Epidemiology of Suicide by Medication Overdose: A Population–based Study 2011–2019

Azarbakhsh, Habibollah; Moftakhar, Leila; Amiri, Sanaz; Mirahmadizadeh, Alireza

doi:10.1016/j.arcmed.2021.10.006

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…Rahman AU et al, in a survey at Dhaka Medical College Hospital, reported that 86.3% of poisoned patients were ˂30 years of age ( 14 ). The heightened incidence of TCA self-poisoning in the young age group may be attributed to various factors, including academic pressures, a pursuit of independence, medication misuse, social challenges, feelings of isolation, coping with problems without support, high unemployment rates, and financial dependency issues ( 11 ). Our demographic findings highlight that amitriptyline and nortriptyline stand out as the most frequently ingested antidepressant and sedative drugs, often misused for suicidal purposes.…”

Section: Discussionmentioning

confidence: 99%

Electrocardiogram Abnormality in Poisoned Patients with Tricyclic Antidepressant

Javadipour,

Keshtzar,

Parvasi

et al. 2024

MJIRI

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Background A wide variety of electrocardiogram (ECG) changes can manifest with antidepressant drugs, occurring at both therapeutic doses and toxic levels. Notably, ECG abnormalities like wide QRS and QT prolongation may be observed in poisoned patients with tricyclic antidepressants (TCAs), indicating severe conditions that necessitate the implementation of cardiac monitoring systems. This study aimed to investigate ECG Abnormality in poisoned patients with tricyclic antidepressants. Methods This retrospective patient record study was conducted at Razi Hospital in Ahvaz, Iran, from 2006 to 2009. Patient information was extracted from hospital medical records after the established protocol. The chi-square test was employed for initial analysis; subsequently, logistic regression was applied to identify risk factors associated with abnormal ECG findings. We analyzed the data using SPSS (Version 19; IBM) statistical software. P < 0.05 was defined as statistically significant. Results Among the 210 poisoned patients, comprising 88 men (41.9%) and 122 women (58.1%), the majority fell within the age range of 15 to 25 years. In our study, the most commonly ingested drugs by poisoned patients were amitriptyline in 134 patients (63.8%) and nortriptyline in 42 patients (20%). A significant portion of 137 patients (65.2%) exhibited poisoning symptoms within ˂ 6 hours, while 73 patients (34.8%) showed symptoms between 6 and 24 hours. Our findings indicated that the initial symptoms in poisoned patients included a decreased level of consciousness in 168 patients (80%), nausea and vomiting in 20 patients (9.5%), and various other symptoms. Notably, our results revealed ECG changes in 70 patients, with 32 patients (15.2%) showing a QRS widening (> 0.1sec), 5 patients (2.4%) displaying a tall R wave in aVR, 5 patients (2.4%) exhibiting right axis deviation, and other observed changes. Conclusion QRS widening in poisoned patients with tricyclic antidepressants is more frequently observed in symptomatic patients, highlighting the importance of ECG screening in these patients.

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Section: Discussionmentioning

confidence: 99%

Electrocardiogram Abnormality in Poisoned Patients with Tricyclic Antidepressant

Javadipour,

Keshtzar,

Parvasi

et al. 2024

MJIRI

View full text Add to dashboard Cite

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The characteristics of suicide attempters in Chinese patients: Comparison of adolescents, youths, middle-aged and elderly

Chen,

Wang,

Wang

et al. 2024

Journal of Forensic and Legal Medicine

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An Evaluation of Case of Suicide Attempt Application to Emergency Services: A Prospective Study

Akbaba¹,

Atan²,

Tunçez³

et al. 2021

Int j pharm res allied sci

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Suicide is an important public health issue. In this study, we aimed to review suicide attempt cases by applying a 20-item survey to cases where suicide was attempted and a 15-item survey to the individuals in the control group. After obtaining the required approvals, 200 attempted suicide cases were admitted to the ER between 14.12.2015 and 31.07.2016, and a control group consisting of 198 people was included in the study. Data obtained from the surveys were analyzed using the SPSS program. 132 (66%) of the cases that had attempted suicide were female and 68 (34%) male. The most common age group among those who had attempted suicide was the 12-24 age group with 108 cases (54%). The monthly income, education level, and parental education level of those who had attempted suicide were lower than those in the control group. Approximately two-thirds of the cases were not economically independent, approximately 60% were unmarried, 22% had a fragmented or unstable family environment, more than half smoked or drank alcohol, one-quarter had a history of repeated suicide attempts, 27% had been diagnosed with a psychiatric disease, 32% were using psychiatric drugs and 18% (36 people) had a family history of suicide attempts. Family issues were the reasons most commonly adduced for attempted suicide. The most commonly preferred suicide method (86.5% -173 individuals) was medication overdose. Psycho-sociodemographic profile, reasons for the attempted suicide, and risk factors for suicide have been set out in this study.

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Epidemiology of Suicide by Medication Overdose: A Population–based Study 2011–2019

Cited by 3 publications

References 25 publications

Electrocardiogram Abnormality in Poisoned Patients with Tricyclic Antidepressant

Electrocardiogram Abnormality in Poisoned Patients with Tricyclic Antidepressant

The characteristics of suicide attempters in Chinese patients: Comparison of adolescents, youths, middle-aged and elderly

An Evaluation of Case of Suicide Attempt Application to Emergency Services: A Prospective Study

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