(−)−Epigallocatechin‐3‐gallate Inhibits Pancreatic Lipase and Reduces Body Weight Gain in High Fat‐Fed Obese Mice

Grove, Kimberly A.; Sae-tan, Sudathip; Kennett, Mary J.; Lambert, Joshua D.

doi:10.1038/oby.2011.139

Cited by 104 publications

(67 citation statements)

References 15 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This does not exclude the possibility that other lipases, including hormone-sensitive lipase and endothelial lipase, may contribute to reduction of lipid accumulation. In fact, EGCG stimulates hormone-sensitive lipase in adipocytes and pancreatic lipases in the serum that are associated with weight loss in adipose tissue (64,65). In contrast, our data present for the first time that EGCG reduces endothelial ectopic lipid accumulation.…”

Section: Discussioncontrasting

confidence: 53%

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

Kim

Montana

Jang

et al. 2013

Journal of Biological Chemistry

162

128

View full text Add to dashboard Cite

Background: Green tea polyphenol (EGCG) has beneficial effects on cardiovascular dysfunction. Results: EGCG stimulates autophagy through a CaMKK␤-mediated mechanism, which contributes to degradation of lipid droplets. Conclusion: Regulation of autophagic flux by EGCG plays a role in intracellular lipid accumulation. Significance: Findings show a novel mechanism for beneficial effects of EGCG in cardiovascular complications.

show abstract

Section: Discussioncontrasting

confidence: 53%

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

Kim

Montana

Jang

et al. 2013

Journal of Biological Chemistry

162

128

View full text Add to dashboard Cite

show abstract

“…The hypolipidemic effect of GTCs consumption is attributed to reduced intestinal absorption and decreased digestibility of cholesterol and dietary fats [52][53][54]. Additionally, EGCG has been identified to possess the potential to inhibit pancreatic lipase, contributing to the development of natural lipase inhibitors to prevent human obesity and dyslipidemia [55]. In particular, significant LDL-C reduction [9,10,13,15] is a remarkable finding, as LDL-C promotes chronic inflammation of arterial blood vessels by white blood cells [56].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials

et al. 2016

View full text Add to dashboard Cite

Green tea catechins (GTCs) are secondary plant metabolites that have been associated with health benefits in human trials. As such, they have the potential to reduce cardiovascular disease (CVD) risk; however, results are not consistent. This systematic review of the published data assessed the putative effect of GTCs supplementation on anthropometric, blood pressure, and biochemical measures associated with CVD risk. It was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines exploring four major electronic databases (MEDLINE, Cochrane Library, Web of Science, and Scopus). Studies were included if they were published in peer-reviewed journals in English from 1990 until October 2015, and were human double-blind randomized and placebo-controlled trials (RCTs). From 122,428 articles initially identified, after two levels of screening, seven studies met the inclusion criteria. The review revealed consistent and significant (p ď 0.05) reductions in body mass index (BMI), blood pressure and plasma lipids; however, this effect would have been less if between-group effects had been considered. The current evidence base also has considerable methodological limitations due to suboptimal statistical methods used in data analyses. Future research efforts must aim to rectify this paucity of evidence with well-designed and well-reported prospective studies.

show abstract

“…The reaction was incubated at room temperature for 6 min and analyzed at 400 nm. The maximum velocity (V max ) and the Michaelis-Menten constant (K m ) were determined by plotting the initial velocity data against each concentration of 4-NPB (Grove et al, 2012).…”

Section: Measurement Of the Inhibition Of The Activation Of Porcine Plmentioning

confidence: 99%

Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling

Guo

Gao

Zhang

et al. 2015

Pharmaceutical Biology

View full text Add to dashboard Cite

(2016) Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling, Pharmaceutical Biology, 54:8, 1312-1325, DOI: 10.3109/13880209.2015 Objective: The objective of this study is to investigate the antiobesity and lipid-lowering effects of sea cucumber extracts in in vitro and in vivo models and elucidate the mechanism of action of the extracts on obesity and dyslipidemia. Materials and methods: The 60% ethanol extracts from the body walls of 10 different sea cucumbers were investigated for the inhibition of pancreatic lipase (PL) activity in vitro. The optimal active extract (SC-3) was further chemically analyzed by LC-MS and UV. And 0.1% and 0.2% of SC-3 was mixed with a high-fat diet to treat C57/BL6 mice for 6 weeks or 2 weeks as preventive and therapeutic study. The body weight, serum, and liver lipid profile in the mice were investigated. Results: The crude extract of Pearsonothuria graeffei Semper (Holothuriidae) inhibited the PL activity by 36.44% of control at 0.5 mg/mL. SC-3 and echinoside A inhibited PL with an IC 50 value at 2.86 mg/ mL and 0.76 mM. 0.1% of SC-3 reduced the body weight (23.0 ± 0.62 versus 26.3 ± 0.76 g), the serum TC (2.46 ± 0.04 versus 2.83 ± 0.12 mmol/L), TG (0.19 ± 0.08 versus 0.40 ± 0.03 mmo/L), and LDL-c (0.48 ± 0.02 versus 0.51 ± 0.02 mmol/L), and liver TC (1.19 ± 0.17 versus 1.85 ± 0.13 mmol/mg) and TG (6.18 ± 0.92 versus 10.87 ± 0.97 mmol/mg) contents of the obese C57BL/six mice on a high-fat diet. Discussion and conclusion: Sea cucumber may be used for developing antiobesity and antihyperlipidemia drugs. ARTICLE HISTORY

show abstract

(−)−Epigallocatechin‐3‐gallate Inhibits Pancreatic Lipase and Reduces Body Weight Gain in High Fat‐Fed Obese Mice

Cited by 104 publications

References 15 publications

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

The Effect of Dietary Supplementation of Green Tea Catechins on Cardiovascular Disease Risk Markers in Humans: A Systematic Review of Clinical Trials

Saponin-enriched sea cucumber extracts exhibit an antiobesity effect through inhibition of pancreatic lipase activity and upregulation of LXR-β signaling

Contact Info

Product

Resources

About