Epstein-Barr virus (EBV) in Chinese pediatric Hodgkin disease

Zhou, Xiao‐Yang; Sandvej, Kristian; Li, Pei Juan; Ji, Xiao Long; Yan, Qiaoyuan; Zhang, Xiaoping; Da, Ji Ping; Hamilton‐Dutoit, Stephen

doi:10.1002/1097-0142(20010915)92:6<1621::aid-cncr1488>3.0.co;2-p

Cited by 26 publications

(6 citation statements)

References 66 publications

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“…-Middle East (including Tunisia) [4][5][6][7][8][9][10][11][12]: between 28% of cases in a series from Jordan [12] and 70% of cases from Tunisia [4] were EBV-positive with HL; for Egypt [8], 50% were positive and 67% were of the NS type, which is similar to our findings -East Africa [13][14][15][16]: between 44% and 92% of cases were positive in Kenya -Central and South America [17][18][19][20][21][22][23]: between 31% of cases in Argentina [23] and 84% of cases in Peru [17] were positive -Asia [14,[24][25][26][27][28][29][30]: between 39% of cases in China [30] and 82% of cases in India [24] were positive, and the percentage of positive cases in most other countries was high (50% to 69%). For each country, the first column shows the number (n°) of cases studied whereas the other columns show the percentages of positive cases.…”

Section: Discussionsupporting

confidence: 80%

“…This is in contrast to the low frequencies (35% to 38%) found in the USA [47], the United Arab Emirates [56], and the UK [57]. The age of the children studied was also important, as shown by Zhou et al [30] in China and by Preciado et al [54] in Argentina. In pediatric cases of HL, Chabay et al [58] reported a predominance of the MC subtype (52%) in children in 54 cases of HL from Argentina, in contrast to the NS subtype being the major subtype (83%) in 48 cases of HL from Brazil, and indicated that most of the cases were EBV-positive in both countries.…”

Section: Discussionmentioning

confidence: 76%

“…For children (Table 4), the frequency of EBV-positive cases was very high-ranging from 83% to 100%-in the nine developing countries [15,30,[47][48][49][50][51][52]. This is in contrast to the low frequencies (35% to 38%) found in the USA [47], the United Arab Emirates [56], and the UK [57].…”

Section: Discussionmentioning

confidence: 99%

“…As there is a high incidence of EBV-positive HL in the pediatric age group, the number of pediatric cases included in the various studies may influence the overall EBV positivity rate. The percentage of EBV-associated pediatric cHL (Table 4) ranged from 51% of EBV-associated cHL in one series from the UK [55] to 100% in Peru [17], Honduras [47], and Kenya [15], with the percentages in six other countries ranging from 83-97% [30,[48][49][50][51].…”

Section: Discussionmentioning

confidence: 99%

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Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

et al. 2010

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Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed-Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

et al. 2010

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“…There is good evidence that EBV‐association is particularly common in young children in developing countries. Although it is not known whether this reflects the influence of environmental or genetic factors, both are likely to be involved (Zhou et al , 2001). Thus, the young age of our patients at presentation, and their Middle‐Eastern origin may be relevant to understanding the pathogenesis of their disease.…”

Section: Discussionmentioning

confidence: 99%

Epstein‐Barr virus‐associated familial Hodgkin lymphoma: paediatric onset in three of five siblings

et al. 2005

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SummaryWe report familial Hodgkin lymphoma (FHL) in a family with five children, of which three were human leucocyte antigen (HLA) class I identical. These three siblings were diagnosed with Epstein-Barr virus (EBV)-positive Hodgkin lymphoma within a 6-year period. All three were treated with chemo-and/or radiotherapy and are presently in complete remission. None of the children had evidence of overt immunodeficiency or autoimmune disease. This case contributes to the existing material on FHL and implies a role for both HLA class I antigens and EBV infection of the tumour cell population in the pathogenesis of some cases of FHL.

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Disease patterns in pediatric classical Hodgkin lymphoma: a report from a developing area in Brazil

Barros

Hassan

Niedobitek

2011

Hematological Oncology

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Epidemiological patterns established about 20 years ago, divided classical Hodgkin lymphoma (cHL) in three entities with regard to Epstein-Barr virus (EBV) status and histological subtypes and suggested different epidemiological patterns associated with degree of economic development. Here, we investigated histopathological features and EBV association in 100 consecutive pediatric cHL cases occurring in Rio de Janeiro (Brazil). Age at diagnosis ranged from 3 to 18 years (median 14 years) with 27% of cases ≤10 years. Unexpectedly, we did not observe an early childhood peak with most cases occurring in the >10 years age group. Nodular sclerosis (NS) was the most frequent subtype (69%) and was more frequently observed in the >10 years age group, followed by mixed cellularity (MC, 23%) which was distributed equally between age groups. EBV was identified in 44.8% of cases, without preferential association with age groups (≤10 years vs. >10 years). MC cases were independently associated with EBV infection of tumour cells (p = 0.045) and with a CD4/CD20 ratio <1 in the microenvironment (p = 0.014). Our results suggest that a gradual shift from childhood peak to early adulthood peak may be observed in developing regions. The development of MC subtype may result from early exposure to EBV in the context of an impaired immune system reflected by a CD4/CD20 ratio <1. Conversely, it is possible that NS originates predominantly in the context of a better immune response against EBV and/or tumour antigens expressed in the neoplastic cells.

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Epstein-Barr virus (EBV) in Chinese pediatric Hodgkin disease

Cited by 26 publications

References 66 publications

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

Epstein‐Barr virus‐associated familial Hodgkin lymphoma: paediatric onset in three of five siblings

Disease patterns in pediatric classical Hodgkin lymphoma: a report from a developing area in Brazil

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