Epidemiology of transfusion-transmitted infections among multi-transfused patients in seven hospitals in Peru

Laguna-Torres, V. Alberto; Pérez-Bao, J.; Chauca, Gloria; Sovero, Merly; Blichtein, D.; Chunga, Ausberto; Flores, W.; Retamal, A.; Mendoza, S.; Cruz, Marta; Monge, Z.; Lavalle, Mónica Isabel Hanna; Gutiérrez, Johans A. Arica; Málaga, J; Soto, E.; Loayza, Nancy; Bolívar, D.; Reyna, Rodríguez; Mendoza, Carmen de; Ore, Marianela; Gonzalez, Jesus; Suárez, M.; Montano, Silvia M.; Sánchez, José L.; Sateren, Warren B.; Bautista, Christian T.; Olson, James G.; Xueref, Serge

doi:10.1016/s1386-6532(05)80036-8

Cited by 12 publications

(9 citation statements)

References 14 publications

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“…A Peruvian study identified a positive hemodialysis history as a common risk factor associated with HBV, HCV and HTLV-I infection among multi-transfused subjects. Similar to our finding, risk factor for HIV infection was identified as total number of transfusion units received in a multisite study from Peru [2]. The vaccination status against Hepatitis B was low in the current study as against 93.3 % reported in certain studies [14].…”

Section: Discussionsupporting

confidence: 87%

“…viral hepatitis, cytomegalovirus, HIV infection, malaria, parvovirus B-19 etc.) is a serious problem in patients receiving chronic transfusions and undergoing invasive procedures with exposure of circulatory system [1][2][3]. The risk is higher among the subgroup of haemoglobinopathy subjects such as patients suffering from thalassemia and haemophilia [4].…”

Section: Introductionmentioning

confidence: 99%

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A Cross-Sectional Study on Burden of Hepatitis C, Hepatitis B, HIV and Syphilis in Multi-Transfused Thalassemia Major Patients Reporting to a Government Hospital of Central India

Shrivastava

Kumar

Navaid

et al. 2014

Indian J Hematol Blood Transfus

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

A Cross-Sectional Study on Burden of Hepatitis C, Hepatitis B, HIV and Syphilis in Multi-Transfused Thalassemia Major Patients Reporting to a Government Hospital of Central India

Shrivastava

Kumar

Navaid

et al. 2014

Indian J Hematol Blood Transfus

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“…Little is known about HTLV-1/2 infection in blood-transfused patients and in blood donors from Peru 12,17 . Thus, the present study aimed to add information concerning blood donors from Arequipa, a city located in a highlands region of southern Peru whose population has Mestizo (Spanish-Indian) origin.…”

mentioning

confidence: 99%

Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru

Quispe

Feria²,

Santos-Fortuna

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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SuMMarYEpidemiological studies conducted in Peru disclosed HTLV-1 to be prevalent in different ethnic groups, and found HTLV-2 in some Amazonian Indians and in men who have sex with men. No data concerning HTLV-1/2 infection in blood donors from Arequipa, a highlands region in southern Peru, is available. We searched for the presence of HTLV-1 and HTLV-2 antibodies in 2,732 serum samples obtained from blood donors from this geographic area. HTLV-1/2-specific antibodies were detected using an enzyme-linked immunosorbent assay (ELISA) and were confirmed by Western blot (WB). Reactive sera had their blood bags discarded from donation, and the demographic characteristics of the donors were analyzed. Thirty-five sera (1.2%) were HTLV seroreactive by ELISA, and 25 were confirmed HTLV-1-positive by WB. One serum disclosed HTLV-positivity, and the remaining nine serum samples showed indeterminate results by WB; three of which had an HTLV-1 indeterminate Gag profile. The median age of HTLV-positive individuals was 34.6 years; 27 were male and eight were female. All individuals were from southern Peru: 27 from Arequipa, five from Puno, and three from Cuzco. HTLV co-positivity with hepatitis B (five sera) and syphilis (one serum) were detected. Previous transfusion and tattooing were observed in two and one individuals, respectively. No serum was positive for HTLV/HIV co-infection. This study confirmed, for the first time, HTLV-1 infection and the absence of HTLV-2 infection in blood donors from Arequipa, Peru and suggests vertical transmission as the major route of HTLV-1 transmission and acquisition in this geographic region.

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“…In some societies it is still possible to contract HCV infection from the health care system as precautions to guarantee the safety of the blood supply and to ensure adequate sterilisation of re-used medical equipment are not and often cannot be implemented fully. Efforts are being made in these countries to minimise the risk but it is clear that it will be some time before risks are reduced to zero, globally [30][31][32] ( Table 1).…”

Section: Societal Attitudes To Those Most At Risk Of Acquiring Hcvmentioning

confidence: 99%

Controversies in and challenges to our understanding of hepatitis C

Batey¹

2007

WJG

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Discovered in 1989, the hepatitis C virus (HCV) continues to cause significant morbidity and mortality world-wide despite a huge research commitment to defining and understanding the virus and the disease it causes. This paper discusses a number of areas where progress in the management of the HCV have not kept pace with the scientific understanding of the HCV. It is suggested that in the fields of HCV prevention and providing access to treatment, practice falls short of what could be achieved. The role of alcohol in the pathogenesis of HCV liver injury is discussed. Discrimination against those with HCV infection and particularly those in prison settings fails to match good clinical practice. The complicated processes of sharing information between specialty groups is also discussed in an attempt to optimise knowledge dissemination in this field.

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Epidemiology of transfusion-transmitted infections among multi-transfused patients in seven hospitals in Peru

Cited by 12 publications

References 14 publications

A Cross-Sectional Study on Burden of Hepatitis C, Hepatitis B, HIV and Syphilis in Multi-Transfused Thalassemia Major Patients Reporting to a Government Hospital of Central India

A Cross-Sectional Study on Burden of Hepatitis C, Hepatitis B, HIV and Syphilis in Multi-Transfused Thalassemia Major Patients Reporting to a Government Hospital of Central India

Confirming the presence of HTLV-1 infection and the absence of HTLV-2 in blood donors from Arequipa, Peru

Controversies in and challenges to our understanding of hepatitis C

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