Epidemiology: Overview and Spatial Clustering

Alexander, Freda E.

doi:10.1007/978-1-4613-0339-8_1

Etiology of Hodgkin’s Disease 1995

DOI: 10.1007/978-1-4613-0339-8_1

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Epidemiology: Overview and Spatial Clustering

Freda E. Alexander

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Cited by 3 publications

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Birth order, sibship size and risk of Hodgkin's disease in children and young adults: A population-based study of 31 million person-years

et al. 1997

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It has been proposed that Hodgkin's disease (HD) may have an infectious origin and that delayed exposure to infection may increase the risk of HD in young adults. This hypothesis is addressed by studying the family structure among children and young adults. The Civil Registration System was used to establish a population‐based cohort consisting of all persons whose mothers were born in Denmark since 1935. Persons who developed HD were identified by linkage with the Danish Cancer Registry. HD incidence rate ratios were estimated based on a log‐linear Poisson regression model. The cohort of 2.1 million persons (aged 0–42 years) was followed for 31.1 million person years, during which period 378 cases of HD occurred. Among children (<15 years, n = 72), the relative risk (RR) of HD tended to increase with increasing sibship size, the relative increase in risk per increase in sibship size (the trend) being 1.28 [95% confidence interval (CI) 1.00–1.63]. The trend for birth order was 1.26 (95% CI 0.92–1.73). Among young adults (≥15 years, n = 306) the risk of HD, on the contrary, tended to decrease with increasing sibship size [trend = 0.91 (95% CI, 0.81–1.03)] and birth order (trend = 0.85 (95% CI, 0.71–1.01). These trends among young adults were significantly different from the corresponding trends among children (p < 0.05). Siblings of cases were at increased risk of HD (RR = 18; 95% CI, 2.2–65, n = 2). Our findings are compatible with the hypothesis that delayed exposure to infection may be a risk factor for HD in young adults, and that early exposure perhaps to another infectious agent may increase the risk of HD in children. Int. J. Cancer 72:977–981, 1997. © 1997 Wiley‐Liss, Inc.

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Birth order, sibship size and risk of Hodgkin's disease in children and young adults: A population-based study of 31 million person-years

et al. 1997

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Epstein-Barr virus (EBV) in Chinese pediatric Hodgkin disease

Zhou

Sandvej

et al. 2001

Cancer

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Incidence and Time Trends in Hodgkin's Disease: from Parts of the United Kingdom (1984-1993)

Cartwright

McNally

Roman

et al. 1998

Leukemia & Lymphoma

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Over 3,000 cases of Hodgkin's Disease diagnosed between 1984-93 were used to examine incidence and time trends. These data are part of the Leukaemia Research Fund's specialist Data Collection Study, which is the only large, population-based data set of its type in Europe. The age specific incidence curves showed different patterns for nodular sclerosis contrasted with all other subtypes combined (non-nodular sclerosis). For nodular sclerosis, there was a female excess for young adults, while for non-nodular sclerosis a gradual rise in incidence with age in both sexes was observed. Incidence varied over time, showing a complex pattern with a decreasing trend in males in all Rye-subtypes and no significant change among females diagnosed with nodular sclerosis. These complex patterns of change are different from those seen in other countries. It is concluded that the results provide clear evidence of the heterogeneity of Hodgkin's disease between the sexes and between subtypes, which should be taken into account in future studies.

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Epidemiology: Overview and Spatial Clustering

Cited by 3 publications

References 47 publications

Birth order, sibship size and risk of Hodgkin's disease in children and young adults: A population-based study of 31 million person-years

Birth order, sibship size and risk of Hodgkin's disease in children and young adults: A population-based study of 31 million person-years

Epstein-Barr virus (EBV) in Chinese pediatric Hodgkin disease

Incidence and Time Trends in Hodgkin's Disease: from Parts of the United Kingdom (1984-1993)

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