Epidural Lidocaine, Nalbuphine, and Lidocaine–Nalbuphine Combination in Donkeys

Torad, Faisal A.; Hassan, Elham A.

doi:10.1016/j.jevs.2015.11.002

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…However, due to its contraindication with use time, morphine has certain limitations. Nalbuphine is short for nalbuphine hydrochloride injection, and is an opioid receptor agonist-antagonistic analgesic (22). It mainly acts on spinal cord kappa receptors, activates kappa receptors at the spinal cord level and kappa 3 receptors at the upper spinal cord, and is mainly used as relief to severe pain, such as burns, cancer, surgery, kidney, or biliary colic pain (23).…”

Section: An Animal Model That Combines Disease and Syndrome Ismentioning

confidence: 99%

Effects of dezocine, morphine and nalbuphine on electropain threshold, temperature pain threshold and cardiac function in rats with myocardial ischemia

Dong¹,

Liang²,

Xu³

et al. 2020

Ann Palliat Med

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Background: Myocardial ischemia (MI) could cause many complications, such as arrhythmia, ischemic cardiomyopathy, which could lead to angina and myocardial infarction. The clinical efficacy of dezocine, morphine and nalbuphine are becoming dominated in China market. This aim of this study was to investigate the effects of dezocine, morphine and nalbuphine on electrical pain threshold, temperature pain threshold and cardiac function in rats with MI.Methods: A rat model of MI was established by ligating the coronary artery. Rats in the model group were injected with dezocine, morphine, nalbuphine and 0.9% normal saline. The effects of the three analgesics on MI rats were evaluated by comparing the electrical pain threshold, temperature pain threshold, and cardiac function index. Results:The electrocardiogram revealed that the model of MI was successful. The results of the electrical pain threshold and temperature pain threshold tests revealed that nalbuphine was the most sensitive after medication, followed by dezocine, and the sensitivity of morphine was the lowest. These three drugs reached its peak at two hours after administration. The analgesic effect of dezocine on electrical stimulation was the best, while nalbuphine had the best effect on temperature. The efficacy of dezocine decreased with time, while morphine basically failed at four hours after administration. The peak time of these three kinds of analgesics was selected to detect the cardiac function index in each group. Morphine had the least influence on the cardiac function index of rats, followed by nalbuphine and dezocine.Conclusions: These results show that the analgesic effect of nalbuphine had the earliest and best effect with the longest duration on temperature, and had less influence and higher safety in the cardiac function test of MI rats. Hence, nalbuphine is a relatively good analgesic for MI patients. The present study provides a database for the selection of analgesics in patients with MI.

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Section: An Animal Model That Combines Disease and Syndrome Ismentioning

confidence: 99%

Effects of dezocine, morphine and nalbuphine on electropain threshold, temperature pain threshold and cardiac function in rats with myocardial ischemia

Dong¹,

Liang²,

Xu³

et al. 2020

Ann Palliat Med

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show abstract

“…They found that epidural combination of tramadol and lidocaine (0.5 mg/kg and 0.2 mg/kg, respectively) produced an antinociceptive effect in the perineum, which was rapid in onset (within 6 minutes) and had a longer duration of action (180 minutes) than lidocaine alone (duration of 75 minutes). Torad and Hassan 39 found the combination of nalbuphine and lidocaine (at dosages of 0.2 and 0.11 mg/kg, respectively) to lead to rapid onset (6.7 minutes) and long duration (147 minutes) of epidural anesthesia in donkeys. Hamed and colleagues 40 described the sedative and analgesic effects of epidural dexmedetomidine and xylazine in donkeys.…”

Section: Epidural Anesthesiamentioning

confidence: 99%

Anesthesia, Sedation, and Pain Management of Donkeys and Mules

Matthews¹,

Loon

2019

Veterinary Clinics of North America: Equine Practice

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Epidural Lidocaine, Nalbuphine, and Lidocaine–Nalbuphine Combination in Donkeys

Cited by 2 publications

References 25 publications

Effects of dezocine, morphine and nalbuphine on electropain threshold, temperature pain threshold and cardiac function in rats with myocardial ischemia

Effects of dezocine, morphine and nalbuphine on electropain threshold, temperature pain threshold and cardiac function in rats with myocardial ischemia

Anesthesia, Sedation, and Pain Management of Donkeys and Mules

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