American tegumentary leishmaniasis: langerhans cells in montenegro skin test

Nogueira, Marcia Ferraz; Sotto, Mírian Nacagami; Cucé, Luiz Carlos

doi:10.1590/s0036-46652008000500007

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…15 It consists of a late hypersensitivity reaction (type IV), which simulates the granulomatous reaction that generally occurs in later phases of leishmaniasis. This explains the positive association between the size of the Montenegro test and the duration of the disease.…”

Section: Discussionmentioning

confidence: 99%

American tegumentary leishmaniasis: correlations among immunological, histopathological and clinical parameters

Martins

Barreto

Lauris

et al. 2014

An. Bras. Dermatol.

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BACKGROUNDAmerican tegumentary leishmaniasis has an annual incidence of 1 to 1.5 million cases. In some cases, the patient's immune response can eliminate the parasite, and the lesion spontaneously resolves. However, when this does not occur, patients develop the disseminated form of the disease. OBJECTIVETo investigate the association between clinical, laboratory and pathological findings in cases of American tegumentary leishmaniasis. METHODSA retrospective study of the medical records of 47 patients with American cutaneous leishmaniasis. Clinical, laboratory and epidemiological data were collected, and semi-quantitative histopathological analyses were performed using the Spearman correlation coefficient (p <0.05). RESULTSMean patient age was 40.5 years. A total of 29.7% individuals were female and 70.2% were male, and 40.4% of the patients were farmers. The ulcerative form was found in 53.2% of patients, of whom 59.6% had lesions in the limbs. The average time to diagnosis was 22.3 months. The following positive correlations were significant: age and duration of the disease, Montenegro reaction, degree of granulomatous transformation and epithelioid cell count; duration of disease, Montenegro reaction and number of lymphocytes; epithelial hyperplasia and edema, hemorrhaging, and epithelial aggression; number of plasmocytes and number of parasites. The main negative correlations found were as follows: age and serology; time and parasite load; epithelial hyperplasia and degree of granulomatous transformation. CONCLUSIONThe long duration of the disease could be explained by the fact that lesions were relatively asymptomatic, and therefore ignored by patients with low literacy levels. Individuals may have simply waited for spontaneous healing, which proved to be dependent on the activation of hypersensitivity mechanisms.

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Section: Discussionmentioning

confidence: 99%

American tegumentary leishmaniasis: correlations among immunological, histopathological and clinical parameters

Martins

Barreto

Lauris

et al. 2014

An. Bras. Dermatol.

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“…Visceral leishmaniasis is characterised by weight loss, fever, cytopaenia and hepatosplenomegaly 6 . The cutaneous form is the most prevalent and is characterised by the presence of ulcers with a well‐defined erythematous border and a central crust that is often haemorrhagic, located in exposed areas of the body and ranging in number from 1 to 10 2,7 . The mucocutaneous form is the most severe and presents clinically a few years following the manifestation of the cutaneous form, affecting the upper aerodigestive tract, with lesions mainly in the oral and nasal mucosa and occasionally in the laryngeal and pharyngeal mucosa 7–9 .…”

Section: Introductionmentioning

confidence: 99%

Leishmaniasis with oral mucosa involvement

et al. 2012

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Introduction:The term leishmaniasis comprises a group of diseases caused by different protozoan species of the genus Leishmania. There are three main clinical forms of leishmaniasis: visceral, cutaneous and mucocutaneous. Exclusive involvement of the mucosa is very rare. Objectives: To present a case of mucocutaneous leishmaniasis in an elderly patient, discuss the clinical presentation, diagnostic process and treatment emphasizing the distinctions from other granulomatous lesions. Case report: A 71-year-old male presenting with a symptomatic lesion on the hard and soft palate, which had developed over a period of 6 months was evaluated. The oral exam revealed a lesion with multiple ulcerated nodules on the hard and soft palate extending to the oropharynx. The diagnostic hypothesis was chronic infectious disease (paracoccidioidomycose, tuberculosis and leishmaniasis) or squamous cell carcinoma. Histopathological, histochemical and immunohistochemical analysis were performed. A chest x-ray revealed a normal pulmonary pattern. The Montenegro skin test was positive. The definitive diagnosis was leishmaniasis with exclusive oral manifestation and the patient was treated with liposomal amphotericin. Conclusions: Localized oral mucosa leishmaniasis is an uncommon event in an immunocompetent patient. Dentists play an important role in the diagnosis of oral leishmaniasis, which has systemic repercussions.

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“…Na forma cutânea, a resposta celular específica é bem modulada, com predominância de citocinas do tipo 1, portanto, nesta forma a imunidade celular está preservada sendo verificada na IDRM (NOGUEIRA, SOTTO, CUCÉ, 2008).…”

Section: Intradermorreação De Montenegro (Idrm)unclassified

“…Isto é o que ocorre na chamada forma mucosa clássica. No entanto, é importante ressaltar que, em alguns casos o surgimento de lesões mucosas não se acompanha de exacerbação da resposta do tipo 1, como em pacientes imunocomprometidos (NOGUEIRA, SOTTO, CUCÉ, 2008).…”

Section: Intradermorreação De Montenegro (Idrm)unclassified

Epidemiologia genética da intradermorreação de Montenegro em uma localidade de Rondônia.

Fioretti¹

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The familial distribution of the response to an antigenic extract of Leishmania was analyzed by applying genetic epidemiology methods. Montenegro skin tests (MST) used to measure the human response to a Leishmania antigen. The present study tested a sample of 313 individuals from the Monte Negro, RO. The objective was to ascertain the relative importance of genetic components in the expression of the studied characteristic. Statistical analyses were performed using SPSS program and complex segregation analysis was made using the unified model of complex segregation analysis (LALOUEL et al., 1983). In order evaluate which effect acts on MST a stepwise multiple regression and correlation between the pairs in the families, was applied. The results of stepwise multiple regression showed that age and gender affect significantly MST. Correlations between of pairs within of families suggested the existence of a significant familial aggregation with a strong genetic component since no significant correlation was found among parents. This familial aggregation was confirmed by complex segregation analysis, which showed that the best model to explain the phenotype transmission in the Monte Negro population was the monogenic recessive one.

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American tegumentary leishmaniasis: langerhans cells in montenegro skin test

Cited by 7 publications

References 12 publications

American tegumentary leishmaniasis: correlations among immunological, histopathological and clinical parameters

American tegumentary leishmaniasis: correlations among immunological, histopathological and clinical parameters

Leishmaniasis with oral mucosa involvement

Epidemiologia genética da intradermorreação de Montenegro em uma localidade de Rondônia.

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