Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinomas: Relationship with CT Characteristics and Histologic Subtypes

Lee, Hyun Ju; Kim, Young Tae; Kang, Chang Hyun; Zhao, Binsheng; Tan, Yongqiang; Schwartz, Lawrence H.; Persigehl, Thorsten; Jeon, Yoon Kyung; Chung, Doo Hyun

doi:10.1148/radiol.13112553

Cited by 154 publications

(135 citation statements)

References 34 publications

Supporting

Mentioning

117

Contrasting

Unclassified

Order By: Relevance

“…In addition, previous studies reported that pure or mixed GGO and lepidic dominant histologic subtype could be better predictors for EGFR mutation in lung adenocarcinoma (Hsieh et al, 2005;Yano et al, 2006;Lee et al, 2013). In our results, both lepidic dominant histologic subtype and pure or mixed GGO were related to EGFR mutation in overall patients.…”

Section: Discussionsupporting

confidence: 74%

“…Based on the previous study by Lee et al (2013), the histologic subtype was subdivided into 2 groups: lepidic dominant histologic subtype, including adenocarcinoma in situ, minimally invasive adenocarcinoma, and lepidic predominant invasive adenocarcinoma versus other subtypes. EGFR mutation status was associated with gender, pStage, pT status, lepidic dominant histologic subtype, pure or mixed ground-glass opacity (GGO) on computed tomography and smoking status.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Epidermal Growth Factor Receptor Mutations in Japanese Men with Lung Adenocarcinomas

Tomita

Ayabe²,

Chosa³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

related with never-smoker, women, adenocarcinoma and Asians (Kosaka et al., 2004;Shigematsu et al., 2005;Mitsudomi et al., 2006). Therefore it might demonstrate the role of histology, sex, lifestyle and ethnicity as variables associated with EGFR mutation. To our knowledge, however, there is only one study that focused on EGFR mutation in men and smokers (D'Angelo et al., 2011). Of great interest, they concluded that a large number of EGFR mutations are found in adenocarcinoma tumor specimen from men and people who smoked Masaki Tomita*, Takanori Ayabe, Eiichi Chosa, Katsuya Kawagoe, Kunihide Nakamura cigarettes. In the present study, we focused on the men with adenocarcinoma patients, and we examined the relationship between EGFR mutation and clinical characteristics.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Resultsmentioning

confidence: 99%

Epidermal Growth Factor Receptor Mutations in Japanese Men with Lung Adenocarcinomas

Tomita

Ayabe²,

Chosa³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Furthermore, we found that EGFR mutations were more frequent in patients with lepidic predominant adenocarcinoma than in patients with other types of adenocarcinoma. This can be supported by the results of a prior study which found that EGFR exon 21 mutations were significantly more common in patients with lepidic predominant adenocarcinomas (15). There are limited numbers of reports regarding the association between EGFR mutations and CT imaging features.…”

Section: Thoracic Imaging: Epidermal Growth Factor Receptor Mutation mentioning

confidence: 56%

“…To date, relatively few studies have investigated the relationships between CT imaging features with EGFR mutations (14)(15)(16)(17)(18)(19)(20). Most of these studies have focused on ground-glass opacity (GGO) ratio, and some of the findings are conflicting.…”

Section: Ct Image Interpretationmentioning

confidence: 99%

CT Features Associated with Epidermal Growth Factor Receptor Mutation Status in Patients with Lung Adenocarcinoma

Liu¹,

Kim²,

Qu³

et al. 2016

Radiology

183

178

View full text Add to dashboard Cite

).q RSNA, 2016 Purpose:To retrospectively identify the relationship between epidermal growth factor receptor (EGFR) mutation status, predominant histologic subtype, and computed tomographic (CT) characteristics in surgically resected lung adenocarcinomas in a cohort of Asian patients. materials andMethods:This study was approved by the institutional review board, with waiver of informed consent. Preoperative chest CT findings were retrospectively evaluated in 385 surgically resected lung adenocarcinomas. A total of 30 CT descriptors were assessed. EGFR mutations at exons 18-21 were determined by using the amplification refractory mutation system. Multiple logistic regression analyses were performed to identify independent factors of harboring EGFR mutation status. The final model was selected by using the backward elimination method, and two areas under the receiver operating characteristic curve (ROC) were compared with the nonparametric approach of DeLong, DeLong, and Clarke-Pearson. Results:EGFR mutations were found in 168 (43.6%) of 385 patients. Mutations were found more frequently in (a) female patients (P , .001); (b)those who had never smoked (P , .001); (c)those with lepidic predominant adenocarcinomas (P = .001) or intermediate pathologic grade (P , .001); (e) smaller tumors (P , .001); (f) tumors with spiculation (P = .019), ground-glass opacity (GGO) or mixed GGO (P , .001), air bronchogram (P = .006), bubblelike lucency (P , .001), vascular convergence (P = .024), thickened adjacent bronchovascular bundles (P = .027), or pleural retraction (P , .001); and (g) tumors without pleural attachment (P = .004), a well-defined margin (P = .010), marked heterogeneous enhancement (P = .001), severe peripheral emphysema (P = .002), severe peripheral fibrosis (P = .013), or lymphadenopathy (P = .028). The most important and significantly independent prognostic factors of harboring EGFR-activating mutation for the model with both clinical variables and CT features were those who had never smoked and those with smaller tumors, bubblelike lucency, homogeneous enhancement, or pleural retraction when adjusting for histologic subtype, pathologic grade, or thickened adjacent bronchovascular bundles. ROC curve analysis showed that use of clinical variables combined with CT features (area under the ROC curve = 0.778) was superior to use of clinical variables alone (area under the ROC curve = 0.690). Conclusion:CT imaging features of lung adenocarcinomas in combination with clinical variables can be used to prognosticate EGFR mutation status better than use of clinical variables alone.q RSNA, 2016

show abstract

“…Most reports focused on the presence of any GGO or GGO proportion and some of the findings are conflicting. The definition of GGO proportion differs among studies and the following parameters have been used to calculate the GGO proportion: consolidation/tumor dimension ratio (33,34), GGO/tumor area ratio (35), area ratio of tumor on mediastinal windows to that on lung windows, GGO/tumor volume ratio (6,36,37), and the product of the dimension ratio of the tumor on mediastinal windows to that on lung windows to calculate the tumor shadow disappearance rate (TDR) (37-39).…”

Section: Molecular Pathology and Ct Featuresmentioning

confidence: 99%

Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Gao

Rizzo

et al. 2017

Transl. Lung Cancer Res.

View full text Add to dashboard Cite

Epidermal Growth Factor Receptor Mutation in Lung Adenocarcinomas: Relationship with CT Characteristics and Histologic Subtypes

Cited by 154 publications

References 34 publications

Epidermal Growth Factor Receptor Mutations in Japanese Men with Lung Adenocarcinomas

Epidermal Growth Factor Receptor Mutations in Japanese Men with Lung Adenocarcinomas

CT Features Associated with Epidermal Growth Factor Receptor Mutation Status in Patients with Lung Adenocarcinoma

Pulmonary ground-glass opacity: computed tomography features, histopathology and molecular pathology

Contact Info

Product

Resources

About