Neuroprotective Effects of Quercetin in Pediatric Neurological Diseases

Álvarez-Arellano, Lourdes; Salazar–García, Marcela; Corona, Juan Carlos

doi:10.3390/molecules25235597

Cited by 24 publications

(20 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ROS induce protein oxidation (Salehi et al, 2019a), lipid peroxidation (Salehi et al, 2019c), and neurons and glial cells leading to the death of neurons (Gilgun-Sherki et al, 2001). Moreover, aging established neuronal damage mediated by ROS cause neurodegeneration (Uttara et al, 2009;Alvarez-Arellano et al, 2020).…”

Section: Quercetin Against Oxidative Stressmentioning

confidence: 99%

Neuropharmacological Effects of Quercetin: A Literature-Based Review

et al. 2021

View full text Add to dashboard Cite

Quercetin (QUR) is a natural bioactive flavonoid that has been lately very studied for its beneficial properties in many pathologies. Its neuroprotective effects have been demonstrated in many in vitro studies, as well as in vivo animal experiments and human trials. QUR protects the organism against neurotoxic chemicals and also can prevent the evolution and development of neuronal injury and neurodegeneration. The present work aimed to summarize the literature about the neuroprotective effect of QUR using known database sources. Besides, this review focuses on the assessment of the potential utilization of QUR as a complementary or alternative medicine for preventing and treating neurodegenerative diseases. An up-to-date search was conducted in PubMed, Science Direct and Google Scholar for published work dealing with the neuroprotective effects of QUR against neurotoxic chemicals or in neuronal injury, and in the treatment of neurodegenerative diseases. Findings suggest that QUR possess neuropharmacological protective effects in neurodegenerative brain disorders such as Alzheimer’s disease, Amyloid β peptide, Parkinson’s disease, Huntington's disease, multiple sclerosis, and amyotrophic lateral sclerosis. In summary, this review emphasizes the neuroprotective effects of QUR and its advantages in being used in complementary medicine for the prevention and treatment o of different neurodegenerative diseases.

show abstract

Section: Quercetin Against Oxidative Stressmentioning

confidence: 99%

Neuropharmacological Effects of Quercetin: A Literature-Based Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Flavonoids belong to a large group of natural polyphenolic phytochemicals with several subclasses and have shown beneficial effects, such as antioxidantantioxidant activity in several neurodegenerative and neuropsychiatric disorders, as well as anti-inflammatory, anti-obesity, anti-diabetic, and cardioprotective activity. Quercetin is a flavonoid com-pound present in a wide variety of fruits and vegetables and has been shown to exert therapeutic effects [100]. The oral administration of quercetin to STZ-induced diabetic rats resulted in a decrease in blood glucose, plasma TBARS, and hydroperoxides levels.…”

Section: Flavonoidsmentioning

confidence: 99%

The Use of Natural Compounds as a Strategy to Counteract Oxidative Stress in Animal Models of Diabetes Mellitus

Salazar–García

Corona

2021

IJMS

Self Cite

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a chronic metabolic disease characterised by insulin deficiency, resulting in hyperglycaemia, a characteristic symptom of type 2 diabetes mellitus (DM2). DM substantially affects numerous metabolic pathways, resulting in β-cell dysfunction, insulin resistance, abnormal blood glucose levels, impaired lipid metabolism, inflammatory processes, and excessive oxidative stress. Oxidative stress can affect the body’s normal physiological function and cause numerous cellular and molecular changes, such as mitochondrial dysfunction. Animal models are useful for exploring the cellular and molecular mechanisms of DM and improving novel therapeutics for their safe use in human beings. Due to their health benefits, there is significant interest in a wide range of natural compounds that can act as naturally occurring anti-diabetic compounds. Due to rodent models’ relatively similar physiology to humans and ease of handling and housing, they are widely used as pre-clinical models for studying several metabolic disorders. In this review, we analyse the currently available rodent animal models of DM and their advantages and disadvantages and highlight the potential anti-oxidative effects of natural compounds and their mechanisms of action.

show abstract

“…Miq., Coriandrum sativum L. and Capparis spinosa L. It is one of the most consumed flavonoids in people's daily diet (Alvarez-Arellano et al, 2020). Quercetin has a variety of biological activities, such as antioxidant and scavenging free radicals (Wang et al, 2021e), anti-cancer, anti-aging (Zhu et al, 2015), anti-inflammatory (Rauf et al, 2018;Cui et al, 2019) anti-virus and immune regulation (Zhu et al, 2015;Alvarez-Arellano et al, 2020). It has a very important clinical significance in the treatment of bacterial infection, viral infection, hyperlipidemia and immune system diseases, especially for those caused by increased oxidative stress Cell damage and even mitochondrial dysfunction related diseases have potential protein synthesis (Nagata et al, 2004).…”

Section: Quercetinmentioning

confidence: 99%

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Pang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocyte specific antigen exposure as well as melanocyte cell death and thus serves as an important contributor for vitiligo progression. In recent years, natural products have shown a wide range of pharmacological bioactivities against many skin diseases, and this review focuses on the effects and mechanisms of natural compounds against vitiligo models. It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/β-catenin signaling pathways were reported to be implicated in these protective effects. This review discusses the great potential of plant derived natural products as anti-vitiligo agents, as well as the future directions to explore.

show abstract

Neuroprotective Effects of Quercetin in Pediatric Neurological Diseases

Cited by 24 publications

References 128 publications

Neuropharmacological Effects of Quercetin: A Literature-Based Review

Neuropharmacological Effects of Quercetin: A Literature-Based Review

The Use of Natural Compounds as a Strategy to Counteract Oxidative Stress in Animal Models of Diabetes Mellitus

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Contact Info

Product

Resources

About