Epidermolysis Bullosa Nevus

Nevo da epidermólise bolhosa: caso clínico e revisão da literatura

“…2 The histopathological pattern of the EB nevus A B may be compatible with a compound/ junctional nevus, or a persistent nevus. [1][2][3][4][5][6] The first pattern was described in three EBS cases in the literature, and was also observed in the case here described. 1,4,5 The persistent nevus pattern is more frequent in recessive dystrophic EB patients.…”

“…It has marked asymmetry, pigmentation variation, cicatricial areas and regression focuses. 1,[3][4][5][6] Such characteristics suggest a false impression of malignancy, reinforced when the pigmented lesion shows continuous and sometimes sudden growth, with onset of satellite lesions, as occurred in our patient. 2 The EB nevus has a dynamic evolution, with fast growth and possible changes on its surface.…”

“…It is characterized by cutaneous fragility and bullous lesions that appear as result of trivial traumas. [1][2][3][4][5] Uncommon large and eruptive melanocytic nevi have been described in EB patients. [1][2][3][4][5][6] Their similarity with melanoma easily induces to diagnostic error.…”

“…1 Cash and collaborators described another patient who had dystrophic EB and an EB nevus that lost pigmentation after 18 months of follow-up. 4 Considering that morphological alterations in pigmented lesions are described as significant predictors of malignancy, it was suggested that the EB nevus could be an exception to this rule, since continuous clinical modifications of these nevi have been documented for 25 years, and cutaneous melanoma was excluded through repeated histological evaluation. 1,2,7 Lanschuetzer and collaborators analyzed the dermoscopic characteristics of 23 EB nevus lesions in 11 patients.…”

“…1 Despite its benign course, this nevus is particularly important for being clinically indistinguishable from melanoma, according to the ABCD rule. [1][2][3][4][5][6] As it simulates melanoma, this may induce to unnecessary aggressive treatment.…”