Epidermal Wearable Biosensors for Monitoring Biomarkers of Chronic Disease in Sweat

Yuan, Xiaohui; Li, Chen; Yin, Xu; Yang, Yang; Ji, Bowen; Niu, Youguo; Ren, Li

doi:10.3390/bios13030313

Cited by 16 publications

(13 citation statements)

References 190 publications

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“…Paper-based sensors have numerous capillaries, which can quickly collect and transfer sweat [68,69]. Thread exhibits superior toughness compared to paperbased materials, enabling it to endure higher levels of stress without breaking [79,216,217].…”

Section: Discussionmentioning

confidence: 99%

“…The thread is formed by wrapping multiple strands of fine wire, and the gaps between the wrapped threads can serve as capillary channels for fluid transport [79]. Compared with paper-based materials, threads have stronger toughness and can be easily obtained from natural or artificial materials.…”

Section: Thread-based Sampling Of Non-electrochemical Sweat Sensorsmentioning

confidence: 99%

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Advances in Non-Electrochemical Sensing of Human Sweat Biomarkers: From Sweat Sampling to Signal Reading

Yang,

Sun,

Lai

et al. 2023

Biosensors

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Sweat, commonly referred to as the ultrafiltrate of blood plasma, is an essential physiological fluid in the human body. It contains a wide range of metabolites, electrolytes, and other biologically significant markers that are closely linked to human health. Compared to other bodily fluids, such as blood, sweat offers distinct advantages in terms of ease of collection and non-invasive detection. In recent years, considerable attention has been focused on wearable sweat sensors due to their potential for continuous monitoring of biomarkers. Electrochemical methods have been extensively used for in situ sweat biomarker analysis, as thoroughly reviewed by various researchers. This comprehensive review aims to provide an overview of recent advances in non-electrochemical methods for analyzing sweat, including colorimetric methods, fluorescence techniques, surface-enhanced Raman spectroscopy, and more. The review covers multiple aspects of non-electrochemical sweat analysis, encompassing sweat sampling methodologies, detection techniques, signal processing, and diverse applications. Furthermore, it highlights the current bottlenecks and challenges faced by non-electrochemical sensors, such as limitations and interference issues. Finally, the review concludes by offering insights into the prospects for non-electrochemical sensing technologies. By providing a valuable reference and inspiring researchers engaged in the field of sweat sensor development, this paper aspires to foster the creation of innovative and practical advancements in this domain.

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Section: Discussionmentioning

confidence: 99%

Section: Thread-based Sampling Of Non-electrochemical Sweat Sensorsmentioning

confidence: 99%

Advances in Non-Electrochemical Sensing of Human Sweat Biomarkers: From Sweat Sampling to Signal Reading

Yang,

Sun,

Lai

et al. 2023

Biosensors

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“…This is an ambitious goal that can be achieved by using appropriate biosensors that should be designed accordingly. Biosensors are innovative tools that combine biological recognition elements with transducing components to detect and quantify specific molecules within complex samples ( Yuan et al, 2023 ). The development of biosensors has revolutionized various fields, including medical diagnostics, environmental monitoring, and biotechnology ( Escobar et al, 2023 ).…”

Section: Harnessing Peptide-based Biosensors For Mirna Capture and De...mentioning

confidence: 99%

Biosensing circulating MicroRNAs in autoinflammatory skin diseases: Focus on Hidradenitis suppurativa

Moltrasio,

Silva,

Tricarico

et al. 2024

Front. Genet.

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MicroRNAs (miRNAs) play a crucial role in the early diagnosis of autoinflammatory diseases, with Hidradenitis Suppurativa (HS) being a notable example. HS, an autoinflammatory skin disease affecting the pilosebaceous unit, profoundly impacts patients’ quality of life. Its hidden nature, with insidious initial symptoms and patient reluctance to seek medical consultation, often leads to a diagnostic delay of up to 7 years. Recognizing the urgency for early diagnostic tools, recent research identified significant differences in circulating miRNA expression, including miR-24-1-5p, miR-146a-5p, miR26a-5p, miR-206, miR338-3p, and miR-338-5p, between HS patients and healthy controls. These miRNAs serve as potential biomarkers for earlier disease detection. Traditional molecular biology techniques, like reverse transcription quantitative-polymerase chain reaction (RT-qPCR), are employed for their detection using specific primers and probes. Alternatively, short peptides offer a versatile and effective means for capturing miRNAs, providing specificity, ease of synthesis, stability, and multiplexing potential. In this context, we present a computational simulation pipeline designed for crafting peptide sequences that can capture circulating miRNAs in the blood of patients with autoinflammatory skin diseases, including HS. This innovative approach aims to expedite early diagnosis and enhance therapeutic follow-up, addressing the critical need for timely intervention in HS and similar conditions.

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“…However, the degree of control is not only based on the requirements of disease treatment guidelines, but also revolves around the individual characteristics of patients, especially as most T2DM patients are elderly individuals with multiple chronic diseases. Hypoglycemia can even be life-threatening, and since the intestine serves as a storage and digestion organ for food, integrating blood glucose monitoring devices and using device feedback to prevent excessive hypoglycemia is particularly necessary[ 25 , 26 ]. In this sense, the advantages of electronic gastrointestinal stimulation devices become very apparent, as they contain a power source that not only drives the gastrointestinal stimulation device itself but also ensures the energy supply for blood glucose monitoring devices and related chips[ 27 , 28 ].…”

Section: Implanted Electronic Devices In the Intestine For The Treatm...mentioning

confidence: 99%

Gut-targeted therapies for type 2 diabetes mellitus: A review

Xu,

Liu,

et al. 2024

World J Clin Cases

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. The global prevalence of T2DM has reached epidemic proportions, affecting approximately 463 million adults worldwide in 2019. Current treatments for T2DM include lifestyle modifications, oral antidiabetic agents, and insulin therapy. However, these therapies may carry side effects and fail to achieve optimal glycemic control in some patients. Therefore, there is a growing interest in the role of gut microbiota and more gut-targeted therapies in the management of T2DM. The gut microbiota, which refers to the community of microorganisms that inhabit the human gut, has been shown to play a crucial role in the regulation of glucose metabolism and insulin sensitivity. Alterations in gut microbiota composition and diversity have been observed in T2DM patients, with a reduction in beneficial bacteria and an increase in pathogenic bacteria. This dysbiosis may contribute to the pathogenesis of the disease by promoting inflammation and impairing gut barrier function. Several gut-targeted therapies have been developed to modulate the gut microbiota and improve glycemic control in T2DM. One potential approach is the use of probiotics, which are live microorganisms that confer health benefits to the host when administered in adequate amounts. Several randomized controlled trials have demonstrated that certain probiotics, such as Lactobacillus and Bifidobacterium species, can improve glycemic control and insulin sensitivity in T2DM patients. Mechanisms may include the production of short-chain fatty acids, the improvement of gut barrier function, and the reduction of inflammation. Another gut-targeted therapy is fecal microbiota transplantation (FMT), which involves the transfer of fecal material from a healthy donor to a recipient. FMT has been used successfully in the treatment of Clostridioides difficile infection and is now being investigated as a potential therapy for T2DM. A recent randomized controlled trial showed that FMT from lean donors improved glucose metabolism and insulin sensitivity in T2DM patients with obesity. However, FMT carries potential risks, including transmission of infectious agents and alterations in the recipient's gut microbiota that may be undesirable. In addition to probiotics and FMT, other gut-targeted therapies are being investigated for the management of T2DM, such as prebiotics, synbiotics, and postbiotics. Prebiotics are dietary fibers that promote the growth of beneficial gut bacteria, while synbiotics combine probiotics and prebiotics. Postbiotics refer to the metabolic products of probiotics that may have beneficial effects on the host. The NIH SPARC program, or the Stimulating Peripheral Activity to Relieve Conditions, is a research initiative aimed at developing new therapies for a variety of health conditions, including T2DM. The SPARC program focuses on using electrical stimulation to activate peripheral nerves and organs, in order to regulate glucose levels in the body. The goal of this approach is to develop targeted, non-invasive therapies that can help patients better manage their diabetes. One promising area of research within the SPARC program is the use of electrical stimulation to activate the vagus nerve, which plays an important role in regulating glucose metabolism. Studies have shown that vagus nerve stimulation can improve insulin sensitivity and lower blood glucose levels in patients with T2DM. Gut-targeted therapies, such as probiotics and FMT, have shown potential for improving glycemic control and insulin sensitivity in T2DM patients. However, further research is needed to determine the optimal dose, duration, and safety of these therapies.

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Epidermal Wearable Biosensors for Monitoring Biomarkers of Chronic Disease in Sweat

Cited by 16 publications

References 190 publications

Advances in Non-Electrochemical Sensing of Human Sweat Biomarkers: From Sweat Sampling to Signal Reading

Advances in Non-Electrochemical Sensing of Human Sweat Biomarkers: From Sweat Sampling to Signal Reading

Biosensing circulating MicroRNAs in autoinflammatory skin diseases: Focus on Hidradenitis suppurativa

Gut-targeted therapies for type 2 diabetes mellitus: A review

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