Epidermodysplasia verruciformis (L-L, 1922) in a patient with systemic lupus erythematosus

Tanigaki, Takehiko; Kanda, Ryoji; Sato, Katsuaki

doi:10.1007/bf00412934

Cited by 22 publications

(21 citation statements)

References 4 publications

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“…In patients with such a genetic predisposition and a mutation in the EVER1 or EVER2 genes, numerous cutaneous warts develop, and on sun-exposed sites a high rate of transformation to squamous cell carcinomas is well-documented. However, other risk factors for EV exist besides UV exposure, such as immunosuppression in HIV-positive patients, lymphoma and graft-versus-host disease [21,22,23]. Although EV-like lesions in those patients who are immunocompromised are rare, this phenotype may be linked to EV-related haplotypes.…”

Section: Discussionmentioning

confidence: 99%

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Epidermodysplasia Verruciformis in a HIV-Positive Patient Homozygous for the c917A→T Polymorphism in the <i>TMC8/EVER2 </i>Gene

Hohenstein¹,

Rády²,

Hergersberg³

et al. 2008

Dermatology

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Background: Epidermodysplasia verruciformis (EV) is a rare autosomal-recessive disorder characterized by widespread and persistent infection with human papilloma virus (HPV) and a risk of malignant degeneration. Most cases of EV are caused by mutations in the two EV genes, EVER1/TMC6 and EVER2/TMC8. The clinical presentation of EV takes two different forms, which coexist in most cases. Over a period of years, patients develop plane warts and pityriasis versicolor-like lesions. Sixteen cases of EV in HIV-positive patients have been clinically investigated and reported in the literature. However, different inherited susceptibilities towards HPV infection in immunodeficient patients, like HIV-positive patients, have only rarely been addressed. Observation: We describe a 22-year-old female patient with a congenital HIV infection, who presented with slowly progressing and confluent erythematous papules on her hands and hypopigmented macules on her extremities. The histopathology was typical for EV, and HPV5 was detected by PCR and reverse hybridization. The 44-year-old HIV-positive mother has no typical EV lesions. The patient is homozygous for an A to T single nucleotide polymorphism (SNP) at position 917 of the TMC8/EVER2 gene. The mother of the patient is heterozygous for this SNP. Conclusion: These results support the hypothesis that the combination of immunodeficiency and a susceptibility allele may contribute to the differences in occurrence of EV in HIV-positive patients.

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Section: Discussionmentioning

confidence: 99%

“…In addition, patients with immunodeficiency states, e.g. following renal transplantation, in systemic lupus erythematosus or Hodgkin’s disease, have developed EV-like skin lesions [21,22,23]. It is well known that in immunosuppressed individuals the HPV infection rate is increased [24].…”

Section: Introductionmentioning

confidence: 99%

Epidermodysplasia Verruciformis in a HIV-Positive Patient Homozygous for the c917A→T Polymorphism in the <i>TMC8/EVER2 </i>Gene

Hohenstein¹,

Rády²,

Hergersberg³

et al. 2008

Dermatology

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“…Although in most cases clinical and histological features of the warts [17,42,43,46,47,48] and the associated HPV types [17,46,48] in immunosuppressed patients do not differ from those in the general population, rare cases of acquired EV-like eruption have been reported in immunosuppressed patients, including patients with organ transplants [15,16,17,18,19], lepromatous leprosy [49], Hodgkin lymphoma [20], systemic lupus erythematosus [21,22], human immunodeficiency virus infection [19,23,24,25,26,27,28,29,30,31,32,33,34,50,51], severe combined immune deficiency caused by γc or JAK3 deficiency after hemopoietic stem cell transplantation [35], and in the setting of graft-versus-host disease [36]. Treatment with biological agents may also increase the risk for HPV infections including acquired EV [52].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, β-papillomaviruses may be commensals of the human skin and harmless for the general population, although their roles in the development of nonmelanoma skin cancers, particularly in immunosuppressed patients, have been suggested [12,13,14]. In addition, acquired EV-like eruption associated with β-papillomavirus infection has occasionally been described in immunosuppressed patients [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36]. …”

Section: Introductionmentioning

confidence: 99%

Epidermodysplasia-Verruciformis-Like Eruption Associated with Gamma-Papillomavirus Infection in a Patient with Adult T-Cell Leukemia

Kawai

Egawa²,

Kiyono³

et al. 2009

Dermatology

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Epidermodysplasia verruciformis (EV) is a genodermatosis characterized by widespread and persistent cutaneous lesions caused by β-papillomaviruses. Rare cases of acquired EV-like eruption associated with β-papillomavirus infection have been reported in immunosuppressed patients. We report a case of acquired EV-like eruption in an immunosuppressed patient with adult T-cell leukemia. The cutaneous lesions clinically resembled pityriasis versicolor and exhibited the typical histological features of EV, but in some areas of the same biopsy specimen characteristic homogeneous intracytoplasmic inclusion bodies were observed. Although β-papillomavirus was not detected by highly sensitive polymerase chain reaction, a putative novel type of γ-papillomavirus was identified. This is the first documentation of an association between EV-like eruption and γ-papillomavirus infection.

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“…There is an indication of EV-like disease being a result of exogenous immunodeficiency in HIV infection and in the patients with immunodeficiency states(e.g. following renal transplantation, in systemic lupus erythematosus or Hodgkin's disease ) [21][22][23][24].This form has been named "acquired epidermodysplasia verruciformis" [25].…”

Section: Clinical and Histologic Findingsmentioning

confidence: 99%

Genetics of Epidermodysplasia Verruciformis

Kawase¹

2013

Current Genetics in Dermatology

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Epidermodysplasia verruciformis (L-L, 1922) in a patient with systemic lupus erythematosus

Cited by 22 publications

References 4 publications

Epidermodysplasia Verruciformis in a HIV-Positive Patient Homozygous for the c917A→T Polymorphism in the <i>TMC8/EVER2 </i>Gene

Epidermodysplasia Verruciformis in a HIV-Positive Patient Homozygous for the c917A→T Polymorphism in the <i>TMC8/EVER2 </i>Gene

Epidermodysplasia-Verruciformis-Like Eruption Associated with Gamma-Papillomavirus Infection in a Patient with Adult T-Cell Leukemia

Genetics of Epidermodysplasia Verruciformis

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