Postamputation diagnosis of squamous cell carcinoma in a patient with lymphedema

Squamous cell carcinoma arising in a below-knee stump of a patient with chronic lymphocytic leukemia

“…5 Recently, invasive squamous cell carcinoma in a patient with leg ulceration secondary to lymphedema was reported on histopathological examination of the ulcer in the amputated stump. 6 Rapid development of invasive squamous cell carcinoma was also recently reported at the donor site for a split-thickness skin graft in setting of severe burn just 2 weeks after excision 7…”

Squamous cell carcinoma of skin in a case of post-filariasis chronic lower limb lymphedema- a case study and review of literature

“…Above knee amputation was required in another case of non-healing ulcers of the foot with long-standing congenital lymphedema nonresponsive to multiple treatments [ 11 ]. Below knee amputation was done in one case of lymphedema praecox with full-thickness ulceration of the dorsal aspect of her ankle as despite aggressive wound care, negative pressure therapy, as well as surgical debridement and skin grafting wound didn't heal [ 18 ].Pedal amputation was required in a case of SCC in a patient with lymphedema and underlying epidermodysplasia verruciformis, with extensive involvement of the distal foot [ 19 ]. The role of adjuvant radiotherapy was only described in one case for regional lymph nodal metastasis but there is no documentation of role of chemotherapy and immunotherapy in the literature.…”