Epidermoid carcinoma arising in chronic lymphedema

Squamous cell carcinoma arising from chronic lymphedema: case report and review of the literature

“…Among the additional dermatological risk factors (seen in 50% of the cases) for the development of squamous cell carcinoma are angiosarcoma, vulgar wart, chronic verrucous hyperplasia, wart-like epidermodysplasia, generalized vitiligo, dystrophic bullous epidermolysis and ultraviolet B (UVB) therapy ( Table 1). Like in other cases reported in the literature, [1][2][3]6,8 no other additional factor was noticed in our case. Some theories attempting to explain a putative mechanism have been put forward.…”

“…[1][2][3][4][5][6][7][8][9][10] There has been little discussion and emphasis on the epidemiological characteristics and carcinogenetic predisposition of chronic lymphadema. [1][2][3] Tumor development in areas of chronic lymphedema is believed not to happen serendipitously, 1,2 and inherited susceptibility to carcinogenic stimuli 4,5 is thought to play a role. Knowledge about predisposing dermatological conditions and epidemiological features is very important, in order to diagnose the disease at an early stage.…”

Metastatic and Synchronous Melanoma in the Testicle and Paratesticular Region

“…Moreover, It is also believed that the chronic stasis secondary to congenital or surgical acquired lymphedema, produce local changes in the lymphatic protein composition (decreased alpha-2 globulin fraction and increased albumin-globulin ratio), and delaying protein transport from the interstitial space into the lymphatic tissue, might change the tissular antigenic composition and/or regional immunological competence, allowing the growth of tumors. These evidences may explain, at least in part, the development of metastastic disease in the scrotum area [6,7].…”

Postamputation diagnosis of squamous cell carcinoma in a patient with lymphedema

“…To date, 11 cases of SCC of a lower extremity affected by lymphedema have been reported ( Table ). 4 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 A congenital etiology of lymphedema was most common (36%), followed by post-traumatic (27%) and postfilarial (18%). The majority of these cases (64%) were treated with local excision with or without skin grafting of the defect.…”

“…The majority of these cases (64%) were treated with local excision with or without skin grafting of the defect. 4 , 16 , 17 , 18 , 19 , 20 Pedal amputation was required in a case of SCC in a patient with lymphedema and underlying epidermodysplasia verruciformis, with extensive involvement of the distal foot. 21 Above-the-knee amputation was required in a case of postfilarial lymphedema and SCC presenting with multiple ulcerations and wet gangrene who had been nonambulatory before presentation, 15 as well as in a case of nonhealing ulcers of the foot with long-standing lymphedema nonresponsive to multiple treatments.…”