Epidemiology of trigeminal neuralgia: an electronic population health data study in Korea

Lee, Cheol-Hyeong; Jang, Ho-Yeon; Won, Hyung‐Sun; Kim, Ja-Sook; Kim, Yeon-Dong

doi:10.3344/kjp.2021.34.3.332

Cited by 18 publications

(16 citation statements)

References 30 publications

(34 reference statements)

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“…In the current study the TN morbidity is greater in women than in men, & it rises with years old. thirteen In line with meta-analysis by Foley et al, (12) who discovered that females outnumber men by 60.5percent, with average years old of onset of TN being 45.4 years. Also, the present study was supported by the systematic review by Zakrzewska et al, 15 who aimed to assess the clinical effectiveness of treatments in studied cases with trigeminal neuralgia & multiple sclerosis.…”

Section: Discussionmentioning

confidence: 70%

“…Surgical intervention for cure of TN is classified into 2 types: Ablation & non-ablation. 12 This potential observational research was showed in department of neurosurgery-Functional unit -Faculty of medicine Al-Azhar University from 2017 to 2021. This research was showed on twenty studied cases who were admitted & operated for Trigeminal neuralgia by different modalities according to patient age and comorbidity.…”

Section: Discussionmentioning

confidence: 97%

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Different modalities of treatment of trigeminal neuralgia

Behiry

ibrahim

El-Azzazy

2022

ijhs

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Background; Trigeminal Neuralgia: It is a syndrome characterised by recurrent sudden & usually unilateral severe brief stabbing. One & more branches of 5th cranial nerve are causing pain. It is painful, brief experience. Pain can occur spontaneously & be triggered by innocuous stimuli like yawning, chewing, light touch, & other transmitted stimuli. & divided by different lengths of pain-free intervals, Aim and objectives; to assess effectiveness of Different Modalities in studied cases with trigeminal neuralgia, Subjects & methods; This research Was showed on group of 20 patients having trigeminal neuralgia manged by different modalities, percutaneous radiofrecuency, microvascular decompression, perephiral neurectomy and nerve block. This study was conducted on patients with variant ages at the time of diagnosis, presenting with trigeminal neuralgia, admitted and managed at neurosurgery- Functional unit -Faculty of medicine Al-Azhar University From 2017 To 2021, Result; The description of of radiologiucal findings by MRI FIESTA. The major finding was no loop compassing (50%) in patients followed by Arterial loop compassing trigeminal nerve (35%). Most of the patients had V1, V2, V3 affected in 70% of the patients, and 20% of the patients had V2, V3 affected, The major surgery done was Radiofrequency (40%) followed by MVD (30%).

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 97%

Different modalities of treatment of trigeminal neuralgia

Behiry

ibrahim

El-Azzazy

2022

ijhs

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“…Frequency in the United States is 2.5 (males) and 5.7 (females) per 100,000 per year [18]. The incidence of TN was 100.21 per 100,000 person-years in Korea and is more common in females and the age group of 51-59 years had the highest prevalence of TN [19]. In contrast to the above frequency data, our study centre has managed only four cases of TN and three were females.…”

Section: Resultsmentioning

confidence: 99%

Some Rare Neurosurgical Pathologies in a Sub-Saharan Tertiary Hospital

Ohaegbulam¹,

Ndubuisi²,

Okwunodulu³

2022

Int J Rare Dis Disord

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Background:In sub-Saharan Africa, several neurosurgical diseases are rare in neurosurgical practice, in contrast to other climes. Poor diagnostic and health facilities are always blamed. More than six decades after the birth of neurosurgery in the region, those deficiencies and workforce have markedly improved in neurosciences. The aim of this study was to identify the uncommon cranial neurosurgical lesions and their frequency in the study centre.Method: Search for rare pathologies was made of prospectively recorded database of 34,670 patients managed at the centre that served a large population of about 47 million black Africans of mostly Igbo ethnicity. Results:The identified rare diseases included cavernoma (4), Moyamoya disease (0), epidermoid cysts (0), Rathke's cyst (1), chordomas (0), colloid cysts (1), pineal region tumours (4), Trigeminal Neuralgia (4), and vestibular schwannoma (5). There is no available explanation for these findings hence the importance of reporting our experience so that other researchers could make contributions. There are no previous reports on this subject from sub-Saharan Africa. Conclusion:The rarity of certain neurosurgical pathologies in the study region is a research challenge. Identification of the cause(s) could be a major scientific breakthrough in epidemiology and prevention of diseases, but this would require international collaboration.

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“…The recurring, episodic, and unpredictable clinical course of TN makes it difficult to determine the exact incidence of the disease. The estimated incidence of TN ranges from 4.3 to 26.8 per 100,000 person-years, with a lifetime prevalence of 0.03% to 0.3% [ 2 , 3 , 4 , 12 , 13 ]. Although the causes are not fully elucidated, the incidence of TN in women is higher than men, and the average age of onset is 53, with the most affected ages between 37 and 67 [ 3 , 12 , 13 , 14 , 15 ].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…The estimated incidence of TN ranges from 4.3 to 26.8 per 100,000 person-years, with a lifetime prevalence of 0.03% to 0.3% [ 2 , 3 , 4 , 12 , 13 ]. Although the causes are not fully elucidated, the incidence of TN in women is higher than men, and the average age of onset is 53, with the most affected ages between 37 and 67 [ 3 , 12 , 13 , 14 , 15 ]. Most cases of TN are sporadic without apparent risk factors.…”

Section: Clinical Featuresmentioning

confidence: 99%

The Molecular Basis and Pathophysiology of Trigeminal Neuralgia

Chen

Perez

et al. 2022

IJMS

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Trigeminal neuralgia (TN) is a complex orofacial pain syndrome characterized by the paroxysmal onset of pain attacks in the trigeminal distribution. The underlying mechanism for this debilitating condition is still not clearly understood. Decades of basic and clinical evidence support the demyelination hypothesis, where demyelination along the trigeminal afferent pathway is a major driver for TN pathogenesis and pathophysiology. Such pathological demyelination can be triggered by physical compression of the trigeminal ganglion or another primary demyelinating disease, such as multiple sclerosis. Further examination of TN patients and animal models has revealed significant molecular changes, channelopathies, and electrophysiological abnormalities in the affected trigeminal nerve. Interestingly, recent electrophysiological recordings and advanced functional neuroimaging data have shed new light on the global structural changes and the altered connectivity in the central pain-related circuits in TN patients. The current article aims to review the latest findings on the pathophysiology of TN and cross-examining them with the current surgical and pharmacologic management for TN patients. Understanding the underlying biology of TN could help scientists and clinicians to identify novel targets and improve treatments for this complex, debilitating disease.

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Epidemiology of trigeminal neuralgia: an electronic population health data study in Korea

Cited by 18 publications

References 30 publications

Different modalities of treatment of trigeminal neuralgia

Different modalities of treatment of trigeminal neuralgia

Some Rare Neurosurgical Pathologies in a Sub-Saharan Tertiary Hospital

The Molecular Basis and Pathophysiology of Trigeminal Neuralgia

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