A Cross-Sectional Study on Burden of Hepatitis C, Hepatitis B, HIV and Syphilis in Multi-Transfused Thalassemia Major Patients Reporting to a Government Hospital of Central India

Shrivastava, Manisha; Kumar, Sanjeev; Navaid, Seema; Dilip, Chotrani; Rashmi, Dwivedi

doi:10.1007/s12288-014-0462-5

Cited by 15 publications

(12 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the next rates are HBV with four patients (0.68%) and HIV positive with 0%. In some research, such as that of Yaghobi (HCV: 18.86%), Ansari (HCV: 13.1%), Manisha (HCV: 18%), and Gene (HCV: 25%), the prevalence of HCV serology was higher than in our study ( 12 – 14 ). On the other hand, in research performed by Ataie (HCV: 18%), Calderon (HCV: 1.7), Vidga (HCV: 2%), Chakrabarti (HCV: 2%), and Aza (HCV: 7.8%), the spread was lower than in our study ( 15 – 18 ).…”

Section: Discussioncontrasting

confidence: 74%

Evaluation of hepatitis C, hepatitis B, and HIV virus Serology pandemic in thalassemia patients of Shahid Mohammadi Hospital of Bandar Abbas, Iran

Aminianfar¹,

Khani²,

Ghasemzadeh³

2017

Electron physician

View full text Add to dashboard Cite

IntroductionThalassemia patients are prone to the hepatitis C, B, and HIV virus, due to their constant need to receive blood transfusions. Therefore, this research was aimed to determine the epidemic of the aforementioned diseases in thalassemia patients of Shahid Mohammadi Hospital of Bandar Abbas, Iran.MethodsThis cross-sectional study was carried out on thalassemia patients visiting the Thalassemia Hospital of Bandar Abbas from March 21, 2014, to March 22, 2015. Checklists were used to collect the data. HBS-Ag, HCV-Ab, and HIV-Ab tests have been registered for hepatitis B, hepatitis C, and HIV virus, respectively. The data were analyzed using SPSS 19 by Mann-Whitney U test, chi-square test, and independent samples t-test.ResultsAmong 587 records administered into the research, 280 individuals (47.7 %) were men and (52.3 %) were female. The average age of participants was 18.01 ± 9.31 years. The youngest was 1 years old, and the oldest was 46 years old. Four patients under the study (0.7 %) were positive for HBV; 60 (10.2 %) were HCV positive. However, no one in the study was diagnosed HIV positive. In the case of spread, there was no significant difference regarding age and sex in HBV patients. However, in HCV patients, significant differences were found (p=0.044 for gender and p=0.001 for age).ConclusionIn thalassemia, hepatitis C had the highest rate of spread. According to the screening, it was much anticipated that the trend should be falling, but the results show the contrary. Hence, it is recommended that more precise methods such as PCR be used.

show abstract

Section: Discussioncontrasting

confidence: 74%

Evaluation of hepatitis C, hepatitis B, and HIV virus Serology pandemic in thalassemia patients of Shahid Mohammadi Hospital of Bandar Abbas, Iran

Aminianfar¹,

Khani²,

Ghasemzadeh³

2017

Electron physician

View full text Add to dashboard Cite

show abstract

“…15 In India, the prevalence of HCV in thalassemic patients as reported by recent epidemiological studies varies from 18.2% to 25%. [16][17][18][19] Though observational studies demonstrated high SVR rates in real life cohorts of Indian patients with SOF-based treatment, there was no well-established Indian guideline for treatment of HCV with DAA in thalassemic patients. 6,20 Hence, we carried out this study to evaluate efficacy and safety of SOF-based regimen in this special population.…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy of Sofosbuvir and Daclatasvir for Hepatitis C Virus Infection in Patients with β-Thalassemia Major

Mehta

Kabrawala

Nandwani

et al. 2018

Journal of Clinical and Experimental Hepatology

View full text Add to dashboard Cite

show abstract

“…These results corroborate other studies [ 28 , 32 ] that also found no positive cases for HIV in thalassemic patients. Nevertheless, an Indian study found that the seroprevalence of HIV was about 1.5% [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt

Mahmoud

El-Mazary

Khodeary

2016

Advances in Hematology

View full text Add to dashboard Cite

Background. Frequent blood transfusions in thalassemia major children expose them to the risk of transfusion-transmitted infections (TTIs). The aim of this study was to estimate the prevalence of hepatitis C virus (HCV), hepatitis B virus (HBV), human immunodeficiency virus (HIV), and cytomegalovirus (CMV) in thalassemic children attending the Pediatrics Departments of both Sohag and Minia Universities of Upper Egypt, during the period from May 2014 to May 2015. Methods. Serum samples were screened for hepatitis B surface antigen (HBsAg), anti-HCV, anti-CMV, and anti-HIV type 1 and type 2 using the Vitek Immunodiagnostic Assay System. Results. The frequencies of anti-HCV, HBsAg, anti-CMV, and anti-HIV type 1 and type 2 were found to be 37.11%, 4.12%, 4.12%, 0.00%, and 0.00%, respectively. Seropositivity for anti-HCV, HBsAg, and anti-CMV increased with increasing age of the patients, duration of the disease, serum ferritin level (ng/mL), and liver enzymes (U/L), while it was not significantly associated with gender, frequency of blood transfusion, or the status of splenectomy operation (P > 0.05). Conclusion. The frequency of TTIs, especially HCV, is considerably high among Egyptian children with thalassemia major. It is therefore important to implement measures to improve blood transfusion screening, such as polymerase chain reaction, in order to reduce TTIs from blood donor units.

show abstract

A Cross-Sectional Study on Burden of Hepatitis C, Hepatitis B, HIV and Syphilis in Multi-Transfused Thalassemia Major Patients Reporting to a Government Hospital of Central India

Abstract: Need for frequent blood transfusions exposes thalassemia major patients to risk of transfusion-transmitted infections (TTIs

Cited by 15 publications

References 15 publications

Evaluation of hepatitis C, hepatitis B, and HIV virus Serology pandemic in thalassemia patients of Shahid Mohammadi Hospital of Bandar Abbas, Iran

Evaluation of hepatitis C, hepatitis B, and HIV virus Serology pandemic in thalassemia patients of Shahid Mohammadi Hospital of Bandar Abbas, Iran

Safety and Efficacy of Sofosbuvir and Daclatasvir for Hepatitis C Virus Infection in Patients with β-Thalassemia Major

Seroprevalence of Hepatitis C, Hepatitis B, Cytomegalovirus, and Human Immunodeficiency Viruses in Multitransfused Thalassemic Children in Upper Egypt

Contact Info

Product

Resources

About