Epidemiology, pathology, and treatment of axillary hidradenitis suppurativa

Edlich, Richard F.; Silloway, Kimberly A.; Rodeheaver, George T.; Cooper, Philip H.

doi:10.1016/0736-4679(86)90214-3

Cited by 48 publications

(38 citation statements)

References 23 publications

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“…52,[70][71][72][73] Previous studies have shown conflicting results: one study found HS patients to be more obese (n = 11), 71 another study was unable to reproduce the findings (n = 76). 74,75 It is suggested that while obesity may not be a primary pathogenic factor, it may aggravate preexisting hidradenitis through mechanical irritation, occlusion, and maceration.…”

Section: Obesitymentioning

confidence: 91%

Hidradenitis Suppurativa

Jemec

2002

JCMS

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Section: Obesitymentioning

confidence: 91%

Hidradenitis Suppurativa

Jemec

2002

JCMS

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“…Similarly, dietary interventions, such as avoidance of dairy and high glycemic load foods may improve the clinical course and reduce morbidity rate in HS [57]. This is a very important point because HS is associated with a high body mass index (BMI) [5,58,59], and there is a positive correlation between BMI and disease severity [60]. Beside the linking role of adipokine dysbalance, overweight might influence HS pathogenesis in additional ways.…”

Section: Hs and Metabolic Disordersmentioning

confidence: 97%

Hidradenitis suppurativa/Acne inversa: an endocrine skin disorder?

Karagiannidis

Nikolakis

Sabat

et al. 2016

Rev Endocr Metab Disord

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Hidradenitis suppurativa / acne inversa (HS) is a chronic inflammatory, debilitating skin disorder with a largely unknown etiology. However, many observations such as the typical onset of the disease after puberty, the female predominance, the pre-menstrual flare ups and the improvement during pregnancy suggest a contribution of endocrinological factors to the emergence of the disease. In addition, the reported efficacy of anti-androgen treatment on HS indicates a possible involvement of androgens in the pathogenesis. Furthermore, the common comorbidity with metabolic syndrome points to possible interactions between endocrinological and metabolic alterations in the development of HS. Taking into account the endocrine functions of the human skin, several studies investigated the effects of hormones and the behavior of the pilosebaceous unit in the skin of patients with HS. In this review we describe the current view on the hormonal dysregulation and metabolic syndrome and their role in HS.

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“…4,11,[59][60][61][62] Gram-negative bacteria, such as Escherichia coli, Klebsiella, and Proteus, may be more common in perineal HS. 30,63 Chlamydia trachomatis was demonstrated serologically in 6 of 7 patients with perineal HS but was absent in the pus of examined lesions.…”

mentioning

confidence: 99%

“…3 The disease is insidious, typically developing in otherwise healthy postpubertal males and females. 4 Another lesion typical in HS is the double comedone, a blackhead with multiple apertures that communicate below the skin. 5 These abnormal comedones have been reported on flexural surfaces of children, and may be the precursors of HS lesions.…”

mentioning

confidence: 99%