Epidural abscess caused by community-associated methicillin-resistant Staphylococcus aureus strain USA300 in Japan

Dissemination of multiple MRSA clones among community-associated methicillin-resistant Staphylococcus aureus infections from Japanese children with impetigo

“…Because many MRSA strains isolated from healthy children carried the et gene, the possibility of carriage of the et gene in Japanese CA-MRSA seemed to be high. At the same time, we have noticed that some representative pandemic strains were also identified in Japan as minor cases, e.g., a USA 300 clone, suggesting that MRSA disseminates from person to person by contact [35,36] (Ito unpublished observation). Two kinds of CA-MRSA clones, one originating from Japanese MSSA and the other from other countries, may disseminate in the Japanese community.…”

Clinical Aspects of Infection with Methicillin-Resistant <i>Staphylococcus aureus</i> USA300 Strain, Generally Regarded as Community-Acquired, in Japan

“…Most isolates suspected as CA-MRSA were PVL-negative and did not contain the USA300 clone (16). To the best of our knowledge, only 5 cases of USA300 infection have been reported in Japan from 2007 to 2009 (17)(18)(19)(20)(21). According to these Japanese reports, CA-MRSA infection with the USA300 clone is presumed to be very rare.…”

“…The first case was a 3-month-old girl who was born in the USA and subsequently moved to Japan (18). Another case was an American woman who came from the USA to the US navy stationed in Japan (19). These cases were presumed to be imported cases of the USA300 clone.…”

Methicillin-resistant Staphylococcus-aureus-associated glomerulonephritis on the decline: decreased incidence since the 1990s

“…Moreover, the status of MRSA infection turned from HA-MRSA to CA-MRSA in the 2000s, indicating that the quality of MRSA changed drastically. The most common manifestations of CA-MRSA (in general, USA300 clone) are skin and soft tissue infections, although purpura fulminans, pyomyositis, osteomyelitis, and necrotizing pneumonia can occur [8,10,11]. USA300 clone is famous for producing a virulence factor, Panton-Valentine leukocidin, but not superantigens [8,[10][11][12].…”

“…The most common manifestations of CA-MRSA (in general, USA300 clone) are skin and soft tissue infections, although purpura fulminans, pyomyositis, osteomyelitis, and necrotizing pneumonia can occur [8,10,11]. USA300 clone is famous for producing a virulence factor, Panton-Valentine leukocidin, but not superantigens [8,[10][11][12]. According to limited information from Japan, the CA-MRSA strain in Japan produces no typical superantigens [10,12,13].…”