Epidemiology of the Leishmaniases

Magill, Alan J.

doi:10.1016/s0733-8635(18)30058-5

Cited by 87 publications

(60 citation statements)

References 147 publications

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“…The positive result of the reaction express the effectiveness of cellular immunity in LCL and MCL forms of the disease. Whereas MST is negative in diffuse (anergic) form of ATL 3,5,9,10,12,14 .…”

Section: Discussionmentioning

confidence: 99%

“…Positive reactions in patients with leishmaniasis may reflect the development of host cellular immunity, which indicates protection to potential recurrence of the disease or new infections 4,10,12 .…”

Section: Discussionmentioning

confidence: 99%

“…The aggressiveness of MCL is related to the intensity of MST. However, exacerbated responses (with papule greater than 10 mm in diameter) are not exclusive of MCL 3,5,9,10,12,14 .…”

mentioning

confidence: 96%

“…Exacerbated immunity is the cause of destructive and recurrent mucosal lesions. Non effective immunity leads to anergy with disseminated skin lesions 3,4,10,12 .…”

mentioning

confidence: 99%

“…MST is a delayed hypersensitivity reaction, characterized by type IV immune response, mimicking the granulomatous inflammatory reaction that occurs in leishmaniotic lesions [3][4][5][9][10][11][12]14,15 . All patients with LCL and MCL exhibit positive MST.…”

mentioning

confidence: 99%

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American tegumentary leishmaniasis: langerhans cells in montenegro skin test

Nogueira

Sotto

Cucé

2008

Rev. Inst. Med. trop. S. Paulo

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SuMMarYThis work analyzed the histopathology and epidermal Langerhans cells (LC) of Montenegro skin test (MST) in patients with American tegumentary leishmaniasis (ATL) in order to in situ characterize and compare the immunological reaction of the two major clinical forms of ATL, localized cutaneous leishmaniasis (LCL) and mucocutaneous leishmaniasis (MCL). MST histopathology of both LCL and MCL showed superficial and deep perivascular inflammatory infiltrate composed mainly of lymphocytes and histiocytes. Epidermal LC population was higher in MST biopsies taken from LCL patients when compared to MCL group, at 48 and 72 hours after antigen inoculation. Increased number of epidermal LC displayed in MST biopsies of LCL patients represents specific cellular immunity against parasites. The decrease of LC in MST biopsies of MCL patients does not necessarily indicate a worse specific cellular immunity in this clinical form of leishmaniasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The aggressiveness of MCL is related to the intensity of MST. However, exacerbated responses (with papule greater than 10 mm in diameter) are not exclusive of MCL 3,5,9,10,12,14 .…”

mentioning

confidence: 96%

“…Exacerbated immunity is the cause of destructive and recurrent mucosal lesions. Non effective immunity leads to anergy with disseminated skin lesions 3,4,10,12 .…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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