Epidemiology of Viral Hepatitis and Liver Diseases in Bangladesh

Abstract

Bangladesh is a South Asian country with a homogeneous population. However, some difference has been demonstrated in the distribution of liver disease in different parts of the country. Hepatitis E remains the principal cause of acute hepatitis in Bangladesh, while chronic liver disease in Bangladesh, including hepatocelullar carcinoma, is predominantly due to hepatitis B virus. Hepatitis B has been extensively studied and characterized in Bangladesh, and some major clinical trials with HBV-related antigens have also been conducted.How to cite this articleAl-Mahtab M. Epidemiology of Viral Hepatitis and Liver Diseases in Bangladesh. Euroasian J Hepato-Gastroenterol 2015;5(1):26-29.

A new therapeutic option for chronic hepatitis B: Reduced dose and shorter duration of a combination therapy with pegylated interferon and entecavir

“…The study presented here is a pilot study and was accomplished in real life situation of Bangladesh, a developing country of Asia with a population of 160 million and harboring about 8 million chronic HBV-infected patients. [5][6][7] The study was undertaken to address multiple variable for designing safer, more efficacious and costeffective therapeutic regimen for treating patients with CHB.…”

“…Studies have shown that HBV is the major cause of all forms of liver diseases in Bangladesh. [5][6][7] To treat chronic HBV infections, currently available therapeutic options include both parenteral and oral agents, which act on various host and viral targets. Randomized-controlled trials (RCTs) have shown the utility of these drugs in reduction of hepatitis B virus (HBV) replication, containment of liver damages and delaying of progression to complications in some patients with CHB.…”

Bangladesh in the road to Eliminate Viral Hepatitis B

“…The Global burden of chronic HBV is approximately 257 million and in 2013 HBV related death was about 686000 1 . Bangladesh has an estimated prevalence of 5.4% HBV infection shown in a study carried out in 2008 2 and 7.5% HBsAg sero-prevalence in another study and more than 10 million patients are chronically infected with HBV and Hepatitis C virus (HCV) 3 . The morbidity and mortality from viral hepatitis is mostly due to acute fulminate hepatitis, cirrhosis and hepato-cellular carcinoma (HCC) the 6 th common cancer and 2 nd important cause of cancer related death globally 3 .…”

“…Bangladesh has an estimated prevalence of 5.4% HBV infection shown in a study carried out in 2008 2 and 7.5% HBsAg sero-prevalence in another study and more than 10 million patients are chronically infected with HBV and Hepatitis C virus (HCV) 3 . The morbidity and mortality from viral hepatitis is mostly due to acute fulminate hepatitis, cirrhosis and hepato-cellular carcinoma (HCC) the 6 th common cancer and 2 nd important cause of cancer related death globally 3 . More than 20,000 deaths occur annually in Bangladesh is due to HCC and different studies showed that 47-61% cause of HCC is due to HBV infection 3 .…”

“…The morbidity and mortality from viral hepatitis is mostly due to acute fulminate hepatitis, cirrhosis and hepato-cellular carcinoma (HCC) the 6 th common cancer and 2 nd important cause of cancer related death globally 3 . More than 20,000 deaths occur annually in Bangladesh is due to HCC and different studies showed that 47-61% cause of HCC is due to HBV infection 3 . The disease burden is increasing in Bangladesh and a data from the department of Virology Dhaka Medical College from 2011 to 2015 showed the rate of HBsAg positivity was always above 20% 4 .…”