“…Urine antigen - negative Treated with itraconazole for 6 months | Deceased due to unknown cause of massive upper genitourinary bleeding 6 months later | Kahn et al*, 1992 (presented at VIII international conference on aids/iii std world congress, amsterdam, july 19–24, 1992; 8: 93) [ 11 ] | USA | 35 | Swelling of left testis and left cheek ulcer | Not informed | Biopsy specimen from orchiectomy positive for H. capsulatum | Not informed | Not informed | Not informed |
Plazola-Hernández et al, 2020 [ 19 ] | Mexico | 22 | Solid adherent mass in posterosuperior region of the left testis | Not informed | 5 x 5 × 2.5 cm left testis and a 3.5 x 2 × 2 cm nodule, with a dark brown, irregular surface of rubbery consistency. Histopathology: fungal structures suggestive of H. capsulatum | Not performed | Left testis simple orchiectomy | Not informed |
Botero-García et al, 2017 [ 20 ] | Colombia | 38 | Left testicular pain, swelling, erythema and fever for 1 month | Previously healthy | histopathological analysis: Hematoxylin & eosin and PAS staining showed necrotizing granulomatous epididymo-orchitis with small (2–4 μm) oval buds | Positive sperm culture for H. capsulatum; positive molecular characterization | Left orchiectomy +200 mg itraconazole every 12 h for 6 months | Improved |
Sanha et al, 2022 [present paper] | Brazil | 66 | Enlarged and hardened right testis | AIDS | Histopathological examination of testicular liquid under GMS stain: Presence of budding yeasts compatible with Histoplasma sp. | Not performed | Right orchiecromy | Deceased |
Legend: BAL, Bronchoalveolar Lavage; CF, Complement Fixation; EIA; Enzyme immunoassay; GMS, Grocot-Gomori methenamine silver; PAS, Periodic Acid-Schiff.…”