Clinicopathologic Correlation in Melanocytic Lesions

Basko-Plluska, Juliana; Prieto, Víctor G.; Reed, Jon A.; Shea, Christopher R.

doi:10.1007/978-1-4939-1444-9_3

Cited by 1 publication

(1 citation statement)

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“…Differential diagnosis of Spitz lesions can be divided into diagnoses of melanocytic lesions and non-melanocytic lesions. Common characteristics shared between SN and other melanocytic lesions are maturation, symmetry, sharp-circumscription, and regular distribution of melanocytes individually or in nests ( 18 , 35 , 49 , 50 ). Other lesions displaying epithelioid or spindle cell morphology are also on the differential, one example being epithelioid fibrous histocytoma which also features abundant eosinophilic cytoplasm and scattered mitotic figures ( 51 ).…”

Section: Clinical Featuresmentioning

confidence: 99%

The Spectrum of Spitz Melanocytic Lesions: From Morphologic Diagnosis to Molecular Classification

2022

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Spitz tumors represent a distinct subtype of melanocytic lesions with characteristic histopathologic features, some of which are overlapping with melanoma. More common in the pediatric and younger population, they can be clinically suspected by recognizing specific patterns on dermatoscopic examination, and several subtypes have been described. We now classify these lesions into benign Spitz nevi, intermediate lesions identified as “atypical Spitz tumors” (or Spitz melanocytoma) and malignant Spitz melanoma. More recently a large body of work has uncovered the molecular underpinning of Spitz tumors, including mutations in the HRAS gene and several gene fusions involving several protein kinases. Here we present an overarching view of our current knowledge and understanding of Spitz tumors, detailing clinical, histopathological and molecular features characteristic of these lesions.

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Section: Clinical Featuresmentioning

confidence: 99%