Epidermal growth factor prevents gut atrophy and maintains intestinal integrity in rats with acute pancreatitis

Chen, Dong Li

doi:10.3748/wjg.v6.i5.762

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…These findings were not observed with immunoglobulin G or lactoferrin administration. Similarly, growth hormone, insulin‐like growth factor 1 (IGF‐1) recombinant human IGF‐1, glucagon‐like peptide 2, as well as epidermal growth factor are known to promote enterocyte proliferation, 192, 193 reduce ileal mucosal apoptosis, 194 attenuate cytotoxic damage to the intestinal epithelium, 195 decrease intestinal permeability, 196, 197 and diminish bacterial translocation 192, 193, 195–199 in rats. Their effects on bacterial translocation in humans are unknown.…”

Section: Measures To Reduce Bacterial Translocationmentioning

confidence: 99%

Review article: bacterial translocation in the critically ill – evidence and methods of prevention

Gatt

Reddy

MacFie

2006

Aliment Pharmacol Ther

176

120

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Summary Background Delayed sepsis, systemic inflammatory response syndrome (SIRS) and multiorgan failure remain major causes of morbidity and mortality on intensive care units. One factor thought to be important in the aetiology of SIRS is failure of the intestinal barrier resulting in bacterial translocation and subsequent sepsis. Aim This review summarizes the current knowledge about bacterial translocation and methods to prevent it. Methods Relevant studies during 1966–2006 were identified from a literature search. Factors, which detrimentally affect intestinal barrier function, are discussed, as are methods that may attenuate bacterial translocation in the critically ill patient. Results Methodological problems in confirming bacterial translocation have restricted investigations to patients undergoing laparotomy. There are only limited data available relating to specific interventions that might preserve intestinal barrier function or limit bacterial translocation in the intensive care setting. These can be categorized broadly into pre‐epithelial, epithelial and post‐epithelial interventions. Conclusions A better understanding of factors that influence translocation could result in the implementation of interventions which contribute to improved patient outcomes. Glutamine supplementation, targeted nutritional intervention, maintaining splanchnic flow, the judicious use of antibiotics and directed selective gut decontamination regimens hold some promise of limiting bacterial translocation. Further research is required.

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Section: Measures To Reduce Bacterial Translocationmentioning

confidence: 99%

Review article: bacterial translocation in the critically ill – evidence and methods of prevention

Gatt

Reddy

MacFie

2006

Aliment Pharmacol Ther

176

120

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“…In addition, EGF could induce production of TGF-β and they showed cooperative effects [40][41][42] . Reseaches have proven that TGF-β and EGF were crucial for maintaining the integrity and functions of intestine mucosa barrier, and could effectively prevent and ameliorate its injury and dysfunction induced by oxidants, thus contributing to the treatment of intestinal inflammation [42][43][44][45] . Our study showed that ASP significantly increased the levels of EGF and markedly reduced TGF-β in colon tissue of colitis rats, thus accelerating repair of colon lesions, which agreed with investigations of Ye et al [8,9] .…”

Section: Effect Of Asp On Colonic Tgf-β and Egf Expressionsmentioning

confidence: 99%

Protective effect ofangelica sinensispolysaccharide on experimental immunological colon injury in rats

Liu

Dong²,

Wu³

et al. 2003

WJG

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AIM:To study the effect of angelica sinensis polysaccharide (ASP) on immunological colon injury and its mechanisms in rats. METHODS:Immunological colitis model of rats was induced by intracolon enema with 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) and ethanol. The experimental animals were randomly divided into normal control, model control, 5-aminosalicylic acid therapy groups and three doses of ASP therapy groups. The 6 groups were treated intracolonically with normal saline, normal saline, 5-aminosalicylic acid (100 mg·kg -1

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“…Severe acute pancreatitis (SAP), as a common acute abdomen, is characterized by complicated causes, lots of morbidities, difficulties in the treatment, and high mortality [1][2][3][4][5][6][7][8] . The natural course of SAP progresses in two phases.…”

Section: Introductionmentioning

confidence: 99%

Organ failure associated with severe acute pancreatitis

Zhu¹,

Shi²,

Sun³

2003

WJG

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Epidermal growth factor prevents gut atrophy and maintains intestinal integrity in rats with acute pancreatitis

Cited by 13 publications

References 33 publications

Review article: bacterial translocation in the critically ill – evidence and methods of prevention

Review article: bacterial translocation in the critically ill – evidence and methods of prevention

Protective effect ofangelica sinensispolysaccharide on experimental immunological colon injury in rats

Organ failure associated with severe acute pancreatitis

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