Epidermal and Dermal Gamma-Delta T Cells

Tamaki, Kunihiko; Sugaya, Makoto; Tada, Yayoi; Yasaka, Nami; Uehira, Masahiro; Nishimoto, Hirofumi; Nakamura, Koichiro

doi:10.1159/000058831

Cited by 15 publications

(12 citation statements)

References 19 publications

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“…Because very little is known about dermal ␥␦ T cells (30), at this point we can only speculate about their function. However, SCART2 high ␥␦ T cells have an activated/memory phenotype and express high levels of IL-17.…”

Section: Discussionmentioning

confidence: 99%

SCART Scavenger Receptors Identify a Novel Subset of Adult γδ T Cells

Kisielow

Köpf

Karjalainen

2008

The Journal of Immunology

106

114

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Although there has been great progress in the characterization of αβ T cell differentiation, selection, and function, γδ T cells have remained poorly understood. One of the main reasons for this is the lack of γδ T cell-specific surface markers other than the TCR chains themselves. In this study we describe two novel surface receptors, SCART1 and SCART2. SCARTs are related to CD5, CD6, and CD163 scavenger receptors but, unlike them, are found primarily on developing and mature γδ T cells. Characterization of SCART2 positive immature and peripheral γδ T cells suggests that they undergo lineage specification in the thymus and belong to a new IL-17-producing subset with distinct homing capabilities.

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Section: Discussionmentioning

confidence: 99%

SCART Scavenger Receptors Identify a Novel Subset of Adult γδ T Cells

Kisielow

Köpf

Karjalainen

2008

The Journal of Immunology

106

114

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“…The epidermis contains a unique population of γδ T cells, called dendritic epidermal T cells (DETCs) (Havran et al, 1989; Tamaki et al, 2001). DETCs reside within the skin near the interface with the skin and the external environment, indicating their role in barrier function and immunity (Girardi et al, 2002, 2006; Jameson et al, 2002; MacLeod et al, 2013; Sharp et al, 2005).…”

Section: T Cells In Murine Skinmentioning

confidence: 99%

Emerging Skin T-Cell Functions in Response to Environmental Insults

Suwanpradid

Holcomb

MacLeod

2017

Journal of Investigative Dermatology

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Skin is the primary barrier between the body and the outside world, functioning not only as a physical barrier, but also as an immunologic first line of defense. A large number of T cells populate the skin. This review highlights the ability of these cutaneous T cells to regulate skin-specific environmental threats, including microbes, injuries, solar UV radiation, and allergens. Since much of this knowledge has been advanced from murine studies, we focus our review on how the mouse state has informed the human state, emphasizing the key parallels and differences.

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“…In addition, the MCO also possibly causes catalyst poisoning, shortens the life cycle, and reduces the working efficiency of the DMFC. [10,11] Recent studies have shown that the use of hydrogen peroxide as an oxidant is quite helpful to solve the aforementionedproblems. [12][13][14][15] First, due to the excellent kinetics of hydrogen peroxide in the reduction reaction, it is likely to use a non-noble metal catalyst.…”

Section: Introductionmentioning

confidence: 99%

Passive Direct Methanol–Hydrogen Peroxide Fuel Cell with Reduced Graphene Oxide–Supported Prussian Blue as Catalyst

Yuan

et al. 2020

Energy Tech

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Herein, a reduced graphene oxide–supported Prussian Blue (rGO‐PB) composite as the cathode catalyst for a passive direct methanol–hydrogen peroxide fuel cell (DMHPFC) is used. Unlike the conventional passive direct methanol fuel cell (DMFC) with a cathodic catalyst of noble metal platinum (Pt), the new fuel cell uses hydrogen peroxide as the oxidant. This nonnoble metal catalyst has a low cost, high catalytic activity, and high conductivity due to its 3D conductive network. The fuel cell has a theoretical voltage of 1.76 V (higher than 1.21 V related to the traditional DMFC) and can be used in an oxygen‐free environment. Results show that the cell shows good performance with a peak power density of 20.5 mW cm−2 at a higher temperature of 85 °C. The polarization and impedance curves indicate that as the temperature increases, the cell performance improves continuously with the decrease in mass transfer resistance. The discharging tests show a stable cell performance under continuous operation. The cell voltage has an instant response to the change in the current output.

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Epidermal and Dermal Gamma-Delta T Cells

Cited by 15 publications

References 19 publications

SCART Scavenger Receptors Identify a Novel Subset of Adult γδ T Cells

SCART Scavenger Receptors Identify a Novel Subset of Adult γδ T Cells

Emerging Skin T-Cell Functions in Response to Environmental Insults

Passive Direct Methanol–Hydrogen Peroxide Fuel Cell with Reduced Graphene Oxide–Supported Prussian Blue as Catalyst

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