of green tea extract ( Camellia sinensis ), a polyphenols source, is proved to exhibit health effects ( Schimidt et al, 2017 ). This plant enhanced the locomotion activity in valproate-induced autistic mice ( Banji et al, 2011 ; Takeda et al, 2011 ; Sundberg and Sahin, 2015 ; Kumaravel et al, 2017 ; Urdaneta et al, 2018 ). Major antioxidant enzymes such as superoxide dismutase were increased by catechin, in autistic children ( Rossignol and Frye, 2014 ).…”

Section: Treatment Of Neuropsychiatric Disorders In Conventional Mean...mentioning

confidence: 97%

Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update

et al. 2022

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Neuropsychiatric diseases are a group of disorders that cause significant morbidity and disability. The symptoms of psychiatric disorders include anxiety, depression, eating disorders, autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, and conduct disorder. Various medicinal plants are frequently used as therapeutics in traditional medicine in different parts of the world. Nowadays, using medicinal plants as an

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“…The treatment of co-ultramicronized palmitoylethanolamide and the flavonoid luteolin in a murine model of autism was efficient in ameliorating social and non-social symptoms via modulation of TNFα and IL-1β immunoreactivity, reduction of GFAP, NF-κB and increased neurogenesis and neuroplasticity in the hippocampus [121]. Moreover, consumption of epigallocatechin-3-gallate, the major compound of catechin in green tea can reverse the behavioural alterations in the sodium valproate-induced autism rat model possibly due to antioxidant effects [122]. Naringenin is a flavanone abundantly found in oranges, grapefruit, and tomato skin.…”

Section: Protective Effects Of Other Flavonoids In Pediatric Neurolog...mentioning

confidence: 97%

Neuroprotective Effects of Quercetin in Pediatric Neurological Diseases

2020

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Oxidative stress is a crucial event underlying several pediatric neurological diseases, such as the central nervous system (CNS) tumors, autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). Neuroprotective therapy with natural compounds used as antioxidants has the potential to delay, ameliorate or prevent several pediatric neurological diseases. The present review provides an overview of the most recent research outcomes following quercetin treatment for CNS tumors, ASD and ADHD as well as describes the potential in vitro and in vivo ameliorative effect on oxidative stress of bioactive natural compounds, which seems like a promising future therapy for these diseases. The neuroprotective effects of quercetin against oxidative stress can also be applied in the management of several neurodegenerative disorders with effects such as anti-cancer, anti-inflammatory, anti-viral, anti-obesity and anti-microbial. Therefore, quercetin appears to be a suitable adjuvant for therapy against pediatric neurological diseases.

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Epigallocatechin Gallate Attenuates Behavioral Defects in Sodium Valproate Induced Autism Rat Model

Cited by 9 publications

References 0 publications

A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism

A Systematic Review of the Valproic-Acid-Induced Rodent Model of Autism

Pharmacological effects and therapeutic potential of natural compounds in neuropsychiatric disorders: An update

Neuroprotective Effects of Quercetin in Pediatric Neurological Diseases

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