Epidemiology, Risk Factors, and Natural History of Chronic Hepatitis C

Sharma, Nalini; Sherker, Averell H.

doi:10.1007/978-1-59745-565-7_2

Cited by 8 publications

(8 citation statements)

References 157 publications

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“…A mong the estimated 170 million people in the world who have chronic hepatitis C virus (HCV) infection, approximately 60% have the genotype 1 strain of the virus. 1 The treatment of patients infected with HCV genotype 1 is evolving rapidly. [2][3][4][5][6] At the end of 2013, the Food and Drug Administration (FDA) approved two new direct-acting antiviral agents for the treatment of HCV infection: the nucleotide polymerase inhibitor sofosbuvir (Gilead Sciences) and the protease inhibitor simeprevir (Janssen Therapeutics).…”

mentioning

confidence: 99%

Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection

et al. 2014

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confidence: 99%

Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection

et al. 2014

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“…The microdroplets in aerosols should contain a very small proportion of the total number of viruses present in an infected individual (estimates were reported in Artenstein and Miller, 1966;Gerone et al, 1966; see also Clarke et al, 1994 and Chapter 6 for the effect of serial bottlenecks, as assessed in laboratory experiments). Different evolutionary outcomes can be expected when a virus is transmitted through a small or large amount of infected fluids, for example, sharing a syringe versus a transfusion with contaminated blood in the case of HIV-1 or HCV when blood screening had not been implemented (Shepard et al, 2005;Sharma and Sherker, 2009;De Cock et al, 2012). Not only the probability of infection is higher when a susceptible individual is exposed to a large amount of a contaminated fluid, but a massive amount of initial virus facilitates adaptation of the quasispecies to the recipient host.…”

Section: Population Size Limitations and The Effect Of Bottlenecks: Tmentioning

confidence: 99%

Interaction of Virus Populations with Their Hosts

Domingo

2016

Virus as Populations

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“…About 60% of these patients have the genotype 1 strain of Hepatitis C virus. 15 To start the antiviral therapy, it is necessary to find the genotype in order to get better forecast about observed duration of treatment. This also provides the load of virus.…”

Section: Introductionmentioning

confidence: 99%

HCV infection and frequency of distribution.

Aslam

Asif

Zafar

et al. 2019

TPMJ

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Worldwide, an estimated 130-170 million people are infected with Hepatitis C. The geographic distribution of HCV infection is highly variable between and within countries. To start the antiviral therapy, it is necessary to find the genotype in order to get better forecast about observed duration of treatment. This also provides the load of virus. Treatments for patients with chronic HCV infection have recently advanced with newly licensed antivirals, which specifically target HCV. Objectives: To find out the prevalence of HCV in Faisalabad region of Pakistan and to evaluate the frequency distribution of various HCV genotypes among those with HCV infection. Study Design: Descriptive cross sectional. Settings: Blood samples were received from Biotech Lab, Pinum cancer hospital Faisal Laboratory, Alshafa lab Jaranwala, Mehran Lab, Samundari, Rashid Lab, Shahkot and Molecular care, Human Molecular Diagnostic Department of Biochemistry University of Agriculture Faisalabad. Period: May 2016 to April 2017. Material and Methods: The data for this study included a total of 382 anti-HCV positive blood sera samples, collected from different collection centers. Nested reverse transcription (RT) PCR was done for the qualitative detection of HCV. RNA using primers that correspond to the relatively conservative 5'UTR noncoding region of the highly mutable HCV were used. Data was analysed using the descriptive statistics. Results: 233 samples were found to be confirm positive for HCV RNA by qualitative PCR. 98 (42%) were females and 135 (58%) were males. The age-group of 36-45 years bear the largest number of HCV patients (37.08%) and smallest number of patients was in the 56-65 years age-group. A total of 87.55% patients belong were below 45 years of age. The genotype 3a, 135 (77%) was the most prevalent form of all HCV genotypes in Faisalabad. A peripheral area of Faisalabad almost same distribution has been observed. The other strains detected were 2a, 29% 3b 11% were males and 5% were female), and none of the patient was detected with 2b, 4a, 5a and 6a genotype of HCV. Conclusion: This data analysis shows that there is no specific relationship of age-groups or genders in case of prevalence of different HCV Genotypes but female patients were found to have higher frequency of HCV infection.

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Epidemiology, Risk Factors, and Natural History of Chronic Hepatitis C

Cited by 8 publications

References 157 publications

Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection

Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection

Interaction of Virus Populations with Their Hosts

HCV infection and frequency of distribution.

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